Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Stephan W, Grill"'
Autor:
Claudio Durán, Sara Ciucci, Alessandra Palladini, Umer Z. Ijaz, Antonio G. Zippo, Francesco Paroni Sterbini, Luca Masucci, Giovanni Cammarota, Gianluca Ianiro, Pirjo Spuul, Michael Schroeder, Stephan W. Grill, Bryony N. Parsons, D. Mark Pritchard, Brunella Posteraro, Maurizio Sanguinetti, Giovanni Gasbarrini, Antonio Gasbarrini, Carlo Vittorio Cannistraci
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Drug use or bacterial infection can cause significant alterations of gastric microbiome. Here, the authors show how advanced pattern recognition by nonlinear machine intelligence can help disclose a bacteria-metabolite network which enlightens mechan
Externí odkaz:
https://doaj.org/article/1a4e3dda819d41df95b04fd64ec82e28
Autor:
Akanksha Jain, Vladimir Ulman, Arghyadip Mukherjee, Mangal Prakash, Marina B. Cuenca, Lokesh G. Pimpale, Stefan Münster, Robert Haase, Kristen A. Panfilio, Florian Jug, Stephan W. Grill, Pavel Tomancak, Anastasios Pavlopoulos
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
The mechanics of embryonic tissue spreading over spherical eggs is not fully understood. Here, the authors show that during gastrulation in the red flour beetle, extraembryonic tissue epiboly is facilitated by local actomyosin-mediated fluidization o
Externí odkaz:
https://doaj.org/article/529b9c4a2cf040c58306b6eefc594952
Autor:
Madeline M Keenen, David Brown, Lucy D Brennan, Roman Renger, Harrison Khoo, Christopher R Carlson, Bo Huang, Stephan W Grill, Geeta J Narlikar, Sy Redding
Publikováno v:
eLife, Vol 10 (2021)
In mammals, HP1-mediated heterochromatin forms positionally and mechanically stable genomic domains even though the component HP1 paralogs, HP1α, HP1β, and HP1γ, display rapid on-off dynamics. Here, we investigate whether phase-separation by HP1 p
Externí odkaz:
https://doaj.org/article/1e4bc5d189424ef491218ff0e4ff27e9
Publikováno v:
eLife, Vol 9 (2020)
Proper positioning of cells is essential for many aspects of development. Daughter cell positions can be specified via orienting the cell division axis during cytokinesis. Rotatory actomyosin flows during division have been implied in specifying and
Externí odkaz:
https://doaj.org/article/d951ccc28caf41c3b4b9517f9f98cdd2
Autor:
Marcel Naumann, Arun Pal, Anand Goswami, Xenia Lojewski, Julia Japtok, Anne Vehlow, Maximilian Naujock, René Günther, Mengmeng Jin, Nancy Stanslowsky, Peter Reinhardt, Jared Sterneckert, Marie Frickenhaus, Francisco Pan-Montojo, Erik Storkebaum, Ina Poser, Axel Freischmidt, Jochen H. Weishaupt, Karlheinz Holzmann, Dirk Troost, Albert C. Ludolph, Tobias M. Boeckers, Stefan Liebau, Susanne Petri, Nils Cordes, Anthony A. Hyman, Florian Wegner, Stephan W. Grill, Joachim Weis, Alexander Storch, Andreas Hermann
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Abnormal cytoplasmic aggregates of FUS are a hallmark of some forms of amyotrophic lateral sclerosis (ALS). Here, using neurons derived from patients with FUS-ALS, the authors demonstrate that impairment of PARP-dependent DNA damage signaling is an e
Externí odkaz:
https://doaj.org/article/421d7fe19126448d9734fe819843c747
Autor:
Bipul R. Acharya, Selwin K. Wu, Zi Zhao Lieu, Robert G. Parton, Stephan W. Grill, Alexander D. Bershadsky, Guillermo A. Gomez, Alpha S. Yap
Publikováno v:
Cell Reports, Vol 18, Iss 12, Pp 2854-2867 (2017)
Formins are a diverse class of actin regulators that influence filament dynamics and organization. Several formins have been identified at epithelial adherens junctions, but their functional impact remains incompletely understood. Here, we tested the
Externí odkaz:
https://doaj.org/article/78266f0bc89a48699a31cb4997d97b48
Autor:
Kerstin Klinkert, Nicolas Levernier, Peter Gross, Christian Gentili, Lukas von Tobel, Marie Pierron, Coralie Busso, Sarah Herrman, Stephan W Grill, Karsten Kruse, Pierre Gönczy
Publikováno v:
eLife, Vol 8 (2019)
How living systems break symmetry in an organized manner is a fundamental question in biology. In wild-type Caenorhabditis elegans zygotes, symmetry breaking during anterior-posterior axis specification is guided by centrosomes, resulting in anterior
Externí odkaz:
https://doaj.org/article/f761873501a34fd49a8a957932035da4
Autor:
Anupam Singh, Joan Antoni Soler, Janelle Lauer, Stephan W. Grill, Marcus Jahnel, Marino Zerial, Shashi Thutupalli
Publikováno v:
Nature Physics.
ATPases are a group of enzymes that can cyclically convert the free energy of ATP hydrolysis into mechanical work. GTPases are another class of enzymes that are predominantly associated with signal transduction processes, but their role in mechanotra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e5160872ceafaf1703e327101170487
https://doi.org/10.1038/s41567-023-02009-3
https://doi.org/10.1038/s41567-023-02009-3
Autor:
Jose A. Morin, Sina Wittmann, Sandeep Choubey, Adam Klosin, Stefan Golfier, Anthony A. Hyman, Frank Jülicher, Stephan W. Grill
Publikováno v:
Nature Physics. 18:271-276
Biomolecular condensates are dense assemblies of proteins that form distinct biochemical compartments without being surrounded by a membrane. Some, such as P granules and stress granules, behave as droplets and contain many millions of molecules. Oth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::494916000130a6bb0bba3e5873a5de8b
https://doi.org/10.1038/s41567-021-01462-2
https://doi.org/10.1038/s41567-021-01462-2
Autor:
Sundar Ram Naganathan, Sebastian Fürthauer, Josana Rodriguez, Bruno Thomas Fievet, Frank Jülicher, Julie Ahringer, Carlo Vittorio Cannistraci, Stephan W Grill
Publikováno v:
eLife, Vol 7 (2018)
One of the great challenges in biology is to understand the mechanisms by which morphogenetic processes arise from molecular activities. We investigated this problem in the context of actomyosin-based cortical flow in C. elegans zygotes, where large-
Externí odkaz:
https://doaj.org/article/c90f313ebaf244a4938b698e01c0bcd4