Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Stephan Buchmann"'
Autor:
Amélie Le Bihan, Ruben de Kanter, Iñigo Angulo-Barturen, Christoph Binkert, Christoph Boss, Reto Brun, Ralf Brunner, Stephan Buchmann, Jeremy Burrows, Koen J Dechering, Michael Delves, Sonja Ewerling, Santiago Ferrer, Christoph Fischli, Francisco Javier Gamo-Benito, Nina F Gnädig, Bibia Heidmann, María Belén Jiménez-Díaz, Didier Leroy, Maria Santos Martínez, Solange Meyer, Joerg J Moehrle, Caroline L Ng, Rintis Noviyanti, Andrea Ruecker, Laura María Sanz, Robert W Sauerwein, Christian Scheurer, Sarah Schleiferboeck, Robert Sinden, Christopher Snyder, Judith Straimer, Grennady Wirjanata, Jutta Marfurt, Ric N Price, Thomas Weller, Walter Fischli, David A Fidock, Martine Clozel, Sergio Wittlin
Publikováno v:
PLoS Medicine, Vol 13, Iss 10, p e1002138 (2016)
BackgroundArtemisinin resistance observed in Southeast Asia threatens the continued use of artemisinin-based combination therapy in endemic countries. Additionally, the diversity of chemical mode of action in the global portfolio of marketed antimala
Externí odkaz:
https://doaj.org/article/c760742987d34859b710bc8b89e29d3c
Autor:
Alexander Treiber, Stephan Buchmann, Jérôme Segrestaa, Stephane Delahaye, Christopher Kohl, Patricia N. Sidharta, Ruben de Kanter, Carmela Gnerre
Publikováno v:
Clinical Pharmacokinetics. 55:369-380
Macitentan is a novel dual endothelin receptor antagonist for the treatment of pulmonary arterial hypertension (PAH). It is metabolized by cytochrome P450 (CYP) enzymes, mainly CYP3A4, to its active metabolite ACT-132577. A physiological-based pharma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::669f53028d4dc15d96cd127676fa208d
https://doi.org/10.1007/s40262-015-0322-y
https://doi.org/10.1007/s40262-015-0322-y
Autor:
Thomas Weller, Jeremy N. Burrows, David A. Fidock, Sergio Wittlin, Rintis Noviyanti, Robert W. Sauerwein, Grennady Wirjanata, Robert E. Sinden, María Santos Martínez, Christoph Binkert, Christopher Snyder, Nina F. Gnädig, Stephan Buchmann, Ruben de Kanter, Andrea Ruecker, Christoph Fischli, Michael J. Delves, Joerg J. Moehrle, Iñigo Angulo-Barturen, Koen J. Dechering, Christian Scheurer, Francisco Javier Gamo Benito, Solange Meyer, Laura M. Sanz, Christoph Boss, Sarah Schleiferboeck, Martine Clozel, Sonja Ewerling, Caroline L. Ng, Reto Brun, María Belén Jiménez-Díaz, Didier Leroy, Jutta Marfurt, Santiago Ferrer, Walter Fischli, Amélie Le Bihan, Judith Straimer, Bibia Heidmann, Ric N. Price, Ralf Brunner
Publikováno v:
Plos Medicine, 13, e1002138
Plos Medicine, 13, 10, pp. e1002138
PLoS Medicine
PLoS Medicine, Vol 13, Iss 10, p e1002138 (2016)
Plos Medicine, 13, 10, pp. e1002138
PLoS Medicine
PLoS Medicine, Vol 13, Iss 10, p e1002138 (2016)
Background Artemisinin resistance observed in Southeast Asia threatens the continued use of artemisinin-based combination therapy in endemic countries. Additionally, the diversity of chemical mode of action in the global portfolio of marketed antimal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b81f5d3e85fe3cd56c12d27168761c39
https://edoc.unibas.ch/44422/
https://edoc.unibas.ch/44422/
Autor:
Marc Iglarz, Josiane Rein, Solange Meyer, Martine Clozel, Daniel Bur, Thomas Weller, Stephan Buchmann, Martin Bolli, Markus Rey, Christoph Binkert, Patrick Hess, Alexander Treiber, Walter Fischli, Christoph Boss
Publikováno v:
Journal of Medicinal Chemistry. 55:7849-7861
Starting from the structure of bosentan (1), we embarked on a medicinal chemistry program aiming at the identification of novel potent dual endothelin receptor antagonists with high oral efficacy. This led to the discovery of a novel series of alkyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed5b10f0acf9f0af1f400bdecfcbda32
https://doi.org/10.1021/jm3009103
https://doi.org/10.1021/jm3009103
Autor:
Patrick Hess, Gunther Schmidt, Katalin Menyhart, Daniel S. Strasser, Alexander Treiber, Claus Müller, Beat Steiner, Daniel Bur, Christopher Kohl, Roberto Bravo, Christoph Binkert, John Gatfield, Stephan Buchmann, Michael Scherz, Boris Mathys, Virginie Sippel, Stefan Abele, Martin Bolli, Oliver Nayler, Thomas Weller, Céline Mangold
Publikováno v:
Journal of Medicinal Chemistry. 53:4198-4211
Sphingosine-1-phosphate (S1P) is a widespread lysophospholipid which displays a wealth of biological effects. Extracellular S1P conveys its activity through five specific G-protein coupled receptors numbered S1P(1) through S1P(5). Agonists of the S1P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::888f9c30b8d930c09dc96515275dfc76
https://doi.org/10.1021/jm100181s
https://doi.org/10.1021/jm100181s
Autor:
Bruno Capeleto, Keith Morrison, Thomas Weller, Marc Iglarz, Changbin Qiu, Christoph Boss, Alexander Treiber, Walter Fischli, Martin Bolli, Christoph Binkert, Patrick Hess, Stephan Buchmann, John Gatfield, Martine Clozel
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 327:736-745
Macitentan, also called Actelion-1 or ACT-064992 [N-[5-(4-bromophenyl)-6-(2-(5-bromopyrimidin-2-yloxy)ethoxy)-pyrimidin-4-yl]-N'-propylaminosulfonamide], is a new dual ET(A)/ET(B) endothelin (ET) receptor antagonist designed for tissue targeting. Sel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::743d04b2a091c2fdebfdd7df5b3dc3b4
https://doi.org/10.1124/jpet.108.142976
https://doi.org/10.1124/jpet.108.142976
Autor:
Thomas Weller, Hamed Aissaoui, Francois Jenck, Patrick Hess, Susan Flores, Ralf Koberstein, Petra Hoever, Catherine Brisbare-Roch, Jasper Dingemanse, Michael Scherz, Joop M. A. van Gerven, Oliver Nayler, Sanne de Haas, Stephan Buchmann, Walter Fischli, Martine Clozel, Changbin Qiu, Celia Mueller
Publikováno v:
Nature Medicine. 13:150-155
Orexins are hypothalamic peptides that play an important role in maintaining wakefulness in mammals. Permanent deficit in orexinergic function is a pathophysiological hallmark of rodent, canine and human narcolepsy. Here we report that in rats, dogs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58d0f77b48bbd6b76562acdaba22e991
https://doi.org/10.1038/nm1544
https://doi.org/10.1038/nm1544
Autor:
Stephan Buchmann
Publikováno v:
Handbook of Cosmetic Science and Technology ISBN: 9780429135231
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08dac26d99d95add404ca715b31a7bbf
https://doi.org/10.1201/b14400-11
https://doi.org/10.1201/b14400-11
Autor:
Thomas Weller, Martin Bolli, Martine Clozel, Keith Morrison, Alexander Treiber, Judith Marfurt, Stephan Buchmann, Daniel Bur, Christoph Boss, Christoph Binkert, Patrick Hess, Eric Thorin, Walter Fischli, Henri Ramuz, Corinna Grisostomi
Publikováno v:
Journal of medicinal chemistry. 47(11)
Since its discovery in 1988 by Yanagisawa et al., endothelin (ET), a potent vasoconstrictor, has been widely implicated in the pathophysiology of cardiovascular, cerebrovascular, and renal diseases. Many research groups have embarked on the discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5dcff2ab7f8dafea869c200016989b5
https://pubmed.ncbi.nlm.nih.gov/15139756
https://pubmed.ncbi.nlm.nih.gov/15139756