Zobrazeno 1 - 10
of 9 837
pro vyhledávání: '"Stephan C."'
Autor:
Braden T. Tierney, Jonathan Foox, Krista A. Ryon, Daniel Butler, Namita Damle, Benjamin G. Young, Christopher Mozsary, Kristina M. Babler, Xue Yin, Yamina Carattini, David Andrews, Alexander G. Lucaci, Natasha Schaefer Solle, Naresh Kumar, Bhavarth Shukla, Dušica Vidović, Benjamin Currall, Sion L. Williams, Stephan C. Schürer, Mario Stevenson, Ayaaz Amirali, Cynthia Campos Beaver, Erin Kobetz, Melinda M. Boone, Brian Reding, Jennifer Laine, Samuel Comerford, Walter E. Lamar, John J. Tallon, Jeremy Wain Hirschberg, Jacqueline Proszynski, Gabriel Al Ghalith, Kübra Can Kurt, Mark E. Sharkey, George M. Church, George S. Grills, Helena M. Solo-Gabriele, Christopher E. Mason
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Wastewater is a geospatially- and temporally-linked microbial fingerprint of a given population, making it a potentially valuable tool for tracking public health across locales and time. Here, we integrate targeted and bulk RNA sequencing (N
Externí odkaz:
https://doaj.org/article/e0c84d08c6104aac859de15f2159b913
Autor:
Jens Hansen, Yuguang Xiong, Mustafa M. Siddiq, Priyanka Dhanan, Bin Hu, Bhavana Shewale, Arjun S. Yadaw, Gomathi Jayaraman, Rosa E. Tolentino, Yibang Chen, Pedro Martinez, Kristin G. Beaumont, Robert Sebra, Dusica Vidovic, Stephan C. Schürer, Joseph Goldfarb, James M. Gallo, Marc R. Birtwistle, Eric A. Sobie, Evren U. Azeloglu, Seth I. Berger, Angel Chan, Christoph Schaniel, Nicole C. Dubois, Ravi Iyengar
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Drug-induced gene expression profiles can identify potential mechanisms of toxicity. We focus on obtaining signatures for cardiotoxicity of FDA-approved tyrosine kinase inhibitors (TKIs) in human induced-pluripotent-stem-cell-derived cardiom
Externí odkaz:
https://doaj.org/article/5c705931ae3749d8b0d5c464d5e8d788
Publikováno v:
JACS Au, Vol 4, Iss 6, Pp 2068-2080 (2024)
Externí odkaz:
https://doaj.org/article/f8d04bdd57a84dcf9032a078cbb93275
Autor:
Stephanie Niklaus, Stella M. K. Glasauer, Peter Kovermann, Kulsum F. Farshori, Lucia Cadetti, Simon Früh, Nicolas N. Rieser, Matthias Gesemann, Jingjing Zang, Christoph Fahlke, Stephan C. F. Neuhauss
Publikováno v:
Open Biology, Vol 14, Iss 7 (2024)
In the central nervous system of vertebrates, glutamate serves as the primary excitatory neurotransmitter. However, in the retina, glutamate released from photoreceptors causes hyperpolarization in post-synaptic ON-bipolar cells through a glutamate-g
Externí odkaz:
https://doaj.org/article/865a9d9b0c7d4231b313d2574304693f
Autor:
Vincent T. Metzger, Daniel C. Cannon, Jeremy J. Yang, Stephen L. Mathias, Cristian G. Bologa, Anna Waller, Stephan C. Schürer, Dušica Vidović, Keith J. Kelleher, Timothy K. Sheils, Lars Juhl Jensen, Christophe G. Lambert, Tudor I. Oprea, Jeremy S. Edwards
Publikováno v:
PeerJ, Vol 12, p e17470 (2024)
TIN-X (Target Importance and Novelty eXplorer) is an interactive visualization tool for illuminating associations between diseases and potential drug targets and is publicly available at newdrugtargets.org. TIN-X uses natural language processing to i
Externí odkaz:
https://doaj.org/article/960d5f8e591045c1b0baec822e03ab67
Autor:
Perrine F. Kretz, Christel Wagner, Anna Mikhaleva, Charlotte Montillot, Sylvain Hugel, Ilaria Morella, Meghna Kannan, Marie-Christine Fischer, Maxence Milhau, Ipek Yalcin, Riccardo Brambilla, Mohammed Selloum, Yann Herault, Alexandre Reymond, Stephan C. Collins, Binnaz Yalcin
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-22 (2023)
Abstract Background Using mouse genetic studies and systematic assessments of brain neuroanatomical phenotypes, we set out to identify which of the 30 genes causes brain defects at the autism-associated 16p11.2 locus. Results We show that multiple ge
Externí odkaz:
https://doaj.org/article/37637093eaea40888cb9b6562d451f96
Publikováno v:
Geochemistry, Geophysics, Geosystems, Vol 25, Iss 4, Pp n/a-n/a (2024)
Abstract Seismic tomography of Earth's mantle images abundant slab remnants, often located in close proximity to active subduction systems. The impact of such remnants on the dynamics of subduction remains underexplored. Here, we use simulations of m
Externí odkaz:
https://doaj.org/article/5d2f70d4e9f34fdc9480a5c4892a8fce
Autor:
Giulia Diluvio, Tanya T. Kelley, Mohini Lahiry, Annamil Alvarez-Trotta, Ellen M. Kolb, Elena Shersher, Luisana Astudillo, Rhett A. Kovall, Stephan C. Schürer, Anthony J. Capobianco
Publikováno v:
Molecular Therapy: Oncolytics, Vol 28, Iss , Pp 307-320 (2023)
Notch activation complex kinase (NACK) is a component of the Notch transcriptional machinery critical for the Notch-mediated tumorigenesis. However, the mechanism through which NACK regulates Notch-mediated transcription is not well understood. Here,
Externí odkaz:
https://doaj.org/article/b1e16d1d943d4b45b5719482002cf0ad
Autor:
Hie Lim Kim, Tanghua Li, Namrata Kalsi, Hung Tran The Nguyen, Timothy A. Shaw, Khai C. Ang, Keith C. Cheng, Aakrosh Ratan, W. Richard Peltier, Dhrubajyoti Samanta, Mahesh Pratapneni, Stephan C. Schuster, Benjamin P. Horton
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-10 (2023)
Population genomic analyses and palaeogeographical modelling combine to help infer the ancient migration of humans into South Asia from Sundaland, driven by rapid sea level rises.
Externí odkaz:
https://doaj.org/article/9119fe3155504c2d93d8ad7ebaf31487
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 5, p 2538 (2024)
Deep learning is a machine learning technique to model high-level abstractions in data by utilizing a graph composed of multiple processing layers that experience various linear and non-linear transformations. This technique has been shown to perform
Externí odkaz:
https://doaj.org/article/925ab5b1d2ef41f1891e79a342fe000a