Supplementary Figures 1-3, Tables 1-3 from LSD1 Inhibition Attenuates Tumor Growth by Disrupting PLK1 Mitotic Pathway

Autor: Margarete Odenthal, Sebastian Klein, Reinhard Buettner, Stephan C. Schaefer, Hannah Eischeid-Scholz, Marion Müller, Sonja Meemboor, So-Young Lim, Iris F. Macheleidt, Priya S. Dalvi

S1: LSD1 inhibition reduces cell viability and migration capacities. S2: Multivariate analysis shows no significant expression differences for the studied genes in between untreated A549 and cisplatin treated A549 cells. S3: IHC staining shows coloca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25f80971f1d7bb940c0ffab8078289c1
https://doi.org/10.1158/1541-7786.22512906.v1

LSD1 Inhibition Attenuates Tumor Growth by Disrupting PLK1 Mitotic Pathway

Autor: Stephan C. Schaefer, Iris Macheleidt, Soyoung Lim, Marion Müller, Sebastian Klein, Margarete Odenthal, Priya Dalvi, Sonja Meemboor, Hannah Eischeid-Scholz, Reinhard Buettner

Publikováno v: Molecular Cancer Research. 17:1326-1337

Lysine-specific demethylase 1 (LSD1) is a histone modifier that is highly overexpressed in lung adenocarcinoma, which results in aggressive tumor biology. Tumor cell proliferation and migration analysis after LSD1 inhibition in the lung adenocarcinom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0f56084df8e810a95495eef5c3eb1b2
https://doi.org/10.1158/1541-7786.mcr-18-0971

What was I thinking? Eye-tracking experiments underscore the bias that architecture exerts on nuclear grading in prostate cancer.

Autor: Dario Bombari, Braulio Mora, Stephan C Schaefer, Fred W Mast, Hans-Anton Lehr

Publikováno v: PLoS ONE, Vol 7, Iss 5, p e38023 (2012)

We previously reported that nuclear grade assignment of prostate carcinomas is subject to a cognitive bias induced by the tumor architecture. Here, we asked whether this bias is mediated by the non-conscious selection of nuclei that "match the expect

Externí odkaz: https://doaj.org/article/30644182c74640298ed46900d77c7c19

Evolution analysis of heterogeneous non-small cell lung carcinoma by ultra-deep sequencing of the mitochondrial genome

Autor: Alexander Adam, Stephan C. Schaefer, Jeannine Meinrath, Hannah Eischeid, Jia Huang, Wafa Amer, Reinhard Buettner, Ulrike Koitzsch, Margarete Odenthal, Erik Vassella, Andreas H. Scheel, Anne Arens, Csaba D. Tóth

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Scientific Reports
Amer, Wafa; Toth, Csaba; Vassella, Erik; Meinrath, Jeannine; Koitzsch, Ulrike; Arens, Anne; Huang, Jia; Eischeid, Hannah; Adam, Alexander; Buettner, Reinhard; Scheel, Andreas; Schaefer, Stephan C; Odenthal, Margarete (2017). Evolution analysis of heterogeneous non-small cell lung carcinoma by ultra-deep sequencing of the mitochondrial genome. Scientific Reports, 7(1), p. 11069. Nature Publishing Group 10.1038/s41598-017-11345-3

Accurate assessment of tumour heterogeneity is an important issue that influences prognosis and therapeutic decision in molecular pathology. Due to the shortage of protective histones and a limited DNA repair capacity, the mitochondrial (mt)-genome u

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http://link.springer.com/article/10.1038/s41598-017-11345-3

Outcome in neonates with necrotizing enterocolitis and patent ductus arteriosus

Autor: Franzisca Schulte, Steffen Berger, Ulf Kessler, Dietmar Cholewa, Mathias Nelle, Peter Michael Klimek, Stephan C Schaefer

Publikováno v: Kessler, Ulf; Schulte, Franzisca; Cholewa, Dietmar; Nelle, Mathias; Schaefer, Stephan C; Klimek, Peter Michael; Berger, Steffen Michael (2016). Outcome in neonates with necrotizing enterocolitis and patent ductus arteriosus. World journal of pediatrics WJP, 12(1), pp. 55-59. Institute of Pediatrics 10.1007/s12519-015-0059-6

BACKGROUND There is no agreement of the influence of patent ductus arteriosus (PDA) on outcomes in patients with necrotizing enterocolitis (NEC). In this study, we assessed the influence of PDA on NEC outcomes. METHODS A retrospective study of 131 in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dac1e35f23d09eb2e5157f9a419c2922