Zobrazeno 1 - 10
of 437
pro vyhledávání: '"Stephan Krähenbühl"'
Autor:
Isabella Sudano, Stephan Krähenbühl, François Mach, Anne Anstett, Nafeesa Dhalwani, Ian Bridges, Mahendra Sibartie, Kausik K. Ray
Publikováno v:
Therapeutic Advances in Cardiovascular Disease, Vol 18 (2024)
Aims: The HEYMANS study observed patients receiving evolocumab as part of routine clinical hyperlipidemia management. It was designed to capture data on clinical parameters relevant to health authorities and physicians. Methods: This was a European m
Externí odkaz:
https://doaj.org/article/58b98b728b024679b9fcd7d1a1dd70f7
Autor:
Lukas Krähenbühl, Stephan Krähenbühl
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4365 (2023)
Previous studies showed that rats with long-term bile duct ligation have reduced coenzyme A stores per g of liver but maintained mitochondrial CoA stores. Based on these observations, we determined the CoA pool in the liver homogenate, liver mitochon
Externí odkaz:
https://doaj.org/article/d67366b958b64d63841ad18827fb3a3c
Autor:
Lea S Blaser, Urs Duthaler, Jamal Bouitbir, Anne B Leuppi-Taegtmeyer, Evangelia Liakoni, Reto Dolf, Michael Mayr, Jürgen Drewe, Stephan Krähenbühl, Manuel Haschke
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Aim: The objective was to investigate the effect of metamizole on renal function in healthy, salt-depleted volunteers. In addition, the pharmacokinetics of the four major metamizole metabolites were assessed and correlated with the pharmacodynamic ef
Externí odkaz:
https://doaj.org/article/90f5c5c6045e47539c09d00108323638
Autor:
Katerina Novakova, Michael Török, Miljenko Panajatovic, Jamal Bouitbir, François H. T. Duong, Christoph Handschin, Stephan Krähenbühl
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 20, p 12304 (2022)
OCTN2 (SLC22A5) is a carnitine transporter whose main function is the active transport of carnitine into cells. In skeletal muscle and other organs, the regulation of the SLC22A5 gene transcription has been shown to depend on the nuclear transcriptio
Externí odkaz:
https://doaj.org/article/0f6eec077f364538bfe73399a52acaae
Autor:
Urs Duthaler, Michael Weber, Lorenz Hofer, Carlos Chaccour, Marta Maia, Pie Müller, Stephan Krähenbühl, Felix Hammann
Publikováno v:
PLoS Pathogens, Vol 17, Iss 3, p e1009382 (2021)
Mosquitoes are vectors of major diseases such as dengue fever and malaria. Mass drug administration of endectocides to humans and livestock is a promising complementary approach to current insecticide-based vector control measures. The aim of this st
Externí odkaz:
https://doaj.org/article/73d707be43ef42c1b180197c2f8523b8
Autor:
Sarah Banholzer, Lea Dunkelmann, Manuel Haschke, Adrian Derungs, Aristomenis Exadaktylos, Stephan Krähenbühl, Evangelia Liakoni
Publikováno v:
Swiss Medical Weekly, Vol 151, Iss 0304 (2021)
AIMS OF THE STUDY Adverse drug reactions (ADRs) are an important cause of hospital admissions. Insufficient data are available about the frequency and characteristics of ADR-related emergency readmissions in Switzerland. The aim of this retrospectiv
Externí odkaz:
https://doaj.org/article/f82f09697db94dd7a071a9c2171eb62e
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 4, p 2282 (2022)
Tyrosine kinase inhibitors (TKIs) are associated with cardiac toxicity, which may be caused by mitochondrial toxicity. The underlying mechanisms are currently unclear and require further investigation. In the present study, we aimed to investigate in
Externí odkaz:
https://doaj.org/article/471c7a6061384b2aa0aa5fa644f0e1e1
Autor:
Jamal Bouitbir, Miljenko Valentin Panajatovic, Theo Frechard, Noëmi Johanna Roos, Stephan Krähenbühl
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Tyrosine kinase inhibitors (TKIs) can cause skeletal muscle toxicity in patients, but the underlying mechanisms are mostly unclear. The goal of the current study was to better characterize the role of mitochondria in TKI-associated myotoxicity. We ex
Externí odkaz:
https://doaj.org/article/d08aa1bd952e46a3a84c2130decfb8e6
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
The receptor tyrosine kinase inhibitor lapatinib, indicated to treat patients with HER2-positive breast cancer in combination with capecitabine, can cause severe hepatotoxicity. Lapatinib is further associated with mitochondrial toxicity and accumula
Externí odkaz:
https://doaj.org/article/304488ceebe54538b7c33266ec95e3f0
Autor:
Philipp Krisai, Deborah Rudin, David Grünig, Kathrin Scherer, Werner Pichler, Luigi Terracciano, Stephan Krähenbühl
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
We report on a patient who developed acute liver failure while being treated with metamizole. After liver transplantation, the patient recovered rapidly. Liver biopsy showed massive necrosis and lobular infiltration of lymphocytes. A lymphocyte trans
Externí odkaz:
https://doaj.org/article/07f5cf093dbe4fb49f66759f82a8f23c