Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Stephan Gromer"'
Autor:
Kathrin Buchholz, R. Luise Krauth-Siegel, Marcelo A. Comini, Dirk Wissenbach, Stephan Gromer, R. Heiner Schirmer
Publikováno v:
Molecular and Biochemical Parasitology. 160:65-69
Methylene blue (MB) is known to have trypanocidal activity. We tested the interactions of MB with a number of trypanosomatid-specific molecules of the antioxidant metabolism. At pH 7, trypanothione and other (di)thiols were oxidized to disulfides by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8303c48a9e4a51fc9903c884dfb7b4b2
https://doi.org/10.1016/j.molbiopara.2008.03.006
https://doi.org/10.1016/j.molbiopara.2008.03.006
Publikováno v:
ChemBioChem. 7:1649-1652
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ed8aa05a6f80b7b4d7c4e1bbdfe81ae
https://doi.org/10.1002/cbic.200600080
https://doi.org/10.1002/cbic.200600080
Autor:
Karen S. Anderson, R. Heiner Schirmer, Chloé E. Atreya, Worachart Sirawaraporn, Keith A. Joiner, Lanxuan T. Doan, Stephan Gromer, Michael T. McIntosh, Kristen M. Massimine, David A. Elliott
Publikováno v:
Antimicrobial Agents and Chemotherapy. 50:3132-3141
4′,5′-Dibromo-2′,7′-dinitrofluorescein, a red dye commonly referred to as eosin B, inhibits Toxoplasma gondii in both enzymatic and cell culture studies with a 50% inhibitory concentration (IC 50 ) of 180 μM. As a non-active-site inhibitor o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abf1484ad417d1d44c107525080ed966
https://doi.org/10.1128/aac.00621-06
https://doi.org/10.1128/aac.00621-06
Autor:
Alexey V. Lobanov, Dolph L. Hatfield, Stephan Gromer, Cesar Delgado, Sergey V. Novoselov, Vadim N. Gladyshev, Gregory V. Kryukov, Stefan Rahlfs, Katja Becker
Publikováno v:
Nucleic Acids Research
The use of selenocysteine (Sec) as the 21st amino acid in the genetic code has been described in all three major domains of life. However, within eukaryotes, selenoproteins are only known in animals and algae. In this study, we characterized selenopr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::981b11b21a3af59018d1d0f3d5269587
http://europepmc.org/articles/PMC1342035
http://europepmc.org/articles/PMC1342035
Autor:
Jürgen H. Gross, Stephan Gromer
Publikováno v:
Journal of Biological Chemistry. 277:9701-9706
Biochemical and clinical evidence indicates that monomethylated selenium compounds are crucial for the tumor preventive effects of the trace element selenium and that methylselenol (CH(3)SeH) is a key metabolite. As suggested by Ganther (Ganther, H.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57e80edc837982d5d6aed6b6238ec3ea
https://doi.org/10.1074/jbc.m109234200
https://doi.org/10.1074/jbc.m109234200
Publikováno v:
European Journal of Biochemistry. 267:6118-6125
Human cytosolic thioredoxin reductase (TrxR), a homodimeric protein containing 1 selenocysteine and 1 FAD per subunit of 55 kDa, catalyses the NADPH-dependent reduction of thioredoxin disulfide and of numerous other oxidized cell constituents. As a g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::819cf0209104843df92046fc0383c0db
https://doi.org/10.1046/j.1432-1327.2000.01703.x
https://doi.org/10.1046/j.1432-1327.2000.01703.x
Publikováno v:
Redox Report. 4:221-228
(1999). News and views on thioredoxin reductases. Redox Report: Vol. 4, No. 5, pp. 221-228.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd5b8729973991a8f0eeee26e680f960
https://doi.org/10.1179/135100099101534936
https://doi.org/10.1179/135100099101534936
Autor:
Katja Becker, Stephan Gromer, Stefan Rahlfs, Kathleen Zocher, Sergio Wittlin, Denis Kasozi, R.H. Schirmer, Heike Adler, Karin Fritz-Wolf
Publikováno v:
Redox Report
The quorum sensor and signalling molecule pyocyanin (PYO) contributes significantly to the pathophysiology of Pseudomonas aeruginosa infections. Comparison to phenothiazine drugs suggests that the antimalarial compound methylene blue (MB) can be rega
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bb63b03db5ac798828e1b95c656be3d
http://www.maneyonline.com/doi/pdfplus/10.1179/174329211X13049558293678
http://www.maneyonline.com/doi/pdfplus/10.1179/174329211X13049558293678
Autor:
Katja Becker, Kathrin Buchholz, Thomas Dandekar, Stephan Gromer, Jana Eubel, R. Heiner Schirmer, Monique Akoachere
Methylene blue (MB) has experienced a renaissance mainly as a component of drug combinations against Plasmodium falciparum malaria. Here, we report biochemically relevant pharmacological data on MB such as rate constants for the uncatalyzed reaction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47ee52c930971495b9736f6ef109b965
https://europepmc.org/articles/PMC2223905/
https://europepmc.org/articles/PMC2223905/
Autor:
Martin de Boer, Nanne Kamerbeek, Carsten Lincke, Dirk Roos, Katja Becker, Gert Morren, Rob van Zwieten, Herma Vuil, Natalja Bannink, Koert M. Dolman, Stephan Gromer, R. Heiner Schirmer
Publikováno v:
Blood, 109(8), 3560-3566. American Society of Hematology
Hereditary glutathione reductase (GR) deficiency was found in only 2 cases when testing more than 15 000 blood samples. We have investigated the blood cells of 2 patients (1a and 1b) in a previously described family suffering from favism and cataract
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e876f025abcee08cbc16274f74de9f25
https://pure.amc.nl/en/publications/molecular-basis-of-glutathione-reductase-deficiency-in-human-blood-cells(24836f2b-38bc-4987-a4c4-2e649f26dbf2).html
https://pure.amc.nl/en/publications/molecular-basis-of-glutathione-reductase-deficiency-in-human-blood-cells(24836f2b-38bc-4987-a4c4-2e649f26dbf2).html