Zobrazeno 1 - 10 of 43 pro vyhledávání: '"Stephan Lortz"'
1
Akademický článek
HSPB1 Is Essential for Inducing Resistance to Proteotoxic Stress in Beta-Cells
Autor: Vinícius M. Gomes, Rosangela A. M. Wailemann, Gabriel S. Arini, Talita C. Oliveira, Daria R. Q. Almeida, Ancély F. dos Santos, Letícia F. Terra, Stephan Lortz, Leticia Labriola
Publikováno v: Cells, Vol 10, Iss 9, p 2178 (2021)
During type 1 diabetes mellitus (T1DM) development, beta-cells undergo intense endoplasmic reticulum (ER) stress that could result in apoptosis through the failure of adaptation to the unfolded protein response (UPR). Islet transplantation is conside
Externí odkaz: https://doaj.org/article/d69592ff84df4fdfb9374c470547755e
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2
Akademický článek
TriPer, an optical probe tuned to the endoplasmic reticulum tracks changes in luminal H2O2
Autor: Eduardo Pinho Melo, Carlos Lopes, Peter Gollwitzer, Stephan Lortz, Sigurd Lenzen, Ilir Mehmeti, Clemens F. Kaminski, David Ron, Edward Avezov
Publikováno v: BMC Biology, Vol 15, Iss 1, Pp 1-15 (2017)
Abstract Background The fate of hydrogen peroxide (H2O2) in the endoplasmic reticulum (ER) has been inferred indirectly from the activity of ER-localized thiol oxidases and peroxiredoxins, in vitro, and the consequences of their genetic manipulation,
Externí odkaz: https://doaj.org/article/922d71cfe9cb41b1949d315efd61a13f
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4
Luminal H
Autor: Sarah, Sharifi, Maren, Böger, Stephan, Lortz, Ilir, Mehmeti
Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 37(1)
The endoplasmic reticulum (ER) lumen is not only the major site for the assembly and folding of newly synthesized proteins but also the main intracellular Ca
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5ddfcc4bad89c8d2d2f6c385a3313160
https://pubmed.ncbi.nlm.nih.gov/36468845
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5
HSPB1 Is Essential for Inducing Resistance to Proteotoxic Stress in Beta-Cells
Autor: Daria Raquel Queiroz de Almeida, Stephan Lortz, Ancély Ferreira dos Santos, Gabriel S. Arini, Leticia Labriola, Talita C. Oliveira, Rosangela A. M. Wailemann, Vinícius M. Gomes, Letícia Ferreira Terra
Publikováno v: Cells; Volume 10; Issue 9; Pages: 2178
Cells, Vol 10, Iss 2178, p 2178 (2021)
Cells
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
During type 1 diabetes mellitus (T1DM) development, beta-cells undergo intense endoplasmic reticulum (ER) stress that could result in apoptosis through the failure of adaptation to the unfolded protein response (UPR). Islet transplantation is conside
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::846961cde56f7dd3c469e52dd635f550
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6
ER-resident antioxidative GPx7 and GPx8 enzyme isoforms protect insulin-secreting INS-1E β-cells against lipotoxicity by improving the ER antioxidative capacity
Autor: Anne Jörns, Stephan Lortz, Sigurd Lenzen, Edward Avezov, Ilir Mehmeti
Publikováno v: Free Radical Biology and Medicine. 112:121-130
Increased circulating levels of saturated fatty acids (FFAs) and glucose are considered to be major mediators of β-cell dysfunction and death in T2DM. Although it has been proposed that endoplasmic reticulum (ER) and oxidative stress play a crucial
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfc19bb332da6945478e0989a3560fd5
https://doi.org/10.1016/j.freeradbiomed.2017.07.021
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8
Hydrogen peroxide permeability of cellular membranes in insulin-producing cells
Autor: Christina Schaal, Matthias Elsner, Anna Laporte, Sigurd Lenzen, Stephan Lortz
Publikováno v: Biochimica et biophysica acta. Biomembranes. 1862(2)
Hydrogen peroxide (H2O2) plays a central role in redox signalling and in oxidative stress-mediated cell death. It is generated through multiple mechanisms at various intracellular sites. Due to its chemical stability it can reach distant sites of act
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3b7eb5fc36b5334e1847901f9a85ae3
https://pubmed.ncbi.nlm.nih.gov/31672544
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9
Heat shock protein B1 is a key mediator of prolactin-induced beta-cell cytoprotection against oxidative stress
Autor: Flavia Carla Meotti, Giuseppe Palmisano, Walter R. Terra, Letícia Ferreira Terra, Rosangela A. M. Wailemann, Leticia Labriola, Anna Laporte, Vinícius M. Gomes, Stephan Lortz, Railmara Pereira da Silva, Ancély Ferreira dos Santos
Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Maintaining islet cell viability in vitro, although challenging, appears to be a strategy for improving the outcome of pancreatic islet transplantation. We have shown that prolactin (PRL) leads to beta-cell cytoprotection against apoptosis, an effect
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d40520d2864446003ee600a72909091
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10
Impact of scavenging hydrogen peroxide in the endoplasmic reticulum for β cell function
Autor: Sigurd Lenzen, Ilir Mehmeti, Stephan Lortz
Publikováno v: Journal of Molecular Endocrinology. 55:21-29
Oxidative folding of nascent proteins in the endoplasmic reticulum (ER), catalysed by one or more members of the protein disulfide isomerase family and the sulfhydryl oxidase ER oxidoreductin 1 (ERO1), is accompanied by generation of hydrogen peroxid
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aad3caa4f56431b5a0b414f4615de78
https://doi.org/10.1530/jme-15-0132
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