Zobrazeno 1 - 10
of 204
pro vyhledávání: '"Stephan M, Huber"'
Autor:
Nicolai Stransky, Katrin Ganser, Leticia Quintanilla-Martinez, Irene Gonzalez-Menendez, Ulrike Naumann, Franziska Eckert, Pierre Koch, Stephan M. Huber, Peter Ruth
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract The intermediate-conductance calcium-activated potassium channel KCa3.1 has been proposed to be a new potential target for glioblastoma treatment. This study analyzed the effect of combined irradiation and KCa3.1-targeting with TRAM-34 in th
Externí odkaz:
https://doaj.org/article/0dbdaeb29d4f406cafec13f476947a99
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Therapies with weak, non-ionizing electromagnetic fields comprise FDA-approved treatments such as Tumor Treating Fields (TTFields) that are used for adjuvant therapy of glioblastoma. In vitro data and animal models suggest a variety of biological TTF
Externí odkaz:
https://doaj.org/article/41a9380da0744cc6925c1195dcb9ceba
Autor:
Nicolai Stransky, Stephan M. Huber
Publikováno v:
Biomolecules, Vol 12, Iss 4, p 573 (2022)
In the study of Chen et al. [...]
Externí odkaz:
https://doaj.org/article/13d2b5a84bb446c2aee9edccc9bb8b7f
Autor:
Daniela Palme, Milan Misovic, Katrin Ganser, Lukas Klumpp, Helmut R. Salih, Daniel Zips, Stephan M. Huber
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Many tumor cells express highly elevated activities of voltage-gated K+ channels in the plasma membrane which are indispensable for tumor growth. To test for K+ channel function during DNA damage response, we subjected human chronic myeloid leukemia
Externí odkaz:
https://doaj.org/article/6fdf212c7870429382be3f276b374aff
Autor:
Lisa Zirjacks, Nicolai Stransky, Lukas Klumpp, Lukas Prause, Franziska Eckert, Daniel Zips, Sabine Schleicher, Rupert Handgretinger, Stephan M. Huber, Katrin Ganser
Publikováno v:
Biomolecules, Vol 11, Iss 11, p 1561 (2021)
Mesenchymal glioblastoma stem cells (GSCs), a subpopulation in glioblastoma that are responsible for therapy resistance and tumor spreading in the brain, reportedly upregulate aldehyde dehydrogenase isoform-1A3 (ALDH1A3) which can be inhibited by dis
Externí odkaz:
https://doaj.org/article/b762c8c38f64496dbf25ca231191fa66
Autor:
Friederike A. Steudel, Corinna J. Mohr, Benjamin Stegen, Hoang Y. Nguyen, Andrea Barnert, Marc Steinle, Sandra Beer‐Hammer, Pierre Koch, Wing‐Yee Lo, Werner Schroth, Reiner Hoppe, Hiltrud Brauch, Peter Ruth, Stephan M. Huber, Robert Lukowski
Publikováno v:
Molecular Oncology, Vol 11, Iss 9, Pp 1172-1188 (2017)
Oncogenic signalling via Ca2+‐activated K+ channels of intermediate conductance (SK4, also known as KCa3.1 or IK) has been implicated in different cancer entities including breast cancer. Yet, the role of endogenous SK4 channels for tumorigenesis i
Externí odkaz:
https://doaj.org/article/d69d7c0b9d5d4580b6bcaccda5f3a017
Autor:
Franziska Eckert, Kerstin Zwirner, Simon Boeke, Daniela Thorwarth, Daniel Zips, Stephan M. Huber
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
In order to compensate for the increased oxygen consumption in growing tumors, tumors need angiogenesis and vasculogenesis to increase the supply. Insufficiency in this process or in the microcirculation leads to hypoxic tumor areas with a significan
Externí odkaz:
https://doaj.org/article/b34f07799cbb49cb96ba5a5c270bc9fd
Autor:
Sophia A. Hogh-Binder, Diana Klein, Frederik Wolfsperger, Stephan M. Huber, Jörg Hennenlotter, Arnulf Stenzl, Justine Rudner
Publikováno v:
Cancers; Volume 15; Issue 9; Pages: 2496
Background: Radiotherapy constitutes an important therapeutic option for prostate cancer. However, prostate cancer cells often acquire resistance during cancer progression, limiting the cytotoxic effects of radiotherapy. Among factors regulating sens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f01e234bf4f79fc3f49fed20f12974a
Autor:
Tatjana Vatter, Lukas Klumpp, Katrin Ganser, Nicolai Stransky, Daniel Zips, Franziska Eckert, Stephan M. Huber
Publikováno v:
Biomolecules, Vol 10, Iss 6, p 917 (2020)
Methadone, which is used as maintenance medication for outpatient treatment of opioid dependence or as an analgesic drug, has been suggested by preclinical in vitro and mouse studies to induce cell death and sensitivity to chemo- or radiotherapy in l
Externí odkaz:
https://doaj.org/article/343dff73985942f18d4e32d15d1c5142
Autor:
Franziska Eckert, Karin Schilbach, Lukas Klumpp, Lilia Bardoscia, Efe Cumhur Sezgin, Matthias Schwab, Daniel Zips, Stephan M. Huber
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Cancer immunotherapy has been established as standard of care in different tumor entities. After the first reports on synergistic effects with radiotherapy and the induction of abscopal effects—tumor shrinkage outside the irradiated volume attribut
Externí odkaz:
https://doaj.org/article/b9be97b9a760414ba991e81dadfab52c