Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Stephan G. Zech"'
Autor:
Christopher Fotsch, Debaleena Basu, Ryan Case, Qing Chen, Pratibha C. Koneru, Mei-Chu Lo, Rachel Ngo, Pooja Sharma, Amit Vaish, Xiang Yi, Stephan G. Zech, Peter Hodder
Publikováno v:
SLAS Discovery, Vol 29, Iss 4, Pp 100159- (2024)
To confirm target engagement of hits from our high-throughput screening efforts, we ran biophysical assays on several hundreds of hits from 15 different high-throughput screening campaigns. Analyzing the biophysical assay results from these screening
Externí odkaz:
https://doaj.org/article/2deb87592cfb4d24ab3ef0bdbdb9d00b
Publikováno v:
Accounts of Chemical Research. 55:2892-2903
ConspectusNearly a century after its first description, configurationally stable axial chirality remains a rare feature in marketed drugs. In the development of the KRAS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fa33be4d8cb13730846b9101f1da93e
https://doi.org/10.1021/acs.accounts.2c00479
https://doi.org/10.1021/acs.accounts.2c00479
Autor:
Victor M. Rivera, Xiaotian Zhu, Kwok-kin Wong, Shengwu Liu, Robert J. Griffin, Johara Chouitar, Michael Fitzgerald, William C. Shakespeare, David Dalgarno, Tim Clackson, Narayana I. Narasimhan, Biplab Das, Stephan G. Zech, Matthew T. Greenfield, Feng Li, Yongbo Hu, Wei-Sheng Huang, Sen Zhang, Yaoyu Ning, Sara Nadworny, Scott D. Wardwell, Shuai Li, Alexandra E. Gould, Theresa E. Baker, Sylvie Vincent, Francois Gonzalvez
Most EGFR exon 20 insertion (EGFRex20ins) driver mutations in non–small cell lung cancer (NSCLC) are insensitive to approved EGFR tyrosine kinase inhibitors (TKI). To address the limitations of existing therapies targeting EGFR-mutated NSCLC, moboc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1233d4a09c246c7e577a052bb61a6464
https://doi.org/10.1158/2159-8290.c.6549370.v1
https://doi.org/10.1158/2159-8290.c.6549370.v1
Autor:
Victor M. Rivera, Xiaotian Zhu, Kwok-kin Wong, Shengwu Liu, Robert J. Griffin, Johara Chouitar, Michael Fitzgerald, William C. Shakespeare, David Dalgarno, Tim Clackson, Narayana I. Narasimhan, Biplab Das, Stephan G. Zech, Matthew T. Greenfield, Feng Li, Yongbo Hu, Wei-Sheng Huang, Sen Zhang, Yaoyu Ning, Sara Nadworny, Scott D. Wardwell, Shuai Li, Alexandra E. Gould, Theresa E. Baker, Sylvie Vincent, Francois Gonzalvez
Supplementary Tables (S1-6) and Figures (S1-6)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40b1686b17282cc4afaa22ed044b1306
https://doi.org/10.1158/2159-8290.22540399
https://doi.org/10.1158/2159-8290.22540399
Autor:
Wei-Sheng, Huang, Feng, Li, Yongjin, Gong, Yun, Zhang, Willmen, Youngsaye, Yongjin, Xu, Xiaotian, Zhu, Matthew T, Greenfield, Anna, Kohlmann, Paul M, Taslimi, Angela, Toms, Stephan G, Zech, Tianjun, Zhou, Biplab, Das, Hyun G, Jang, Meera, Tugnait, Yihua E, Ye, Francois, Gonzalvez, Theresa E, Baker, Sara, Nadworny, Yaoyu, Ning, Scott D, Wardwell, Sen, Zhang, Alexandra E, Gould, Yongbo, Hu, Weston, Lane, Robert J, Skene, Hua, Zou, Tim, Clackson, Narayana I, Narasimhan, Victor M, Rivera, David C, Dalgarno, William C, Shakespeare
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 80:129084
In the treatment of non-small cell lung cancer (NSCLC), patients harboring exon 20 insertion mutations in the epidermal growth factor receptor (EGFR) gene (EGFR) have few effective therapies because this subset of mutants is generally resistant to mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36257c29b5ae4b54e2d345df53177fd7
https://doi.org/10.1016/j.bmcl.2022.129084
https://doi.org/10.1016/j.bmcl.2022.129084
Autor:
Brian A. Lanman, Jennifer R. Allen, John G. Allen, Albert K. Amegadzie, Kate S. Ashton, Shon K. Booker, Jian Jeffrey Chen, Ning Chen, Michael J. Frohn, Guy Goodman, David J. Kopecky, Longbin Liu, Patricia Lopez, Jonathan D. Low, Vu Ma, Ana E. Minatti, Thomas T. Nguyen, Nobuko Nishimura, Alexander J. Pickrell, Anthony B. Reed, Youngsook Shin, Aaron C. Siegmund, Nuria A. Tamayo, Christopher M. Tegley, Mary C. Walton, Hui-Ling Wang, Ryan P. Wurz, May Xue, Kevin C. Yang, Pragathi Achanta, Michael D. Bartberger, Jude Canon, L. Steven Hollis, John D. McCarter, Christopher Mohr, Karen Rex, Anne Y. Saiki, Tisha San Miguel, Laurie P. Volak, Kevin H. Wang, Douglas A. Whittington, Stephan G. Zech, J. Russell Lipford, Victor J. Cee
Publikováno v:
Journal of Medicinal Chemistry. 63:52-65
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d131821132bab6ea5628a8639f9d9435
https://doi.org/10.1021/acs.jmedchem.9b01180
https://doi.org/10.1021/acs.jmedchem.9b01180
Autor:
Francois, Gonzalvez, Sylvie, Vincent, Theresa E, Baker, Alexandra E, Gould, Shuai, Li, Scott D, Wardwell, Sara, Nadworny, Yaoyu, Ning, Sen, Zhang, Wei-Sheng, Huang, Yongbo, Hu, Feng, Li, Matthew T, Greenfield, Stephan G, Zech, Biplab, Das, Narayana I, Narasimhan, Tim, Clackson, David, Dalgarno, William C, Shakespeare, Michael, Fitzgerald, Johara, Chouitar, Robert J, Griffin, Shengwu, Liu, Kwok-Kin, Wong, Xiaotian, Zhu, Victor M, Rivera
Publikováno v:
Cancer discovery. 11(7)
Most
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9a090d0d5999a1e6356828f965f2c661
https://pubmed.ncbi.nlm.nih.gov/34284994
https://pubmed.ncbi.nlm.nih.gov/34284994
W-band (95 GHz) electron spin echo envelope modulation (ESEEM) is proposed as a method for simultaneously determining the relative orientation and separation of the constituents of spin-correlated radical pairs in the solid state. The discussion focu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::500c3a80f6c1951dabcdc169daa0c93e
https://ora.ox.ac.uk/objects/uuid:6d0aebb8-b431-46b0-a3f8-fa9ef8bf8802
https://ora.ox.ac.uk/objects/uuid:6d0aebb8-b431-46b0-a3f8-fa9ef8bf8802
Autor:
Stephan G. Zech, Feng Li, Rachel M. Squillace, R. Mathew Thomas, David C. Dalgarno, David Miller, Yihan Wang, Matthew T. Greenfield, Xiaotian Zhu, William C. Shakespeare, Yongjin Xu, Jiwei Qi, Lois Parillon, Tianjun Zhou, Anna Kohlmann, Juan J. Miret
Publikováno v:
Journal of medicinal chemistry. 59(2)
Choline kinase α (ChoKα) is an enzyme involved in the synthesis of phospholipids and thereby plays key roles in regulation of cell proliferation, oncogenic transformation, and human carcinogenesis. Since several inhibitors of ChoKα display antipro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f08ea23a5fe9e235b1147b5ff77d60c
https://pubmed.ncbi.nlm.nih.gov/26700752
https://pubmed.ncbi.nlm.nih.gov/26700752
Autor:
Jaclyn M. Chasse, Qing Deng, Kirsten Overoye-Chan, Peter Caravan, Richard J. Looby, Steffi K. Koerner, Stephan G. Zech, Thomas J. McMurry, Andrew Kolodziej
Publikováno v:
Journal of the American Chemical Society. 130:6025-6039
Thrombus (blood clot) is implicated in a number of life threatening diseases, e.g., heart attack, stroke, pulmonary embolism. EP-2104R is an MRI contrast agent designed to detect thrombus by binding to the protein fibrin, present in all thrombi. EP-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8058c43392a44d69b7fedd70ee463f61
https://doi.org/10.1021/ja800834y
https://doi.org/10.1021/ja800834y