Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Stephan Hamperl"'
Publikováno v:
Nucleus, Vol 14, Iss 1 (2023)
ABSTRACTIn eukaryotic genomes, hundreds to thousands of potential start sites of DNA replication named origins are dispersed across each of the linear chromosomes. During S-phase, only a subset of origins is selected in a stochastic manner to assembl
Externí odkaz:
https://doaj.org/article/68b43a95fad741309285e0af52a92796
Autor:
Matthias Weiβ, Anna Chanou, Tamas Schauer, Andrey Tvardovskiy, Stefan Meiser, Ann-Christine König, Tobias Schmidt, Elisabeth Kruse, Henning Ummethum, Manuel Trauner, Marcel Werner, Maxime Lalonde, Stefanie M. Hauck, Antonio Scialdone, Stephan Hamperl
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112045- (2023)
Summary: The chromatin environment at origins of replication is thought to influence DNA replication initiation in eukaryotic genomes. However, it remains unclear how and which chromatin features control the firing of early-efficient (EE) or late-ine
Externí odkaz:
https://doaj.org/article/233b7d8b286e46b5b0c72d74c4bb3234
Autor:
Anna Chanou, Stephan Hamperl
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Besides the basic organization in nucleosome core particles (NCPs), eukaryotic chromatin is further packed through interactions with numerous protein complexes including transcription factors, chromatin remodeling and modifying enzymes. This nucleopr
Externí odkaz:
https://doaj.org/article/7347caa3a38d403290699d271c67b747
Autor:
Henning Ummethum, Stephan Hamperl
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
Mammals contain over 200 different cell types, yet nearly all have the same genomic DNA sequence. It is a key question in biology how the genetic instructions in DNA are selectively interpreted by cells to specify various transcriptional programs and
Externí odkaz:
https://doaj.org/article/df2f24b0fa61459f81f0aec11443a416
Publikováno v:
Life, Vol 11, Iss 7, p 637 (2021)
Transcription–replication conflicts occur when the two critical cellular machineries responsible for gene expression and genome duplication collide with each other on the same genomic location. Although both prokaryotic and eukaryotic cells have ev
Externí odkaz:
https://doaj.org/article/da56289728fa41258f953ea03836cf95
Autor:
Dagmar Pich, Paulina Mrozek-Gorska, Mickaël Bouvet, Atsuko Sugimoto, Ezgi Akidil, Adam Grundhoff, Stephan Hamperl, Paul D. Ling, Wolfgang Hammerschmidt
Publikováno v:
mBio, Vol 10, Iss 5 (2019)
ABSTRACT Epstein-Barr virus (EBV) infects and activates resting human B lymphocytes, reprograms them, induces their proliferation, and establishes a latent infection in them. In established EBV-infected cell lines, many viral latent genes are express
Externí odkaz:
https://doaj.org/article/44af517b4c2d4cc5aeabf29c7336daf8
Autor:
Shiva Bamezai, Alex Jose Pulikkottil, Tribhuwan Yadav, Vegi Mahalakshmi Naidu, Julia Mueller, Jasmin Mark, Tamoghna Mandal, Kristin Anja Feder, Susann Lehle, Chenlin Song, Reinhild Rosler, Sebastian Wiese, Jessica I Hoell, Andreas Kloetgen, Aly Karsan, Ankita Kumari, Luke Wojenski, Amit U Sinha, Irene Gonzalez-Menendez, Leticia Quintanilla-Martinez, Elisa Donato, Andreas Trumpp, Elisabeth Kruse, Stephan Hamperl, Lee Zou, Vijay P. S. Rawat, Christian Buske
Publikováno v:
Blood Journal.
RNA-binding proteins (RBPs) form a large and diverse class of factors many members of which are overexpressed in hematological malignancies. RBPs participate in various processes of mRNA metabolism and prevent harmful DNA:RNA hybrids or R-loops. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8e114e7128a4dc3c179a25db86e6ef9
https://doi.org/10.1182/blood.2022018651
https://doi.org/10.1182/blood.2022018651
Autor:
Anna Chanou, Matthias Weiβ, Karoline Holler, Tobias Straub, Jana Krietsch, Andrea Sanchi, Henning Ummethum, Clare S. K. Lee, Elisabeth Kruse, Manuel Trauner, Marcel Werner, Maxime Lalonde, Massimo Lopes, Antonio Scialdone, Stephan Hamperl
Summary:Stochastic origin activation gives rise to significant cell-to-cell variability in the pattern of genome replication. The molecular basis for heterogeneity in efficiency and timing of individual origins is a long-standing question. Here, we d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78a18e71b30b1d6613fb08b7feea06cf
https://doi.org/10.1101/2023.03.14.532513
https://doi.org/10.1101/2023.03.14.532513
Autor:
Henning Ummethum, Maxime Lalonde, Marcel Werner, Manuel Trauner, Anna Chanou, Matthias Weiβ, Clare S. K. Lee, Elisabeth Kruse, Andreas Ettinger, Stephan Hamperl
SummaryShort tracts of trinucleotide repeats with less than 10 repeats are found frequently throughout the genome without any apparent negative impact on DNA replication fork progression or transcription elongation. CGG binding protein 1 (CGGBP1) bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8bf3d5b951dcce6bb3d5570a5b460dc
https://doi.org/10.1101/2023.03.09.531843
https://doi.org/10.1101/2023.03.09.531843
Autor:
Stephan Hamperl, Elisabeth Kruse
Publikováno v:
BioSpektrum 27, 246-249 (2021)
Timely and accurate duplication of DNA prior to cell division is a prerequisite for propagation of the genetic material to both daughter cells. DNA synthesis initiates at discrete sites, termed replication origins, and proceeds in a bidirectional man
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49ccd8e119a973a910c73f8423962802
https://doi.org/10.1007/s12268-021-1562-z
https://doi.org/10.1007/s12268-021-1562-z