Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Stephan Eismann"'
Autor:
Stephan Eismann, Robert G Endres
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 12, p e1004650 (2015)
The chemotaxis sensory system allows bacteria such as Escherichia coli to swim towards nutrients and away from repellents. The underlying pathway is remarkably sensitive in detecting chemical gradients over a wide range of ambient concentrations. Int
Externí odkaz:
https://doaj.org/article/0cd352bff4f74682a31d26c13e0e0d03
Publikováno v:
Proteins: Structure, Function, and Bioinformatics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e43b33a09b00dfe1607277f45f8b958b
https://doi.org/10.1002/prot.26494
https://doi.org/10.1002/prot.26494
Autor:
Bowen Jing, Raphael J. L. Townshend, Nathaniel Thomas, Milind Jagota, Ron O. Dror, Stephan Eismann
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 89:493-501
Predicting the structure of multi-protein complexes is a grand challenge in biochemistry, with major implications for basic science and drug discovery. Computational structure prediction methods generally leverage pre-defined structural features to d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::705fb5826b4d04d338b9c71d36bc1d3c
https://doi.org/10.1002/prot.26033
https://doi.org/10.1002/prot.26033
Autor:
Ron O. Dror, Andrew M. Watkins, Ramya Rangan, Raphael J. L. Townshend, Stephan Eismann, Rhiju Das, Maria Karelina
Publikováno v:
Science
RNA molecules adopt three-dimensional structures that are critical to their function and of interest in drug discovery. Few RNA structures are known, however, and predicting them computationally has proven challenging. We introduce a machine learning
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92b342e29ae6f911def1b74e67c1d644
https://europepmc.org/articles/PMC9829186/
https://europepmc.org/articles/PMC9829186/
Autor:
Alissa L. W. Kleinhenz, Matthew C. King, Naomi R. Latorraca, Carl-Mikael Suomivuori, Robert J. Lefkowitz, Stephan Eismann, Ron O. Dror, Meredith A. Skiba, Andrew C. Kruse, Laura M. Wingler, Dean P. Staus
Publikováno v:
Science
Choosing the drug to fit the protein Many approved drugs bind to G protein–coupled receptors (GPCRs). A challenge in targeting GPCRs is that different ligands preferentially activate different signaling pathways. Two papers show how biased signalin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c630ae3efc9ed2a68c9d366e2c62f34
https://europepmc.org/articles/PMC7259329/
https://europepmc.org/articles/PMC7259329/
Autor:
Stephan Eismann, Alissa L. W. Kleinhenz, Andrew C. Kruse, Ron O. Dror, Carl-Mikael Suomivuori, Meredith A. Skiba, Robert J. Lefkowitz, Laura M. Wingler, Dean P. Staus, Matthew C. King, Naomi R. Latorraca
Publikováno v:
Biophysical Journal. 118:162a
Biased signaling, in which different ligands that bind to the same G protein-coupled receptor preferentially trigger distinct signaling pathways, holds great promise for the design of safer and more effective drugs. Its structural mechanism remains u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26fb96eebc6dfbd243374eb964d06f80
https://doi.org/10.1016/j.bpj.2019.11.1000
https://doi.org/10.1016/j.bpj.2019.11.1000
Autor:
Cheng Huang, Mark J. Schnitzer, Yanping Zhang, Yiyang Gong, Jin Zhong Li, Stephan Eismann, Benjamin F. Grewe
Genetically encoded voltage indicators (GEVIs) are a promising technology for fluorescence readout of millisecond-scale neuronal dynamics. Previous GEVIs had insufficient signaling speed and dynamic range to resolve action potentials in live animals.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21a2ad23942a8ebdc197a73e03365c17
https://europepmc.org/articles/PMC4904846/
https://europepmc.org/articles/PMC4904846/
Autor:
Robert G. Endres, Stephan Eismann
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 11, Iss 12, p e1004650 (2015)
PLoS Computational Biology, Vol 11, Iss 12, p e1004650 (2015)
The chemotaxis sensory system allows bacteria such as Escherichia coli to swim towards nutrients and away from repellents. The underlying pathway is remarkably sensitive in detecting chemical gradients over a wide range of ambient concentrations. Int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e6f746b0b7d50191111a2551376442f
Publikováno v:
Medical Physics. 42:3676-3676
Purpose: Tissue damage prognoses in radiotherapy are based on clonogenic assays that provide dose dependent cell survival rates. However, recent work has shown that apart from dose, systemic reactions and cell-cell communication crucially influence t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::643071ea20fdc0471808d4c9bae68e6c
https://doi.org/10.1118/1.4925987
https://doi.org/10.1118/1.4925987