Zobrazeno 1 - 10
of 302
pro vyhledávání: '"Stephan Schilling"'
Autor:
Corinna Höfling, Philippa Donkersloot, Luise Ulrich, Sina Burghardt, Michael Opitz, Stefanie Geissler, Stephan Schilling, Holger Cynis, Dominik Michalski, Steffen Roßner
Publikováno v:
Neurobiology of Disease, Vol 201, Iss , Pp 106671- (2024)
Dipeptidyl peptidase 4 (DPP4; CD26) is involved in the regulation of various metabolic, immunological, and neurobiological processes in healthy individuals. Observations based on epidemiological data indicate that DPP4 inhibition by gliptins, typical
Externí odkaz:
https://doaj.org/article/cfe38e0ff065449d892b89f4cc200a8c
Autor:
Corinna Höfling, Luise Ulrich, Sina Burghardt, Philippa Donkersloot, Michael Opitz, Stefanie Geissler, Stephan Schilling, Holger Cynis, Dominik Michalski, Steffen Roßner
Publikováno v:
Cells, Vol 13, Iss 17, p 1412 (2024)
Glutaminyl cyclase (QC) and its isoenzyme (isoQC) catalyze the formation of N-terminal pyroglutamate (pGlu) from glutamine on a number of neuropeptides, peptide hormones and chemokines. Chemokines of the C-C ligand (CCL) motif family are known to con
Externí odkaz:
https://doaj.org/article/11689dccf9324a1ea32139ce64afeb8b
Autor:
Susan Barendrecht, An Schreurs, Stefanie Geissler, Victor Sabanov, Victoria Ilse, Vera Rieckmann, Rico Eichentopf, Anja Künemund, Benjamin Hietel, Sebastian Wussow, Katrin Hoffmann, Kerstin Körber-Ferl, Ravi Pandey, Gregory W. Carter, Hans-Ulrich Demuth, Max Holzer, Steffen Roßner, Stephan Schilling, Christoph Preuss, Detlef Balschun, Holger Cynis
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-23 (2023)
Abstract Background Hyperphosphorylation and intraneuronal aggregation of the microtubule-associated protein tau is a major pathological hallmark of Alzheimer’s disease (AD) brain. Of special interest is the effect of cerebral amyloid beta depositi
Externí odkaz:
https://doaj.org/article/a9c1be2cbfd647cb8dd039ae107ce4ee
Autor:
Charles Bayly-Jones, Christopher J. Lupton, Claudia Fritz, Hariprasad Venugopal, Daniel Ramsbeck, Michael Wermann, Christian Jäger, Alex de Marco, Stephan Schilling, Dagmar Schlenzig, James C. Whisstock
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Meprin α is a proteolytic regulator of the extracellular matrix that forms enormous oligomeric filaments of unknown purpose. Here, the authors determine by cryo-EM the structural basis of the meprin supercoiled filament and further characterise a sm
Externí odkaz:
https://doaj.org/article/38630ad799064ddaba5722e41c9934b6
Autor:
Kathrin Gnoth, Anke Piechotta, Martin Kleinschmidt, Sandra Konrath, Mathias Schenk, Nadine Taudte, Daniel Ramsbeck, Vera Rieckmann, Stefanie Geissler, Rico Eichentopf, Susan Barendrecht, Maike Hartlage-Rübsamen, Hans-Ulrich Demuth, Steffen Roßner, Holger Cynis, Jens-Ulrich Rahfeld, Stephan Schilling
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-20 (2020)
Abstract Background Amyloid β (Aβ)-directed immunotherapy has shown promising results in preclinical and early clinical Alzheimer’s disease (AD) trials, but successful translation to late clinics has failed so far. Compelling evidence suggests th
Externí odkaz:
https://doaj.org/article/2c961e761ce84b74a60f7925a3750699
Autor:
Thore Hettmann, Stephen D. Gillies, Martin Kleinschmidt, Anke Piechotta, Koki Makioka, Cynthia A. Lemere, Stephan Schilling, Jens-Ulrich Rahfeld, Inge Lues
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract In clinical trials with early Alzheimer’s patients, administration of anti-amyloid antibodies reduced amyloid deposits, suggesting that immunotherapies may be promising disease-modifying interventions against Alzheimer’s disease (AD). Sp
Externí odkaz:
https://doaj.org/article/dab5d0faf6364197a4d53ba697df7975
Autor:
Helen Crehan, Bin Liu, Martin Kleinschmidt, Jens-Ulrich Rahfeld, Kevin X. Le, Barbara J. Caldarone, Jeffrey L. Frost, Thore Hettmann, Birgit Hutter-Paier, Brian O’Nuallain, Mi-Ae Park, Marcelo F. DiCarli, Inge Lues, Stephan Schilling, Cynthia A. Lemere
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-19 (2020)
Abstract Background Pyroglutamate-3 Aβ (pGlu-3 Aβ) is an N-terminally truncated and post-translationally modified Aβ species found in Alzheimer’s disease (AD) brain. Its increased peptide aggregation propensity and toxicity make it an attractive
Externí odkaz:
https://doaj.org/article/a0a62adb0fd742e6bf4a5334e028d25a
Autor:
Praveen Bathini, Tao Sun, Mathias Schenk, Stephan Schilling, Nathan J. McDannold, Cynthia A. Lemere
Publikováno v:
Biomolecules, Vol 12, Iss 7, p 951 (2022)
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by the accumulation of amyloid plaques and hyperphosphorylated tau in the brain. Currently, therapeutic agents targeting amyloid appear promising for AD, however, delivery to th
Externí odkaz:
https://doaj.org/article/b6aecf123a41413a84c77ded4f7c9733
Autor:
Alexandra Bluhm, Sarah Schrempel, Stephan Schilling, Stephan von Hörsten, Anja Schulze, Steffen Roßner, Maike Hartlage-Rübsamen
Publikováno v:
Biomolecules, Vol 12, Iss 7, p 1006 (2022)
The deposition of β-amyloid peptides and of α-synuclein proteins is a neuropathological hallmark in the brains of Alzheimer’s disease (AD) and Parkinson’s disease (PD) subjects, respectively. However, there is accumulative evidence that both pr
Externí odkaz:
https://doaj.org/article/2cf6a5bc4a9446cd8abe2fdaaaa8d090
Publikováno v:
Biomolecules, Vol 12, Iss 5, p 694 (2022)
Neurodegenerative disorders including Parkinson’s disease (PD), Huntington’s disease (HD) and the most frequent, Alzheimer’s disease (AD), represent one of the most urgent medical needs worldwide. Despite a significantly developed understanding
Externí odkaz:
https://doaj.org/article/c73336f6e0cd4c6aa9d38bfaa2e305e0