Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Stephan R. Künzel"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 9, p 4689 (2024)
In atrial fibrillation (AF), multifactorial pathologic atrial alterations are manifested by structural and electrophysiological changes known as atrial remodeling. AF frequently develops in the context of underlying cardiac abnormalities. A critical
Externí odkaz:
https://doaj.org/article/27de68492296412db90e475c31c46728
Autor:
Nivedha Murali Shankar, Paola Ortiz-Montero, Anastasia Kurzyukova, Wiebke Rackwitz, Stephan R. Künzel, Winfried S. Wels, Torsten Tonn, Franziska Knopf, Jiri Eitler
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Natural killer (NK) cells are attractive effectors for adoptive immunotherapy of cancer. Results from first-in-human studies using chimeric antigen receptor (CAR)-engineered primary NK cells and NK-92 cells are encouraging in terms of efficacy and sa
Externí odkaz:
https://doaj.org/article/ffb0dee5b8bf4f79b3022bb7448c7718
Autor:
Stephan R. Künzel, Luise Winter, Maximilian Hoffmann, Theresa A. Kant, Jessica Thiel, Romy Kronstein‐Wiedemann, Erik Klapproth, Kristina Lorenz, Ali El‐Armouche, Susanne Kämmerer
Publikováno v:
Physiological Reports, Vol 11, Iss 17, Pp n/a-n/a (2023)
Abstract Objectives Myocardial infarction (MI) initiates a complex reparative response during which damaged cardiac muscle is replaced by connective tissue. While the initial repair is essential for survival, excessive fibrosis post‐MI is a primary
Externí odkaz:
https://doaj.org/article/d4acd0cfd97d4bfd97efddc275319cda
Autor:
Erik Klapproth, Anke Witt, Pauline Klose, Johanna Wiedemann, Nikitha Vavilthota, Stephan R. Künzel, Susanne Kämmerer, Mario Günscht, David Sprott, Mathias Lesche, Fabian Rost, Andreas Dahl, Erik Rauch, Lars Kattner, Silvio Weber, Peter Mirtschink, Irakli Kopaliani, Kaomei Guan, Kristina Lorenz, Paul Saftig, Michael Wagner, Ali El-Armouche
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Therapeutic interference with the immune response after myocardial infarction holds the potential to close a clinically relevant gap. Here, the authors show that inhibition of a cardiomyocyte-specific ADAM10 / CX3CL1 axis improves post infarction sur
Externí odkaz:
https://doaj.org/article/8d786fd470964db7bb4c1cae17ec3150
Publikováno v:
Heliyon, Vol 8, Iss 9, Pp e10365- (2022)
The combination of the human induced pluripotent stem cell (hiPSC) and organoid technology enables the generation of human 3D culture systems, providing the opportunity to model human tissue-like structures in vitro. This protocol offers the details
Externí odkaz:
https://doaj.org/article/7a2e3177805842fbbd172e70d251bb7f
Autor:
Stephan R. Künzel, Johanna S. E. Rausch, Charlotte Schäffer, Maximilian Hoffmann, Karolina Künzel, Erik Klapproth, Theresa Kant, Natalie Herzog, Jan‐Heiner Küpper, Kristina Lorenz, Svenja Dudek, Ramona Emig, Ursula Ravens, Eva A. Rog‐Zielinska, Rémi Peyronnet, Ali El‐Armouche
Publikováno v:
FEBS Open Bio, Vol 10, Iss 7, Pp 1210-1218 (2020)
Atrial fibrillation (AF) is regularly accompanied by cardiac fibrosis and concomitant heart failure. Due to the heterogeneous nature and complexity of fibrosis, the knowledge about the underlying mechanisms is limited, which prevents effective pharma
Externí odkaz:
https://doaj.org/article/12b9c704df7c46728a2977c9005cd5a5
Autor:
Theresa A. Kant, Manja Newe, Luise Winter, Maximilian Hoffmann, Susanne Kämmerer, Erik Klapproth, Karolina Künzel, Mark P. Kühnel, Lavinia Neubert, Ali El-Armouche, Stephan R. Künzel
Publikováno v:
Cells, Vol 10, Iss 3, p 617 (2021)
Pulmonary fibrosis is the chronic-progressive replacement of healthy lung tissue by extracellular matrix, leading to the destruction of the alveolar architecture and ultimately death. Due to limited pathophysiological knowledge, causal therapies are
Externí odkaz:
https://doaj.org/article/ce7d379484ec469ba064c6024e626d19
Autor:
Eleder Cachorro, Mario Günscht, Mario Schubert, Mirna S. Sadek, Johanna Siegert, Fabian Dutt, Carla Bauermeister, Susann Quickert, Henrik Berning, Felix Nowakowski, Simon Lämmle, Rebecca Firneburg, Xiaojing Luo, Stephan R. Künzel, Erik Klapproth, Peter Mirtschink, Manuel Mayr, Matthias Dewenter, Christiane Vettel, Jordi Heijman, Kristina Lorenz, Kaomei Guan, Ali El-Armouche, Michael Wagner, Susanne Kämmerer
Publikováno v:
Circulation Research, 132(4), 400-414. LIPPINCOTT WILLIAMS & WILKINS
Background: Ventricular arrhythmia and sudden cardiac death are the most common lethal complications after myocardial infarction. Antiarrhythmic pharmacotherapy remains a clinical challenge and novel concepts are highly desired. Here, we focus on the
Publikováno v:
Aktuelle Dermatologie. 48:317-320
ZusammenfassungDie atopische Dermatitis (AD) stellt mit einer Lebenszeitprävalenz von bis zu 20% die häufigste chronisch-entzündliche Hauterkrankung des Menschen dar. Die Leitsymptome sind quälender Pruritus und wiederkehrende ekzematöse Hautlä
Autor:
Eva A. Rog-Zielinska, Elisa Darkow, Susanne Proksch, Matthias Karck, Dorothee Jakob, Peter Kohl, Fabian A. Kari, Constanze Schmidt, Alexander Klesen, Ramona Emig, Tim Guth, Hélène Guizouarn, Stephan R Künzel, Diana Aria, Benoit Allegrini, Rémi Peyronnet, Ana Simon Chica, Friedhelm Beyersdorf, Stéphane N. Hatem, Ursula Ravens
Publikováno v:
Journal of Molecular and Cellular Cardiology
Journal of Molecular and Cellular Cardiology, 2021, 158, pp.49-62. ⟨10.1016/j.yjmcc.2021.05.002⟩
Journal of Molecular and Cellular Cardiology, 2021, 158, pp.49-62. ⟨10.1016/j.yjmcc.2021.05.002⟩
International audience; Aims: Atrial Fibrillation (AF) is an arrhythmia of increasing prevalence in the aging populations of developed countries. One of the important indicators of AF is sustained atrial dilatation, highlighting the importance of mec