Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Stephan Löser"'
Autor:
Katie A. Hildersley, Tom N. McNeilly, Victoria Gillan, Thomas D. Otto, Stephan Löser, François Gerbe, Philippe Jay, Rick M. Maizels, Eileen Devaney, Collette Britton
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Helminth parasite infections of humans and livestock are a global health and economic problem. Resistance of helminths to current drug treatment is an increasing problem and alternative control approaches, including vaccines, are needed. Effective va
Externí odkaz:
https://doaj.org/article/3d47635cf36f42a0a19214acb01c4e0c
Autor:
Kara J. Filbey, Fumi Varyani, Yvonne Harcus, James P. Hewitson, Danielle J. Smyth, Henry J. McSorley, Alasdair Ivens, Susanne Nylén, Martin Rottenberg, Stephan Löser, Rick M. Maizels
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Immunity to intestinal helminths is known to require both innate and adaptive components of the immune system activated along the Type 2 IL-4R/STAT6-dependent pathway. We have found that macrophage migration inhibitory factor (MIF) is essential for t
Externí odkaz:
https://doaj.org/article/4ef2bdd6330249d7a3a47b2de062d4dc
Autor:
Caroline Chauché, Orhan Rasid, Anne‐Marie Donachie, Caitlin M. McManus, Stephan Löser, Tiffany Campion, Josh Richards, Danielle J. Smyth, Henry J. McSorley, Rick M. Maizels
Publikováno v:
Immunology. 167:197-211
Type 2-high asthma is a chronic inflammatory disease of the airways which is increasingly prevalent in countries where helminth parasite infections are rare, and characterized by T helper 2 (Th2)-dependent accumulation of eosinophils in the lungs. Re
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
ILCs burst onto the immunological scene with their involvement in bacterial and helminth infections. As their influence has emerged, it has become clear that they play a fundamental role in regulating barrier tissue homeostasis and the immune respons
Externí odkaz:
https://doaj.org/article/d9d4839ec76245bb95e19309e65893ed
Autor:
Katherine A Smith, Stephan Löser, Fumi Varyani, Yvonne Harcus, Henry J McSorley, Andrew NJ McKenzie, Rick M Maizels
Publikováno v:
eLife, Vol 7 (2018)
Interleukin 25 (IL-25) is a major 'alarmin' cytokine, capable of initiating and amplifying the type immune response to helminth parasites. However, its role in the later effector phase of clearing chronic infection remains unclear. The helminth Helig
Externí odkaz:
https://doaj.org/article/ae6d715a2a584973863243306f5a8c0b
Autor:
Marta Campillo Poveda, Claire Drurey, Menno J. Oudhoff, François Gerbe, Håvard T. Lindholm, Stephan Löser, Rory Doolan, Gillian Coakley, Rick M. Maizels, Nicola L. Harris, Philippe Jay
Publikováno v:
The Journal of Experimental Medicine
The intestinal helminth Heligmosomoides polygyrus suppresses development of epithelial tuft cells, which are essential for the type 2 immune response, through secreted factors that block tuft cells both in intestinal organoids and when administered i
Autor:
Anton Volkov, Stefanie Hagner, Stephan Löser, Safa Alnahas, Hartmann Raifer, Anne Hellhund, Holger Garn, Ulrich Steinhoff
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60565 (2013)
The immunoproteasome subunit β5i has been shown to play an important role in Th1/Th17 driven models of colitis and arthritis. However, the function of β5i in Th2 dependent diseases remains enigmatic. To study the role of β5i in Th2-driven patholog
Externí odkaz:
https://doaj.org/article/db2e102d3e084542b697adbc12f4c857
Autor:
Rick M. Maizels, Stephan Löser
Publikováno v:
Current Biology. 28:R33-R36
Type 2 immunity at mucosal surfaces is thought to be initiated by type 2 innate lymphoid cells. New studies report that these cells are themselves activated by the neuropeptide neuromedin U, produced by cholinergic neurons in the gut and in airways.
Publikováno v:
Frontiers in Immunology
ILCs burst onto the immunological scene with their involvement in bacterial and helminth infections. As their influence has emerged, it has become clear that they play a fundamental role in regulating barrier tissue homeostasis and the immune respons