Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Stephan R Künzel"'
Autor:
Torsten Tonn, Hans Klingemann, Winfried S Wels, Jiri Eitler, Natalie Wotschel, Laurent Boissel, Michael Bachmann, Wiebke Rackwitz, Venugopal Gudipati, Nivedha Murali Shankar, Anastasia Sidorenkova, Johannes B Huppa, Paola Ortiz-Montero, Corinna Opitz, Stephan R Künzel, Susanne Michen, Achim Temme, Liliana Rodrigues Loureiro, Anja Feldmann
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 2 (2024)
Background The antitumor activity of natural killer (NK) cells can be enhanced by specific targeting with therapeutic antibodies that trigger antibody-dependent cell-mediated cytotoxicity (ADCC) or by genetic engineering to express chimeric antigen r
Externí odkaz:
https://doaj.org/article/635e8a9c7ed146e6934cedabb216012a
Publikováno v:
Heliyon, Vol 8, Iss 9, Pp e10365- (2022)
The combination of the human induced pluripotent stem cell (hiPSC) and organoid technology enables the generation of human 3D culture systems, providing the opportunity to model human tissue-like structures in vitro. This protocol offers the details
Externí odkaz:
https://doaj.org/article/7a2e3177805842fbbd172e70d251bb7f
Autor:
Stephan R. Künzel, Johanna S. E. Rausch, Charlotte Schäffer, Maximilian Hoffmann, Karolina Künzel, Erik Klapproth, Theresa Kant, Natalie Herzog, Jan‐Heiner Küpper, Kristina Lorenz, Svenja Dudek, Ramona Emig, Ursula Ravens, Eva A. Rog‐Zielinska, Rémi Peyronnet, Ali El‐Armouche
Publikováno v:
FEBS Open Bio, Vol 10, Iss 7, Pp 1210-1218 (2020)
Atrial fibrillation (AF) is regularly accompanied by cardiac fibrosis and concomitant heart failure. Due to the heterogeneous nature and complexity of fibrosis, the knowledge about the underlying mechanisms is limited, which prevents effective pharma
Externí odkaz:
https://doaj.org/article/12b9c704df7c46728a2977c9005cd5a5
Autor:
Eleder Cachorro, Mario Günscht, Mario Schubert, Mirna S. Sadek, Johanna Siegert, Fabian Dutt, Carla Bauermeister, Susann Quickert, Henrik Berning, Felix Nowakowski, Simon Lämmle, Rebecca Firneburg, Xiaojing Luo, Stephan R. Künzel, Erik Klapproth, Peter Mirtschink, Manuel Mayr, Matthias Dewenter, Christiane Vettel, Jordi Heijman, Kristina Lorenz, Kaomei Guan, Ali El-Armouche, Michael Wagner, Susanne Kämmerer
Publikováno v:
Circulation Research, 132(4), 400-414. LIPPINCOTT WILLIAMS & WILKINS
Background: Ventricular arrhythmia and sudden cardiac death are the most common lethal complications after myocardial infarction. Antiarrhythmic pharmacotherapy remains a clinical challenge and novel concepts are highly desired. Here, we focus on the
Publikováno v:
Aktuelle Dermatologie. 48:317-320
ZusammenfassungDie atopische Dermatitis (AD) stellt mit einer Lebenszeitprävalenz von bis zu 20% die häufigste chronisch-entzündliche Hauterkrankung des Menschen dar. Die Leitsymptome sind quälender Pruritus und wiederkehrende ekzematöse Hautlä
Autor:
Theresa A. Kant, Manja Newe, Luise Winter, Maximilian Hoffmann, Susanne Kämmerer, Erik Klapproth, Karolina Künzel, Mark P. Kühnel, Lavinia Neubert, Ali El-Armouche, Stephan R. Künzel
Publikováno v:
Cells, Vol 10, Iss 3, p 617 (2021)
Pulmonary fibrosis is the chronic-progressive replacement of healthy lung tissue by extracellular matrix, leading to the destruction of the alveolar architecture and ultimately death. Due to limited pathophysiological knowledge, causal therapies are
Externí odkaz:
https://doaj.org/article/ce7d379484ec469ba064c6024e626d19
Autor:
Erik Klapproth, Anke Witt, Pauline Klose, Johanna Wiedemann, Nikitha Vavilthota, Stephan R. Künzel, Susanne Kämmerer, Mario Günscht, David Sprott, Mathias Lesche, Fabian Rost, Andreas Dahl, Erik Rauch, Lars Kattner, Silvio Weber, Peter Mirtschink, Irakli Kopaliani, Kaomei Guan, Kristina Lorenz, Paul Saftig, Michael Wagner, Ali El-Armouche
Publikováno v:
Nature Communications. 13
After myocardial infarction the innate immune response is pivotal in clearing of tissue debris as well as scar formation, but exaggerated cytokine and chemokine secretion with subsequent leukocyte infiltration also leads to further tissue damage. Her
Autor:
Eva A. Rog-Zielinska, Elisa Darkow, Susanne Proksch, Matthias Karck, Dorothee Jakob, Peter Kohl, Fabian A. Kari, Constanze Schmidt, Alexander Klesen, Ramona Emig, Tim Guth, Hélène Guizouarn, Stephan R Künzel, Diana Aria, Benoit Allegrini, Rémi Peyronnet, Ana Simon Chica, Friedhelm Beyersdorf, Stéphane N. Hatem, Ursula Ravens
Publikováno v:
Journal of Molecular and Cellular Cardiology
Journal of Molecular and Cellular Cardiology, 2021, 158, pp.49-62. ⟨10.1016/j.yjmcc.2021.05.002⟩
Journal of Molecular and Cellular Cardiology, 2021, 158, pp.49-62. ⟨10.1016/j.yjmcc.2021.05.002⟩
International audience; Aims: Atrial Fibrillation (AF) is an arrhythmia of increasing prevalence in the aging populations of developed countries. One of the important indicators of AF is sustained atrial dilatation, highlighting the importance of mec
Autor:
Stephan R Künzel, Maximilian Hoffmann, Claudia Günther, Karolina Künzel, Theresa A Kant, Johanna S E Rausch, Luise Winter, Manja Newe, Erik Klapproth
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology
Skin fibrosis is a complex biological remodeling process occurring in disease like systemic sclerosis, morphea, or eosinophilic fasciitis. Since the knowledge about the underlying pathomechanisms is still incomplete, there is currently no therapy, wh
Publikováno v:
DMW - Deutsche Medizinische Wochenschrift. 146:552-558