Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Stephan J, Kempiak"'
Autor:
Corina Sarmiento, Tadaomi Takenawa, Salvatore J. Coniglio, Marc Symons, John S. Condeelis, Robert J. Eddy, Hideki Yamaguchi, Jeffrey E. Segall, Mike Lorenz, Hiroaki Miki, Stephan J. Kempiak
Publikováno v:
The Journal of Cell Biology
Invadopodia are actin-rich membrane protrusions with a matrix degradation activity formed by invasive cancer cells. We have studied the molecular mechanisms of invadopodium formation in metastatic carcinoma cells. Epidermal growth factor (EGF) recept
Publikováno v:
The Journal of Cell Biology
Differing spatial scales of signaling cascades are critical for cell orientation during chemotactic responses. We used biotin EGF bound to streptavidin-coupled magnetic beads to locally stimulate cells overexpressing the EGF receptor. We have found t
Autor:
Ali Khoshnan, Stephan J. Kempiak, Brydon L. Bennett, David Bae, Weiming Xu, Anthony M. Manning, Carl H. June, Andre E. Nel
Publikováno v:
The Journal of Immunology. 163:5444-5452
NF-κB transcription factors play an important role in the activation of the IL-2 gene in response to TCR ligation. The release of NF-κB factors to the nucleus requires phosphorylation and degradation of the inhibitory κ-B proteins (IκBs). IκBα
Publikováno v:
The Journal of Immunology. 162:3176-3187
Costimulation of TCR/CD3 and CD28 receptors leads to activation of the Jun kinase (JNK) cascade, which plays a key role in T cell activation, including activation of the IL-2 promoter. We demonstrate that the JNK cascade plays a central role in the a
Publikováno v:
Dermatology online journal. 15(5)
Sea urchin injuries have been associated with a variety of cutaneous lesions, ranging from acute, transient reactions, to more chronic inflammatory conditions that result in the formation of granulomas. Although diverse species of sea urchins have be
Publikováno v:
Kabigting, Filamer D; Kempiak, Stephan J; Alexandrescu, Doru T; & Yu, Benajmin D. (2009). Sea urchin granuloma secondary to and. Dermatology Online Journal, 15(5). Retrieved from: http://www.escholarship.org/uc/item/1897s3fg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b1fcbd2c9a99cb1ad16abf22effff82
http://www.escholarship.org/uc/item/1897s3fg
http://www.escholarship.org/uc/item/1897s3fg
Autor:
Michael Way, Robert J. Eddy, Jeffrey E. Segall, John S. Condeelis, Mousumi Ghosh, Stephan J. Kempiak, Hideki Yamaguchi, Vera DesMarais, Corina Sarmiento, Mazen Sidani
Publikováno v:
The Journal of biological chemistry. 280(7)
Activation of the epidermal growth factor (EGF) receptor can stimulate actin polymerization via the Arp2/3 complex using a number of signaling pathways, and specific stimulation conditions may control which pathways are activated. We have previously
Autor:
Stephan J. Kempiak, Jeffrey E. Segall
Publikováno v:
Science's STKE. 2004
The ability to determine the spatial localization of signals can assist in defining the regulation of specific signaling pathways within the cell. Localized application of a stimulus, followed by imaging of various proteins or their phosphorylated pr
Publikováno v:
Clinical immunology (Orlando, Fla.). 90(3)
Macrophages are targeted by environmental pollutants and play a role in allergic inflammation. We explored the molecular basis for induction of RANTES (regulated upon activation, normal T-cells expressed and secreted) mRNA by lipopolysaccharide (LPS)
T lymphocytes undergo apoptosis in response to a variety of stimuli, including exposure to UV radiation and gamma-irradiation. While the mechanism by which stress stimuli induce apoptosis is not well understood, we have previously shown that the indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9de2984f5249c6f552db26a39b5996a7
https://europepmc.org/articles/PMC109126/
https://europepmc.org/articles/PMC109126/