Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Stephan Kissler"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Type 1 diabetes (T1D) arises from autoimmune-mediated destruction of insulin-producing pancreatic beta cells. Recent advancements in the technology of generating pancreatic beta cells from human pluripotent stem cells (SC-beta cells) have facilitated
Externí odkaz:
https://doaj.org/article/ef7d93fd837c46f9bf4b266d6a3d535f
Autor:
Cornelia Schuster, Badr Kiaf, Teri Hatzihristidis, Anna Ruckdeschel, Janice Nieves-Bonilla, Yuki Ishikawa, Bin Zhao, Peilin Zheng, Paul E. Love, Stephan Kissler
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
CD5 is constitutively expressed on all T cells and is a negative regulator of lymphocyte function. However, the full extent of CD5 function in immunity remains unclear. CD5 deficiency impacts thymic selection and extra-thymic regulatory T cell genera
Externí odkaz:
https://doaj.org/article/a8a4974b10fa4294a86c90e79d3bac37
Autor:
Stephan Kissler
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Type 1 diabetes (T1D) is caused by the T cell-driven autoimmune destruction of insulin-producing cells in the pancreas. T1D served as the prototypical autoimmune disease for genome wide association studies (GWAS) after having already been the subject
Externí odkaz:
https://doaj.org/article/cc778af4472342c4b5e70737c78648ac
Autor:
Kevin Bode, Tara MacDonald, Taylor Stewart, Bryhan Mendez, Erica P. Cai, Noelle Morrow, Yu-Chi Lee, Peng Yi, Stephan Kissler
Publikováno v:
Diabetes.
Type 1 diabetes (T1D) is caused by the immune-mediated loss of pancreatic beta cells that produce insulin. The latest advances in stem cell (SC)-beta cell differentiation methods have made a cell replacement therapy for T1D feasible. However, recurri
Autor:
Stephan Kissler, Peng Yi, Yu-Chi Lee, Noelle Morrow, Erica P. Cai, Bryhan Mendez, Taylor Stewart, Tara MacDonald, Kevin Bode
Type 1 diabetes (T1D) is caused by the immune-mediated loss of pancreatic beta cells that produce insulin. The latest advances in stem cell (SC)-beta cell differentiation methods have made a cell replacement therapy for T1D feasible. However, recurri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ab250618349bd5772c3a1ed9c97edd3
https://doi.org/10.2337/figshare.22898705.v1
https://doi.org/10.2337/figshare.22898705.v1
Publikováno v:
bioRxiv
Regulatory T cells (Tregs) protect against autoimmunity. In type 1 diabetes (T1D), Tregs slow the progression of beta cell autoimmunity within pancreatic islets. Increasing the potency or frequency of Tregs can prevent diabetes, as evidenced by studi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3de6d2f1abe23094986f6f143bfa3688
https://doi.org/10.1101/2023.03.18.533297
https://doi.org/10.1101/2023.03.18.533297
Publikováno v:
Journal of Visualized Experiments.
Type 1 diabetes is characterized by the autoimmune destruction of the insulin-producing beta cells of the pancreas. A promising treatment for this disease is the transplantation of stem cell-derived beta cells. Genetic modifications, however, may be
Autor:
Stephan Kissler
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Autor:
Jian Li, Peng Yi, Nayara C. Leite, Nese Kurt Yilmaz, Yuki Ishikawa, Jennifer Hollister-Lock, Stephan Kissler, Erica P. Cai, Douglas A. Melton, Badr Kiaf, Wei Zhang, Shurong Hou, Celia A. Schiffer
Publikováno v:
Nature metabolism
Type 1 diabetes (T1D) is caused by the autoimmune destruction of pancreatic beta cells. Pluripotent stem cells can now be differentiated into beta cells, thus raising the prospect of a cell replacement therapy for T1D. However, autoimmunity would rap
Autor:
Feng Shao, Stephan Kissler, Zhixia Li, Lijing Jia, Zhiguang Zhou, Peilin Zheng, Junbin Liu, Xiajie Shi, Lin Kang
Publikováno v:
Endocrine. 67:535-543
A coding variant in PTPN22 (C1858T) is one of the most important genetic risk factors in type 1 diabetes (T1D). The role of the PTPN22 risk allele in B cells is still incompletely understood and has not been investigated directly in T1D. This study a