Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Stephan De Waard"'
Autor:
Ludivine Lopez, Stephan De Waard, Hervé Meudal, Cécile Caumes, Kuldip Khakh, Steve Peigneur, Barbara Oliveira-Mendes, Sophia Lin, Jolien De Waele, Jérôme Montnach, Sandrine Cestèle, Agnès Tessier, J.P. Johnson, Massimo Mantegazza, Jan Tytgat, Charles Cohen, Rémy Béroud, Frank Bosmans, Céline Landon, Michel De Waard
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 165, Iss , Pp 115173- (2023)
Nav1.1 is an important pharmacological target as this voltage-gated sodium channel is involved in neurological and cardiac syndromes. Channel activators are actively sought to try to compensate for haploinsufficiency in several of these pathologies.
Externí odkaz:
https://doaj.org/article/00c037522f374110a6181eefd130b12d
Autor:
Perrine Delers, Delphine Sapaly, Badih Salman, Stephan De Waard, Michel De Waard, Suzie Lefebvre
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)
Abstract SMN protein deficiency causes motoneuron disease spinal muscular atrophy (SMA). SMN-based therapies improve patient motor symptoms to variable degrees. An early hallmark of SMA is the perturbation of the neuromuscular junction (NMJ), a synap
Externí odkaz:
https://doaj.org/article/c2b81653e55542179ee659fef4c36a91
Autor:
Bastien Cimarosti, Robin Canac, Stephan De Waard, Aurore Girardeau, Anne Gaignerie, Aude Derevier, Virginie Forest, Michel Ronjat, Hervé Le Marec, Jean-Baptiste Gourraud, Patricia Lemarchand, Michel De Waard, Guillaume Lamirault, Nathalie Gaborit
Publikováno v:
Stem Cell Research, Vol 60, Iss , Pp 102688- (2022)
Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) is an exercise and emotional stress-induced life-threatening inherited heart rhythm disorder, characterized by an abnormal cellular calcium homeostasis. Most reported cases have been linked
Externí odkaz:
https://doaj.org/article/480ef971c3f441c0b9fa5c25d89e4e0e
Autor:
Quentin Coquerel, Claire Legendre, Jacinthe Frangieh, Stephan De Waard, Jérôme Montnach, Leos Cmarko, Joseph Khoury, Charifat Said Hassane, Dimitri Bréard, Benjamin Siegler, Ziad Fajloun, Harold De Pomyers, Kamel Mabrouk, Norbert Weiss, Daniel Henrion, Pascal Richomme, César Mattei, Michel De Waard, Anne-Marie Le Ray, Christian Legros
Publikováno v:
Molecules, Vol 27, Iss 13, p 4133 (2022)
Voltage-gated Na+ (NaV) channels are significant therapeutic targets for the treatment of cardiac and neurological disorders, thus promoting the search for novel NaV channel ligands. With the objective of discovering new blockers of NaV channel ligan
Externí odkaz:
https://doaj.org/article/3c3824003c5c472796fb3122b1c94452
Autor:
Stephan De Waard, Jérôme Montnach, Barbara Ribeiro, Sébastien Nicolas, Virginie Forest, Flavien Charpentier, Matteo Elia Mangoni, Nathalie Gaborit, Michel Ronjat, Gildas Loussouarn, Patricia Lemarchand, Michel De Waard
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 19, p 7167 (2020)
IKr current, a major component of cardiac repolarization, is mediated by human Ether-à-go-go-Related Gene (hERG, Kv11.1) potassium channels. The blockage of these channels by pharmacological compounds is associated to drug-induced long QT syndrome (
Externí odkaz:
https://doaj.org/article/b3ec3b5805764acbb4a48b6a832c655f
Autor:
Sébastien Nicolas, Claude Zoukimian, Frank Bosmans, Jérôme Montnach, Sylvie Diochot, Eva Cuypers, Stephan De Waard, Rémy Béroud, Dietrich Mebs, David Craik, Didier Boturyn, Michel Lazdunski, Jan Tytgat, Michel De Waard
Publikováno v:
Toxins, Vol 11, Iss 6, p 367 (2019)
Phlotoxin-1 (PhlTx1) is a peptide previously identified in tarantula venom (Phlogius species) that belongs to the inhibitory cysteine-knot (ICK) toxin family. Like many ICK-based spider toxins, the synthesis of PhlTx1 appears particularly challenging
Externí odkaz:
https://doaj.org/article/e86d22f9474449df85156f8c0d4cf8f5
Autor:
Jérôme Montnach, Hugo Millet, Antoine Persello, Hervé Meudal, Stephan De Waard, Pietro Mesrica, Barbara Ribeiro, Jérémie Richard, Agnès Hivonnait, Agnès Tessier, Benjamin Lauzier, Flavien Charpentier, Matteo E. Mangoni, Céline Landon, Chris Jopling, Michel De Waard
RATIONALECardiac rhythm, conduction and synchronization of electrical activity require the coordinated action of different types of ion channels that differ according to transmural and regional specificities. Classical pharmacology affects these ion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::036527a695c4da772fea17a8012bb815
https://doi.org/10.1101/2023.03.23.534038
https://doi.org/10.1101/2023.03.23.534038
Autor:
Claude Zoukimian, Jérôme Montnach, Patrick Delmas, Nancy Osorio, Michel De Waard, Céline Marionneau, Sophie Burel, Massimo Mantegazza, Rachid Boukaiba, Sébastien Nicolas, Rémy Béroud, Michel Partiseti, Stephan De Waard
Publikováno v:
British Journal of Pharmacology
British Journal of Pharmacology, 2021, 178 (13), pp.2632-2650. ⟨10.1111/bph.15453⟩
British Journal of Pharmacology, Wiley, 2021, 178 (13), pp.2632-2650. ⟨10.1111/bph.15453⟩
British Journal of Pharmacology, 2021, 178 (13), pp.2632-2650. ⟨10.1111/bph.15453⟩
British Journal of Pharmacology, Wiley, 2021, 178 (13), pp.2632-2650. ⟨10.1111/bph.15453⟩
Background and purpose Protoxin II (ProTx II) is a high affinity gating modifier that is thought to selectively block the Nav 1.7 voltage-dependent Na+ channel, a major therapeutic target for the control of pain. We aimed at producing ProTx II analog
Autor:
Bastien Cimarosti, Robin Canac, Stephan De Waard, Aurore Girardeau, Anne Gaignerie, Aude Derevier, Virginie Forest, Michel Ronjat, Hervé Le Marec, Jean-Baptiste Gourraud, Patricia Lemarchand, Michel De Waard, Guillaume Lamirault, Nathalie Gaborit
Publikováno v:
Stem Cell Research, Vol 60, Iss, Pp 102688-(2022)
Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) is an exercise and emotional stress-induced life-threatening inherited heart rhythm disorder, characterized by an abnormal cellular calcium homeostasis. Most reported cases have been linked
Autor:
Isabelle, Bidaud, Antony Chung You, Chong, Agnes, Carcouet, Stephan De, Waard, Flavien, Charpentier, Michel, Ronjat, Michel De, Waard, Dirk, Isbrandt, Kevin, Wickman, Anne, Vincent, Matteo E, Mangoni, Pietro, Mesirca
Publikováno v:
Scientific Reports
Sinus node (SAN) dysfunction (SND) manifests as low heart rate (HR) and is often accompanied by atrial tachycardia or atrioventricular (AV) block. The only currently available therapy for chronic SND is the implantation of an electronic pacemaker. Be