Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Stephan Von Gunten"'
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Significant progress has been made in the elucidation of human antibody repertoires. Furthermore, non-canonical functions of antibodies have been identified that reach beyond classical functions linked to protection from pathogens. Polyclonal immunog
Externí odkaz:
https://doaj.org/article/5d056e09d20947eeb7d7f2d3a920703b
Autor:
Quentin Haas, Nikita Markov, Lukas Muerner, Viviana Rubino, Andrej Benjak, Monika Haubitz, Gabriela M. Baerlocher, Charlotte K. Y. Ng, Christian Münz, Carsten Riether, Adrian F. Ochsenbein, Hans-Uwe Simon, Stephan von Gunten
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
While inhibitory Siglec receptors are known to regulate myeloid cells, less is known about their expression and function in lymphocytes subsets. Here we identified Siglec-7 as a glyco-immune checkpoint expressed on non-exhausted effector memory CD8+
Externí odkaz:
https://doaj.org/article/ee365483dca647a5aef0a91df47591e6
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Aberrant glycosylation is a key feature of malignant transformation. Hypersialylation, the enhanced expression of sialic acid-terminated glycoconjugates on the cell surface, has been linked to immune evasion and metastatic spread, eventually by inter
Externí odkaz:
https://doaj.org/article/257e7df339984d1a8c2bfdd2577ce3e2
Autor:
Eleftheria Girousi, Lukas Muerner, Ludovica Parisi, Silvia Rihs, Stephan von Gunten, Christos Katsaros, Martin Degen
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Variants within the gene encoding for the transcription factor Interferon Regulatory Factor 6 (IRF6) are associated with syndromic and non-syndromic Cleft Lip/Palate (CLP) cases. IRF6 plays a vital role in the regulation of the proliferation/differen
Externí odkaz:
https://doaj.org/article/7c5b3e273a6b4e3d8799c298d51d1e16
Autor:
Stefanie Graeter, Christoph Schneider, Daniëlle Verschoor, Sandro von Däniken, Frank Seibold, Nikhil Yawalkar, Peter Villiger, Jordan D. Dimitrov, David F. Smith, Richard D. Cummings, Hans-Uwe Simon, Tchavdar Vassilev, Stephan von Gunten
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Mild modification of intravenous immunoglobulin (IVIG) has been reported to result in enhanced polyspecificity and leveraged therapeutic effects in animal models of inflammation. Here, we observed that IVIG modification by ferrous ions, heme or low p
Externí odkaz:
https://doaj.org/article/33da449369d0403fa7a3181241cb8b45
Autor:
Stephan von Gunten, Hans-Uwe Simon
Publikováno v:
Cell Death and Disease, Vol 11, Iss 12, Pp 1-2 (2020)
Externí odkaz:
https://doaj.org/article/2486f7d9ecc14ee5b685396e2a933c1a
Autor:
Christoph Schneider, Simone Wicki, Stefanie Graeter, Tankica M. Timcheva, Christian W. Keller, Isaak Quast, Danila Leontyev, Iglika K. Djoumerska-Alexieva, Fabian Käsermann, Stephan M. Jakob, Petya A. Dimitrova, Donald R. Branch, Richard D. Cummings, Jan D. Lünemann, Thomas Kaufmann, Hans-Uwe Simon, Stephan von Gunten
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Intravenous immunoglobulin (IVIG) are purified IgG preparations made from the pooled plasma from thousands of healthy donors and are being tested in preclinical mouse models. Inherent challenges, however, are the pluripotency of IVIG and its
Externí odkaz:
https://doaj.org/article/a3ebe2f0459b4ca9a78b2c3ea77bd2eb
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 13, Iss 2, Pp 314-322 (2017)
Large-scale profiling and monitoring of antibody repertoires is possible through next generation sequencing (NGS), phage display libraries and microarrays. These methods can be combined in a pipeline, which ultimately maps the antibody reactivities o
Externí odkaz:
https://doaj.org/article/ec4eef79969a4372a1aaba5efca1df78
Publikováno v:
Critical Care, Vol 24, Iss 1, Pp 1-2 (2020)
Externí odkaz:
https://doaj.org/article/c6c08a2ce3e0481099a485f84aa813b2
Publikováno v:
Frontiers in Oncology, Vol 8 (2018)
Altered surface glycosylation is a key feature of cancers, including gynecologic malignancies. Hypersialylation, the overexpression of sialic acid, is known to promote tumor progression and to dampen antitumor responses by mechanisms that also involv
Externí odkaz:
https://doaj.org/article/657e74cc36ac4056a1ceb3098d80efe3