Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Stephan N Witt"'
Publikováno v:
PLoS Biology, Vol 19, Iss 7, p e3001331 (2021)
In Parkinson disease (PD), Lewy bodies (LBs) form in the gut or nose and spread into the midbrain. A study in this issue indicates that the spread is due to lysosomes "infected" with prion-like alpha-synuclein (α-syn) transmitting from cell to cell
Externí odkaz:
https://doaj.org/article/3bdc0738b9104ddf9a82d11e5dfb32bb
Autor:
Dhaval Patel, Stephan N Witt
Publikováno v:
Journal of Experimental Neuroscience, Vol 12 (2018)
Retromer is a phylogenetically conserved, multisubunit coat complex that controls endosomal protein trafficking and sorting. Mutations in the retromer gene VPS35 cause late-onset Parkinson disease, suggesting that trafficking defects cause neurodegen
Externí odkaz:
https://doaj.org/article/0d53e0f9f5364fa5b7300cdb0dd17946
Autor:
Shaoxiao Wang, Siyuan Zhang, Chuan Xu, Addie Barron, Floyd Galiano, Dhaval Patel, Yong Joo Lee, Guy A Caldwell, Kim A Caldwell, Stephan N Witt
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164465 (2016)
We have been investigating the role that phosphatidylethanolamine (PE) and phosphatidylcholine (PC) content plays in modulating the solubility of the Parkinson's disease protein alpha-synuclein (α-syn) using Saccharomyces cerevisiae and Caenorhabdit
Externí odkaz:
https://doaj.org/article/b5d246b195c940e9a80f7ff71ec7f5e3
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64337 (2013)
The Ras-adenylyl cyclase-protein kinase A nutrient-sensing pathway controls metabolism, proliferation and resistance to stress in Saccharomyces cerevisiae. The genetic disruption of this pathway increases resistance to a variety of stresses. We show
Externí odkaz:
https://doaj.org/article/25ea2728b2824d13824e67776113c098
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e15946 (2011)
We identified three S. cerevisiae lipid elongase null mutants (elo1Δ, elo2Δ, and elo3Δ) that enhance the toxicity of alpha-synuclein (α-syn). These elongases function in the endoplasmic reticulum (ER) to catalyze the elongation of medium chain fa
Externí odkaz:
https://doaj.org/article/c0f6bc6bab2740c199a2ea554d54c947
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract The Parkinson’s disease (PD) associated protein, alpha-synuclein (α-syn/SNCA), is highly expressed in aggressive melanomas. The goal of this study was to reveal possible mechanism(s) of α-syn involvement in melanoma pathogenesis. Herein,
Externí odkaz:
https://doaj.org/article/af35de03323d4cfe9615f8945c2de986
Autor:
Terry C. Lairmore, Jehan Abdulsattar, Arrigo De Benedetti, Runhua Shi, Shile Huang, Md Imtiaz Khalil, Stephan N. Witt
Publikováno v:
BMC Research Notes, Vol 16, Iss 1, Pp 1-7 (2023)
Abstract Background MEN1, which codes for the protein menin, is a tumor suppressor in neuroendocrine tissue. In cholangiocarcinoma (CCA) cell lines the overexpression of menin decreased proliferation, angiogenesis, migration, and invasion in vitro an
Externí odkaz:
https://doaj.org/article/274d4b51de0545169d190e224abda9a9
Publikováno v:
Biochem Biophys Res Commun
By an unknown mechanism, alpha-synuclein (α-syn) inhibits autophagy in yeast and human cells. Herein, using the yeast Saccharomyces cerevisiae, we tested the hypothesis that α-syn disrupts autophagy by inhibiting the required association of sorting
Autor:
Patricia P Peterson, Stephan N. Witt, Lucy C. Robinson, Zhengchang Liu, Santhanasabapathy Rajasekaran
Publikováno v:
Hum Mol Genet
We tested the ability of alpha-synuclein (α-syn) to inhibit Snx3-retromer-mediated retrograde trafficking of Kex2 and Ste13 between late endosomes and the trans-Golgi network (TGN) using a Saccharomyces cerevisiae model of Parkinson’s disease. Kex
Autor:
Nirjhar M. Aloy, Michael W. Graner, Christina Coughlan, Sergey V. Slepenkov, Sahar Shekoohi, Stephan N. Witt
Publikováno v:
Cancer Research. 82:1575-1575
The purpose of this study is to understand the role of α-synuclein in the regulation of the trafficking and release of modulators of metastasis in melanoma. Metastasis causes melanoma-induced death and 5-year survival rates, subsequent to metastasis