Zobrazeno 1 - 10
of 143
pro vyhledávání: '"Stephan E, Lehnart"'
Autor:
Matthias Dewenter, Tilmann Seitz, Julia H. Steinbrecher, B. Daan Westenbrink, Haiyun Ling, Stephan E. Lehnart, Xander H.T. Wehrens, Johannes Backs, Joan Heller Brown, Lars S. Maier, Stefan Neef
Publikováno v:
ESC Heart Failure, Vol 11, Iss 4, Pp 2191-2199 (2024)
Abstract Aims Hyperactivity of Ca2+/calmodulin‐dependent protein kinase II (CaMKII) has emerged as a central cause of pathologic remodelling in heart failure. It has been suggested that CaMKII‐induced hyperphosphorylation of the ryanodine recepto
Externí odkaz:
https://doaj.org/article/811ff42f2bd046b0b243e4d8ccb5b35b
Autor:
Niko Schwenzer, Nikolas K. Teiwes, Tobias Kohl, Celine Pohl, Michelle J. Giller, Stephan E. Lehnart, Claudia Steinem
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract A key player of excitable cells in the heart and brain is the L-type calcium channel CaV1.3. In the heart, it is required for voltage-dependent Ca2+-signaling, i.e., for controlling and modulating atrial cardiomyocyte excitation-contraction
Externí odkaz:
https://doaj.org/article/ec223b14c87f493a836e05efc66d3bbf
Autor:
Hugo Amedei, Niels Benjamin Paul, Brian Foo, Lisa Neuenroth, Stephan E. Lehnart, Henning Urlaub, Christof Lenz
Publikováno v:
Frontiers in Analytical Science, Vol 4 (2024)
IntroductionCo-fractionation mass spectrometry couples native-like separations of protein-protein complexes with mass spectrometric proteome analysis for global characterization of protein networks. The technique allows for both de novo detection of
Externí odkaz:
https://doaj.org/article/2aede4e5fb4049c2903bdce2b375d161
Autor:
Gunnar Weninger, Tatiana Pochechueva, Dana El Chami, Xiaojing Luo, Tobias Kohl, Sören Brandenburg, Henning Urlaub, Kaomei Guan, Christof Lenz, Stephan E. Lehnart
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Calpains are calcium-activated neutral proteases involved in the regulation of key signaling pathways. Junctophilin-2 (JP2) is a Calpain-specific proteolytic target and essential structural protein inside Ca2+ release units required for exci
Externí odkaz:
https://doaj.org/article/4776fbc39c47406b95dc5134504a6b9e
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/87d3145ed07c47faac6aee6c937b34e8
Autor:
Franziska Rudolph, Claudia Fink, Judith Hüttemeister, Marieluise Kirchner, Michael H. Radke, Jacobo Lopez Carballo, Eva Wagner, Tobias Kohl, Stephan E. Lehnart, Philipp Mertins, Michael Gotthardt
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Titin determines the elasticity of the sarcomere and integrates into both the Z-disc and the M-band. Here, the authors generate a BioID mouse to study the titin interactome at the Z-disc region in neonatal and adult heart and skeletal muscle.
Externí odkaz:
https://doaj.org/article/8f93ea653e124b8e83b6b456aadd7c7e
Autor:
Jörg W. Wegener, Ahmed Wagdi, Eva Wagner, Dörthe M. Katschinski, Gerd Hasenfuss, Tobias Bruegmann, Stephan E. Lehnart
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Missense mutations in the cardiac ryanodine receptor type 2 (RyR2) characteristically cause catecholaminergic arrhythmias. Reminiscent of the phenotype in patients, RyR2-R2474S knockin mice develop exercise-induced ventricular tachyarrhythmias. In ca
Externí odkaz:
https://doaj.org/article/710f973264f24e6d879ff31f3f3c4fa1
Autor:
M. Caroline Müllenbroich, Allen Kelly, Corey Acker, Gil Bub, Tobias Bruegmann, Anna Di Bona, Emilia Entcheva, Cecilia Ferrantini, Peter Kohl, Stephan E. Lehnart, Marco Mongillo, Camilla Parmeggiani, Claudia Richter, Philipp Sasse, Tania Zaglia, Leonardo Sacconi, Godfrey L. Smith
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Optical techniques for recording and manipulating cellular electrophysiology have advanced rapidly in just a few decades. These developments allow for the analysis of cardiac cellular dynamics at multiple scales while largely overcoming the drawbacks
Externí odkaz:
https://doaj.org/article/a9e4c73a9f3a472da2cc8abc80c6b389
Autor:
Mani Sadredini, Ravinea Manotheepan, Stephan E. Lehnart, Mark E. Anderson, Ivar Sjaastad, Mathis K. Stokke
Publikováno v:
Physiological Reports, Vol 9, Iss 18, Pp n/a-n/a (2021)
Abstract Catecholaminergic polymorphic ventricular tachycardia type 1 (CPVT1) is an inherited arrhythmogenic disorder caused by missense mutations in the cardiac ryanodine receptors (RyR2), that result in increased β‐adrenoceptor stimulation‐ind
Externí odkaz:
https://doaj.org/article/082bcb50b5ce4db2aa77e9874feeee97
Autor:
Leonard Bergau, Rik Willems, David J. Sprenkeler, Thomas H. Fischer, Panayota Flevari, Gerd Hasenfuß, Dimitrios Katsaras, Aleksandra Kirova, Stephan E. Lehnart, Lars Lüthje, Christian Röver, Joachim Seegers, Samuel Sossalla, Albert Dunnink, Rajevaa Sritharan, Anton E. Tuinenburg, Bert Vandenberk, Marc A. Vos, Sofieke C. Wijers, Tim Friede, Markus Zabel
Publikováno v:
Data in Brief, Vol 21, Iss , Pp 2110-2116 (2018)
This data article features supplementary figures and tables related to the article “Differential Multivariable risk prediction of appropriate shock vs. competing mortality – a prospective cohort study to estimate benefits from implantable cardiov
Externí odkaz:
https://doaj.org/article/9918dc415278414a87eaa3a122004b1a