Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Stephan Hailfinger"'
Autor:
Jens Bauer, Natalie Köhler, Yacine Maringer, Philip Bucher, Tatjana Bilich, Melissa Zwick, Severin Dicks, Annika Nelde, Marissa Dubbelaar, Jonas Scheid, Marcel Wacker, Jonas S. Heitmann, Sarah Schroeder, Jonas Rieth, Monika Denk, Marion Richter, Reinhild Klein, Irina Bonzheim, Julia Luibrand, Ursula Holzer, Martin Ebinger, Ines B. Brecht, Michael Bitzer, Melanie Boerries, Judith Feucht, Helmut R. Salih, Hans-Georg Rammensee, Stephan Hailfinger, Juliane S. Walz
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The DNAJB1-PRKACA fusion transcript is the oncogenic driver in fibrolamellar hepatocellular carcinoma, a lethal disease with limited therapeutic options. Here, the authors identify the DNAJB1-PRKACA protein as a source for immunogenic neoepitopes and
Externí odkaz:
https://doaj.org/article/3a134c49c74b482cbf740f80cccba049
Autor:
Michael Heming, Svea Haessner, Jolien Wolbert, I-Na Lu, Xiaolin Li, Benjamin Brokinkel, Michael Müther, Markus Holling, Walter Stummer, Christian Thomas, Andreas Schulte-Mecklenbeck, Flavia de Faria, Marlon Stoeckius, Stephan Hailfinger, Georg Lenz, Kornelius Kerl, Heinz Wiendl, Gerd Meyer zu Hörste, Oliver M. Grauer
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-19 (2022)
Abstract Background Primary central nervous system lymphoma (PCNSL) is a rare lymphoma of the central nervous system, usually of diffuse large B cell phenotype. Stereotactic biopsy followed by histopathology is the diagnostic standard. However, limit
Externí odkaz:
https://doaj.org/article/f469e31eaaf1475f9487cd81a7d88824
Autor:
Hannes Schmid, Emmanuelle M. Ribeiro, Kathy-Ann Secker, Silke Duerr-Stoerzer, Hildegard Keppeler, Ruoyun Dong, Timo Munz, Klaus Schulze-Osthoff, Stephan Hailfinger, Corina Schneidawind, Dominik Schneidawind
Publikováno v:
Haematologica, Vol 107, Iss 2 (2021)
Graft-versus-host disease (GvHD) is a major cause of morbidity and mortality after allogeneic hematopoietic cell transplantation. We recently showed in murine studies and in vitro human models that adoptively transferred invariant natural killer T (i
Externí odkaz:
https://doaj.org/article/a686e7eee464476fa80c786a7985aa39
Publikováno v:
Biomedicines, Vol 10, Iss 2, p 344 (2022)
Almost twenty years ago, the importance of the paracaspase MALT1 in antigen receptor-induced NF-κB activation was first described. Since then, several other immune receptors, G-protein-coupled receptors, and receptor tyrosine kinases were identified
Externí odkaz:
https://doaj.org/article/866060f0158b4346aedcc7135c945fc3
Autor:
Julia Nehls, Ramona Businger, Markus Hoffmann, Constantin Brinkmann, Birgit Fehrenbacher, Martin Schaller, Brigitte Maurer, Caroline Schönfeld, Daniela Kramer, Stephan Hailfinger, Stefan Pöhlmann, Michael Schindler
Publikováno v:
Cell Reports, Vol 26, Iss 7, Pp 1841-1853.e6 (2019)
Summary: The Ebola virus glycoprotein (EBOV-GP) forms GP-containing microvesicles, so-called virosomes, which are secreted from GP-expressing cells. However, determinants of GP-virosome release and their functionality are poorly understood. We charac
Externí odkaz:
https://doaj.org/article/07bc6b29896e4290af031e69a39cda9f
Publikováno v:
Biomedicines, Vol 6, Iss 2, p 38 (2018)
The NF-κB transcription factor family plays a crucial role in lymphocyte proliferation and survival. Consequently, aberrant NF-κB activation has been described in a variety of lymphoid malignancies, including diffuse large B-cell lymphoma, Hodgkin
Externí odkaz:
https://doaj.org/article/58fd34cfe02245158776165ca5624eee
Autor:
Katrin Cabalzar, Christiane Pelzer, Annette Wolf, Georg Lenz, Justyna Iwaszkiewicz, Vincent Zoete, Stephan Hailfinger, Margot Thome
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72051 (2013)
The mucosa-associated lymphoid tissue protein-1 (MALT1, also known as paracaspase) is a protease whose activity is essential for the activation of lymphocytes and the growth of cells derived from human diffuse large B-cell lymphomas of the activated
Externí odkaz:
https://doaj.org/article/d7c2cbc8206849c79c88b14a8c5cd3a6
Publikováno v:
Leukemia & Lymphoma. 64:799-807
Plasmablastic lymphoma (PBL) represents a rare distinct lymphoma entity with plasmablastic morphology and plasmacytic immunophenotype that is characterized by an aggressive clinical course. Standard chemotherapeutic regimens often remain insufficient
Autor:
Kaiyan Sun, Ling Jin, Jana Karolová, Jan Vorwerk, Stephan Hailfinger, Bertram Opalka, Myroslav Zapukhlyak, Georg Lenz, Cyrus Khandanpour
Publikováno v:
Cancers; Volume 15; Issue 8; Pages: 2373
Multiple myeloma (MM) is an incurable, malignant B cell disorder characterized by frequent relapses and a poor prognosis. Thus, new therapeutic approaches are warranted. The phosphatidylinositol-3-kinase (PI3K) pathway plays a key role in many critic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cce67be0f5f11d09b222ecd292dcf519
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85153955325
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85153955325
Autor:
Fabian Frontzek, Annette M. Staiger, Ramona Wullenkord, Michael Grau, Myroslav Zapukhlyak, Katrin S. Kurz, Heike Horn, Tabea Erdmann, Falko Fend, Julia Richter, Wolfram Klapper, Peter Lenz, Stephan Hailfinger, Anna Tasidou, Marcel Trautmann, Wolfgang Hartmann, Andreas Rosenwald, Leticia Quintanilla-Martinez, German Ott, Ioannis Anagnostopoulos, Georg Lenz
Publikováno v:
Leukemia.
Epstein-Barr virus (EBV) associated diffuse large B-cell lymphoma (DLBCL) represents a rare aggressive B-cell lymphoma subtype characterized by an adverse clinical outcome. EBV infection of lymphoma cells has been associated with different lymphoma s