Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Stephan H. Spangenberg"'
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100400- (2021)
Summary: Flow cytometry is a valuable method for analyzing protein expressions at the single cell level but can be difficult to apply to large numbers of samples. This protocol provides instructions to perform a high-throughput small molecule screen
Externí odkaz:
https://doaj.org/article/a51ceb7a0cc740b0b7890bea63047747
Autor:
Jae Wook Lee, Paul S. Mischel, Stephen Skirboll, Natasha C. Lucki, Luke L. Lairson, Heiko Wurdak, Kevin Johnson, Brittney A. Beyer, Philipp N. Sander, Genaro R. Villa, Naja Vergani, Peter G. Schultz, Stephan H. Spangenberg, Perry Gordon, Michael J. Bollong, Emily N. Chin, Amandeep Sharma, Justin L. Anglin
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 13
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
Significance We have completed a screen of ∼106 small molecules to identify compounds that induce cell death in multipotent glioblastoma multiforme (GBM) cancer stem cells (CSCs). This resulted in the identification of a hit class (RIPGBM) that was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27327ca5e9255a5143893ff0a327f8dd
https://doi.org/10.1073/pnas.1816626116
https://doi.org/10.1073/pnas.1816626116
Publikováno v:
STAR Protocols
STAR Protocols, Vol 2, Iss 2, Pp 100400-(2021)
STAR Protocols, Vol 2, Iss 2, Pp 100400-(2021)
Summary Flow cytometry is a valuable method for analyzing protein expressions at the single cell level but can be difficult to apply to large numbers of samples. This protocol provides instructions to perform a high-throughput small molecule screen u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4b7fbda1ff19eebd85c2cecec3b14f9
https://pubmed.ncbi.nlm.nih.gov/33778785
https://pubmed.ncbi.nlm.nih.gov/33778785
Autor:
Genaro Villa, Michael J. Bollong, Phillipp Sander, Heiko Wurdak, Brittney A. Beyer, Stephan H. Spangenberg, Justin L. Anglin, Peter G. Schultz, Luke L. Lairson, Natasha C. Lucki, Emily N. Chin, Amandeep Sharma, Stephen Skirboll, Perry Gordon, Naja Vergani, Jae Wook Lee, Paul S. Mischel, Kevin Johnson
Publikováno v:
Neuro Oncol
INTRODUCTION Glioblastoma multiforme (GBM) is the most aggressive form of primary brain cancer. A subpopulation of multipotent cells termed GBM cancer stem cells (CSCs) play a critical role in tumor initiation and maintenance, drug resistance, and re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4acfd2cd779b5e6a3b66f5b684e931bc
https://europepmc.org/articles/PMC7651318/
https://europepmc.org/articles/PMC7651318/
Autor:
Luke L. Lairson, Stephan H. Spangenberg, Francisco Martínez-Peña, Ashley K. Woods, Reza Beheshti Zavareh
Publikováno v:
Cell Chemical Biology. 28:158-168.e5
Summary Cancer immunotherapies, including immune checkpoint blockade, have the potential to significantly impact treatments for diverse tumor types. At present, response failures and immune-related adverse events remain significant issues, which coul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec5acba4d2816272489be9450eeb7d3b
https://doi.org/10.1016/j.chembiol.2020.10.005
https://doi.org/10.1016/j.chembiol.2020.10.005
Publikováno v:
Biophysical Journal. 116:308a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4beb13cd5d73a95a58cd708881d66460
https://doi.org/10.1016/j.bpj.2018.11.1667
https://doi.org/10.1016/j.bpj.2018.11.1667