Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Stephan P. Persengiev"'
Publikováno v:
Current Gerontology and Geriatrics Research, Vol 2012 (2012)
The molecular instructions that govern gene expression regulation are encoded in the genome and ultimately determine the morphology and functional specifications of the human brain. As a consequence, changes in gene expression levels might be directl
Externí odkaz:
https://doaj.org/article/0bad9bd25b044f4fbf12f51809689afd
Autor:
Nady El Hajj, Thomas Haaf, Carsten P Ade, Julia Böck, Eberhard Schneider, Ronald E. Bontrop, Armin Giese, Ivanela Kondova, Marcus Dittrich, Christian W. Remmele, Tobias Müller, Stephan P. Persengiev, Theo F. J. Kraus
Publikováno v:
Cerebral Cortex (New York, NY)
Epigenetic changes have likely contributed to the large size and enhanced cognitive abilities of the human brain which evolved within the last 2 million years after the human–chimpanzee split. Using reduced representation bisulfite sequencing, we h
Publikováno v:
RNA. 10:12-18
RNA interference is an evolutionarily conserved process in which expression of a specific gene is post-transcriptionally inhibited by a small interfering RNA (siRNA), which recognizes a complementary mRNA and induces its degradation. Currently, RNA i
Publikováno v:
Apoptosis. 8:225-228
Programmed cell death is an integral part of the mechanisms regulating tissue homeostasis. Defects in the apoptotic signaling pathway are often associated with uncontrolled cell proliferation, high mutation rate and malignant transformation. Transcri
Publikováno v:
Genes & Development. 16:1806-1814
The mammalian ATF/CREB family of transcription factors comprises a large group of basic-region leucine zipper (bZIP) proteins whose members mediate diverse transcriptional regulatory functions. Here we report that expression of a specific mouse ATF g
Publikováno v:
Oncogene. 20:5124-5131
E2Fs play a central role in cell proliferation and growth arrest through their ability to regulate genes involved in cell cycle progression, arrest and apoptosis. Recent studies further indicate that this family of transcriptional regulators particip
Insights on the Functional Interactions between miRNAs and Copy Number Variations in the Aging Brain
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 6 (2013)
Frontiers in Molecular Neuroscience
Frontiers in Molecular Neuroscience
MicroRNAs (miRNAs) are regulatory genetic elements that coordinate the expression of thousands of genes and play important roles in brain aging and neurodegeneration. DNA polymorphisms affecting miRNA biogenesis, dosage and gene targeting may represe
Publikováno v:
Molecular and Cellular Biology. 19:6048-6056
E2F transcription factors play a critical role in cell cycle progression through the regulation of genes required for G(1)/S transition. They are also thought to be important for growth arrest; however, their potential role in the cell differentiatio
Publikováno v:
NeuroReport. 8:2091-2095
In mammals, cytosine methylation is important for the regulation of gene expression and chromatin structure. Recently, we have found evidence indicating that the maintained DNA methyltransferase activity is critical for neuronal cell differentiation.
Publikováno v:
Molecular Reproduction and Development. 46:476-481
Trinucleotide repeat sequences have become of great interest due to their association with specific genetic disorders. Here we report the identification of a cDNA containing opa trinucleotide repeats from mouse testis, termed t-OPA. The opa repeat is