Výsledky vyhledávání - "Stephan J. Kempiak"

Molecular mechanisms of invadopodium formation

Autor: Corina Sarmiento, Tadaomi Takenawa, Salvatore J. Coniglio, Marc Symons, John S. Condeelis, Robert J. Eddy, Hideki Yamaguchi, Jeffrey E. Segall, Mike Lorenz, Hiroaki Miki, Stephan J. Kempiak

Publikováno v: The Journal of Cell Biology

Invadopodia are actin-rich membrane protrusions with a matrix degradation activity formed by invasive cancer cells. We have studied the molecular mechanisms of invadopodium formation in metastatic carcinoma cells. Epidermal growth factor (EGF) recept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbdbd2eb8735f40d149c2e655a046608
http://europepmc.org/articles/PMC2171731

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Local signaling by the EGF receptor

Autor: Stephan J. Kempiak, Shu Chin Yip, Jeffrey E. Segall, Jonathan M. Backer

Publikováno v: The Journal of Cell Biology

Differing spatial scales of signaling cascades are critical for cell orientation during chemotactic responses. We used biotin EGF bound to streptavidin-coupled magnetic beads to locally stimulate cells overexpressing the EGF receptor. We have found t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3abf6a4d2ce53dadf9716735429ebe6
https://doi.org/10.1083/jcb.200303144

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Primary Human CD4+ T Cells Contain Heterogeneous IκB Kinase Complexes: Role in Activation of the IL-2 Promoter

Autor: Ali Khoshnan, Stephan J. Kempiak, Brydon L. Bennett, David Bae, Weiming Xu, Anthony M. Manning, Carl H. June, Andre E. Nel

Publikováno v: The Journal of Immunology. 163:5444-5452

NF-κB transcription factors play an important role in the activation of the IL-2 gene in response to TCR ligation. The release of NF-κB factors to the nucleus requires phosphorylation and degradation of the inhibitory κ-B proteins (IκBs). IκBα

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1c2c1a664af57422e19b70439b979eaa
https://doi.org/10.4049/jimmunol.163.10.5444

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The Jun Kinase Cascade Is Responsible for Activating the CD28 Response Element of the IL-2 Promoter: Proof of Cross-Talk with the IκB Kinase Cascade

Autor: Stephan J. Kempiak, Timothy S. Hiura, Andre E. Nel

Publikováno v: The Journal of Immunology. 162:3176-3187

Costimulation of TCR/CD3 and CD28 receptors leads to activation of the Jun kinase (JNK) cascade, which plays a key role in T cell activation, including activation of the IL-2 promoter. We demonstrate that the JNK cascade plays a central role in the a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0a42fe0c33d6ed27103c90fb501feca0
https://doi.org/10.4049/jimmunol.162.6.3176

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Sea urchin granuloma secondary to Strongylocentrotus purpuratus and Strongylocentrotus franciscanus

Autor: Filamer D, Kabigting, Stephan J, Kempiak, Doru T, Alexandrescu, Benajmin D, Yu

Publikováno v: Dermatology online journal. 15(5)

Sea urchin injuries have been associated with a variety of cutaneous lesions, ranging from acute, transient reactions, to more chronic inflammatory conditions that result in the formation of granulomas. Although diverse species of sea urchins have be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::19773f08472bd182b58858e43e3d20c3
https://pubmed.ncbi.nlm.nih.gov/19624987

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Sea urchin granuloma secondary to and

Autor: Stephan J Kempiak, Benajmin D Yu, Filamer D Kabigting, Doru T Alexandrescu

Publikováno v: Kabigting, Filamer D; Kempiak, Stephan J; Alexandrescu, Doru T; & Yu, Benajmin D. (2009). Sea urchin granuloma secondary to and. Dermatology Online Journal, 15(5). Retrieved from: http://www.escholarship.org/uc/item/1897s3fg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b1fcbd2c9a99cb1ad16abf22effff82
http://www.escholarship.org/uc/item/1897s3fg

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A neural Wiskott-Aldrich Syndrome protein-mediated pathway for localized activation of actin polymerization that is regulated by cortactin

Autor: Michael Way, Robert J. Eddy, Jeffrey E. Segall, John S. Condeelis, Mousumi Ghosh, Stephan J. Kempiak, Hideki Yamaguchi, Vera DesMarais, Corina Sarmiento, Mazen Sidani

Publikováno v: The Journal of biological chemistry. 280(7)

Activation of the epidermal growth factor (EGF) receptor can stimulate actin polymerization via the Arp2/3 complex using a number of signaling pathways, and specific stimulation conditions may control which pathways are activated. We have previously

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cb4493122104ac08e506e0b4f035097
https://pubmed.ncbi.nlm.nih.gov/15579908

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Stimulation of Cells Using EGF-Coated Magnetic Beads

Autor: Stephan J. Kempiak, Jeffrey E. Segall

Publikováno v: Science's STKE. 2004

The ability to determine the spatial localization of signals can assist in defining the regulation of specific signaling pathways within the cell. Localized application of a stimulus, followed by imaging of various proteins or their phosphorylated pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e6ed533a0a510936882ef01927ace07
https://doi.org/10.1126/stke.2182004pl1

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Activation of the human RANTES gene promoter in a macrophage cell line by lipopolysaccharide is dependent on stress-activated protein kinases and the IkappaB kinase cascade: implications for exacerbation of allergic inflammation by environmental pollutants

Autor: Timothy S. Hiura, Stephan J. Kempiak, Andre E. Nel

Publikováno v: Clinical immunology (Orlando, Fla.). 90(3)

Macrophages are targeted by environmental pollutants and play a role in allergic inflammation. We explored the molecular basis for induction of RANTES (regulated upon activation, normal T-cells expressed and secreted) mRNA by lipopolysaccharide (LPS)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::196fdd1573cefed722999536da863891
https://pubmed.ncbi.nlm.nih.gov/10075857

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Stress-Induced Fas Ligand Expression in T Cells Is Mediated through a MEK Kinase 1-Regulated Response Element in the Fas Ligand Promoter

Autor: Gary A. Koretzky, Kevin M. Latinis, Stephan J. Kempiak, Andre E. Nel, Mary Faris

T lymphocytes undergo apoptosis in response to a variety of stimuli, including exposure to UV radiation and gamma-irradiation. While the mechanism by which stress stimuli induce apoptosis is not well understood, we have previously shown that the indu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9de2984f5249c6f552db26a39b5996a7
https://europepmc.org/articles/PMC109126/

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