Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Stephan Theiss"'
Autor:
Julia Izsak, Henrik Seth, Margarita Iljin, Stephan Theiss, Hans Ågren, Keiko Funa, Ludwig Aigner, Eric Hanse, Sebastian Illes
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Lithium salts are used as mood-balancing medication prescribed to patients suffering from neuropsychiatric disorders, such as bipolar disorder and major depressive disorder. Lithium salts cross the blood-brain barrier and reach the brain par
Externí odkaz:
https://doaj.org/article/dfe9a2628cbc46949c5e6716415a69af
Autor:
Johannes Ptok, Lisa Müller, Philipp Niklas Ostermann, Anastasia Ritchie, Alexander T. Dilthey, Stephan Theiss, Heiner Schaal
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 3069-3076 (2021)
Codon degeneracy of amino acid sequences permits an additional “mRNP code” layer underlying the genetic code that is related to RNA processing. In pre-mRNA splicing, splice site usage is determined by both intrinsic strength and sequence context
Externí odkaz:
https://doaj.org/article/fd1dfa94fcef428e93ddfb76be1828f9
Publikováno v:
Cancer Informatics, Vol 19 (2020)
Reporting of a single nucleotide variant (SNV) follows the Sequence Variant Nomenclature ( http://varnomen.hgvs.org/ ), using an unambiguous numbering scheme specific for coding and noncoding DNA. However, the corresponding sequence neighborhood of a
Externí odkaz:
https://doaj.org/article/4843aaf5e9da451395c5edf5d585828c
Autor:
Julia Izsak, Dzeneta Vizlin-Hodzic, Margarita Iljin, Joakim Strandberg, Janusz Jadasz, Thomas Olsson Bontell, Stephan Theiss, Eric Hanse, Hans Ågren, Keiko Funa, Sebastian Illes
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Persistent neural stem cell (NSC) proliferation is, among others, a hallmark of immaturity in human induced pluripotent stem cell (hiPSC)-based neural models. TGF-β1 is known to regulate NSCs in vivo during embryonic development in rodents. Here we
Externí odkaz:
https://doaj.org/article/66d945539ed34be099807ded70c1bc61
Autor:
Laura Nimtz, Julia Hartmann, Julia Tigges, Stefan Masjosthusmann, Martin Schmuck, Eike Keßel, Stephan Theiss, Karl Köhrer, Patrick Petzsch, James Adjaye, Claudia Wigmann, Dagmar Wieczorek, Barbara Hildebrandt, Farina Bendt, Ulrike Hübenthal, Gabriele Brockerhoff, Ellen Fritsche
Publikováno v:
Stem Cell Research, Vol 45, Iss , Pp - (2020)
Neurotoxicity is mediated by a variety of modes-of-actions leading to disturbance of neuronal function. In order to screen larger numbers of compounds for their neurotoxic potential, in vitro functional neuronal networks (NN) might be helpful tools.
Externí odkaz:
https://doaj.org/article/6ce21a344da041f7ac23989029624edd
Autor:
Maxi Hofrichter, Laura Nimtz, Julia Tigges, Yaschar Kabiri, Friederike Schröter, Brigitte Royer-Pokora, Barbara Hildebrandt, Martin Schmuck, Alexey Epanchintsev, Stephan Theiss, James Adjaye, Jean-Marc Egly, Jean Krutmann, Ellen Fritsche
Publikováno v:
Stem Cell Research, Vol 25, Iss C, Pp 72-82 (2017)
Developmental neurotoxicity (DNT) testing performed in rats is resource-intensive (costs, time, animals) and bears the issue of species extrapolation. Thus, reliable alternative human-based approaches are needed for predicting neurodevelopmental toxi
Externí odkaz:
https://doaj.org/article/98ecb7605fe2410a96b658b6b4f7c456
Autor:
Julia Izsak, Henrik Seth, Mats Andersson, Dzeneta Vizlin-Hodzic, Stephan Theiss, Eric Hanse, Hans Ågren, Keiko Funa, Sebastian Illes
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Reproducibly generating human induced pluripotent stem cell-based functional neuronal circuits, solely obtained from single individuals, poses particular challenges to achieve personalized and patient specific functional neuronal in vitro models. A h
Externí odkaz:
https://doaj.org/article/dcf07ab44f4e414398710e2b811e1c71
Autor:
Lisa Müller, Johannes Ptok, Azlan Nisar, Jennifer Antemann, Ramona Grothmann, Frank Hillebrand, Anna-Lena Brillen, Anastasia Ritchie, Stephan Theiss, Heiner Schaal
Publikováno v:
Nucleic Acids Research. 50:8834-8851
Correct pre-mRNA processing in higher eukaryotes vastly depends on splice site recognition. Beyond conserved 5′ss and 3′ss motifs, splicing regulatory elements (SREs) play a pivotal role in this recognition process. Here, we present in silico des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::377d5fc34b5285c7eb0a2121ef3b9c58
https://doi.org/10.1093/nar/gkac663
https://doi.org/10.1093/nar/gkac663
Autor:
Philipp Niklas Ostermann, Anastasia Ritchie, Johannes Ptok, Stephan Theiss, Lisa Müller, Alexander T Dilthey, Heiner Schaal
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 3069-3076 (2021)
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal
Graphical abstract
Codon degeneracy of amino acid sequences permits an additional “mRNP code” layer underlying the genetic code that is related to RNA processing. In pre-mRNA splicing, splice site usage is determined by both intrinsic streng
Codon degeneracy of amino acid sequences permits an additional “mRNP code” layer underlying the genetic code that is related to RNA processing. In pre-mRNA splicing, splice site usage is determined by both intrinsic streng
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::564060853028c24b8fd36da29b8e3e12
https://doi.org/10.1016/j.csbj.2021.05.033
https://doi.org/10.1016/j.csbj.2021.05.033
Oscillatory slow-wave activity (0.5—100 Hz) emerges during fetal human cortex development reflecting functional consequences of cellular brain ontogeny. Human induced pluripotent stem cell-derived (iPSC) neural in vitro models recapitulate aspects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::635952bb0b57e7bf28d98ac3bce85239
https://doi.org/10.1101/2022.03.14.484311
https://doi.org/10.1101/2022.03.14.484311
