Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Stephan W Grill"'
Autor:
Madeline M Keenen, David Brown, Lucy D Brennan, Roman Renger, Harrison Khoo, Christopher R Carlson, Bo Huang, Stephan W Grill, Geeta J Narlikar, Sy Redding
Publikováno v:
eLife, Vol 10 (2021)
In mammals, HP1-mediated heterochromatin forms positionally and mechanically stable genomic domains even though the component HP1 paralogs, HP1α, HP1β, and HP1γ, display rapid on-off dynamics. Here, we investigate whether phase-separation by HP1 p
Externí odkaz:
https://doaj.org/article/1e4bc5d189424ef491218ff0e4ff27e9
Publikováno v:
eLife, Vol 9 (2020)
Proper positioning of cells is essential for many aspects of development. Daughter cell positions can be specified via orienting the cell division axis during cytokinesis. Rotatory actomyosin flows during division have been implied in specifying and
Externí odkaz:
https://doaj.org/article/d951ccc28caf41c3b4b9517f9f98cdd2
Autor:
Kerstin Klinkert, Nicolas Levernier, Peter Gross, Christian Gentili, Lukas von Tobel, Marie Pierron, Coralie Busso, Sarah Herrman, Stephan W Grill, Karsten Kruse, Pierre Gönczy
Publikováno v:
eLife, Vol 8 (2019)
How living systems break symmetry in an organized manner is a fundamental question in biology. In wild-type Caenorhabditis elegans zygotes, symmetry breaking during anterior-posterior axis specification is guided by centrosomes, resulting in anterior
Externí odkaz:
https://doaj.org/article/f761873501a34fd49a8a957932035da4
Autor:
Sundar Ram Naganathan, Sebastian Fürthauer, Josana Rodriguez, Bruno Thomas Fievet, Frank Jülicher, Julie Ahringer, Carlo Vittorio Cannistraci, Stephan W Grill
Publikováno v:
eLife, Vol 7 (2018)
One of the great challenges in biology is to understand the mechanisms by which morphogenetic processes arise from molecular activities. We investigated this problem in the context of actomyosin-based cortical flow in C. elegans zygotes, where large-
Externí odkaz:
https://doaj.org/article/c90f313ebaf244a4938b698e01c0bcd4
Publikováno v:
eLife, Vol 6 (2017)
Externí odkaz:
https://doaj.org/article/7a4ba6d4e6b543149d20da5e6a137b65
Publikováno v:
eLife, Vol 6 (2017)
The actomyosin cell cortex is an active contractile material for driving cell- and tissue morphogenesis. The cortex has a tendency to form a pattern of myosin foci, which is a signature of potentially unstable behavior. How a system that is prone to
Externí odkaz:
https://doaj.org/article/2eb4aae2e765436e95739514ec38eb15
Publikováno v:
eLife, Vol 5 (2016)
Cytokinesis in eukaryotic cells is often accompanied by actomyosin cortical flow. Over 30 years ago, Borisy and White proposed that cortical flow converging upon the cell equator compresses the actomyosin network to mechanically align actin filaments
Externí odkaz:
https://doaj.org/article/773cfc494075402da10ef1e57b54e2e4
Autor:
Sundar Ram Naganathan, Sebastian Fürthauer, Masatoshi Nishikawa, Frank Jülicher, Stephan W Grill
Publikováno v:
eLife, Vol 3 (2014)
Many developmental processes break left–right (LR) symmetry with a consistent handedness. LR asymmetry emerges early in development, and in many species the primary determinant of this asymmetry has been linked to the cytoskeleton. However, the nat
Externí odkaz:
https://doaj.org/article/4206e317d1264e3ba0caa7a928a2adc6
Publikováno v:
New Journal of Physics, Vol 16, Iss 6, p 065009 (2014)
Reaction–diffusion systems have been widely successful in the theoretical description of biological patterning phenomena, giving rise to numerous models based on differing mechanisms, mathematical implementations and parameter choices. However, eve
Externí odkaz:
https://doaj.org/article/4e2fe2c01907477fb9d0a50a28bc84a7
Autor:
Claudio Durán, Sara Ciucci, Alessandra Palladini, Umer Z. Ijaz, Antonio G. Zippo, Francesco Paroni Sterbini, Luca Masucci, Giovanni Cammarota, Gianluca Ianiro, Pirjo Spuul, Michael Schroeder, Stephan W. Grill, Bryony N. Parsons, D. Mark Pritchard, Brunella Posteraro, Maurizio Sanguinetti, Giovanni Gasbarrini, Antonio Gasbarrini, Carlo Vittorio Cannistraci
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Drug use or bacterial infection can cause significant alterations of gastric microbiome. Here, the authors show how advanced pattern recognition by nonlinear machine intelligence can help disclose a bacteria-metabolite network which enlightens mechan
Externí odkaz:
https://doaj.org/article/1a4e3dda819d41df95b04fd64ec82e28