[ 18 F]TRACK, a PET tracer for imaging of tropomyosin receptor kinases (Trk): efficient radiosynthesis and preliminary evaluation in the TgF344‐AD rat model of Alzheimer’s disease

Autor: Min Su Kang, Alexander Thiel, Ralf Schirrmacher, Vadim Bernard‐Gauthier, Carolin Jaworski, Andreas Dorian, Robert Hopewell, Thomas A Singleton, Stephan Blinder, Jean‐Paul Soucy, Pedro Rosa‐Neto, Alexey Kostikov

Publikováno v: Alzheimer's & Dementia. 18

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1181c3e408c44ac6d5ce717ca65f4d2f
https://doi.org/10.1002/alz.064741

Extended treatment with glial cell line-derived neurotrophic factor in Parkinson's Disease

Autor: Mihaela Boca, Robert B. Harrison, Chris Boiko, Max Woolley, Suk Kinch, David W. Johnson, Matthias Luz, Steven S Gill, Erich Mohr, Neil U Barua, Greg A. Johnson, David Cronin, H. Christian Fibiger, Gemma Pritchard, A. Jon Stoessl, Owen T. Lewis, Alan L Whone, Andrew D. Lawrence, Michael Howell, C. Irving, Lucy Mooney, C Lynn Barclay, Christopher Marshall, Sonali Dharia, Jack Broadfoot, Paul Skinner, Lara Longpre, Stephan Blinder, Vesna Sossi, Christian Schroers

Publikováno v: Journal of Parkinson's Disease
Whone, A L, Boca, M, Luz, M, Woolley, M, Mooney, L, Dharia, S, Broadfoot, J, Cronin, D, Schroers, C, Barua, N U, Longpre, L, Barclay, C L, Boiko, C, Johnson, G A, Fibiger, H C, Harrison, R, Lewis, O, Pritchard, G, Howell, M, Irving, C, Johnson, D, Kinch, S, Marshall, C, Lawrence, A D, Blinder, S, Sossi, V, Stoessl, A J, Skinner, P, Mohr, E & Gill, S S 2019, ' Extended Treatment with Glial Cell Line-Derived Neurotrophic Factor in Parkinson's Disease ', Journal of Parkinson's Disease, vol. 9, no. 2, pp. 301-313 . https://doi.org/10.3233/JPD-191576

BACKGROUND: Intraputamenal glial cell line-derived neurotrophic factor (GDNF), administered every 4 weeks to patients with moderately advanced Parkinson's disease, did not show significant clinical improvements against placebo at 40 weeks, although i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b091e1f3509da254e4bc378589c5ff6
https://orca.cardiff.ac.uk/id/eprint/121770/1/untitled.pdf

Randomized trial of intermittent intraputamenal glial cell line-derived neurotrophic factor in Parkinson's disease

Autor: Suk Kinch, Steven S Gill, Chris Boiko, Christian Schroers, C. Irving, C Lynn Barclay, David W. Johnson, Neil U Barua, Stephan Blinder, Michael Howell, Sonali Dharia, Lara Longpre, Paul Skinner, Robert B. Harrison, Jack Broadfoot, Erich Mohr, Alan L Whone, Mihaela Boca, A. Jon Stoessl, Owen T. Lewis, Andrew D. Lawrence, Lucy Mooney, Greg A. Johnson, David Cronin, Vesna Sossi, Matthias Luz, Max Woolley, Christopher Marshall, H. Christian Fibiger, Gemma Pritchard

Publikováno v: Whone, A, Luz, M, Boca, M, Woolley, M, Mooney, L, Dharia, S, Broadfoot, J, Cronin, D, Schroers, C, Barua, N U, Longpre, L, Barclay, C L, Boiko, C, Johnson, G A, Fibiger, H C, Harrison, R, Lewis, O, Pritchard, G, Howell, M, Irving, C, Johnson, D, Kinch, S, Marshall, C, Lawrence, A D, Blinder, S, Sossi, V, Stoessl, A J, Skinner, P, Mohr, E & Gill, S S 2019, ' Randomized trial of intermittent intraputamenal glial cell line-derived neurotrophic factor in Parkinson's disease ', Brain, vol. 142, no. 3, pp. 512-525 . https://doi.org/10.1093/brain/awz023
Brain

Trials of GDNF in Parkinson’s disease have yielded inconsistent results. In a randomised controlled trial, Whone et al. administer GDNF using a paradigm designed to optimize delivery to the putamen. [18F]DOPA PET reveals putamen-wide uptake, but GD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6226e493a07ede7db09cf05c8b8daf5
https://research-information.bris.ac.uk/ws/files/196865531/Full_text_PDF_final_published_version_.pdf

Performance Assessment of a Preclinical PET Scanner with Pinhole Collimation by Comparison to a Coincidence-Based Small-Animal PET Scanner

Autor: Marlies C Goorden, Freek J. Beekman, Ruud M. Ramakers, Frans van der Have, Katherine Dinelle, Maryam Shirmohammad, Matthew D. Walker, Vesna Sossi, Stephan Blinder

Publikováno v: Journal of Nuclear Medicine. 55:1368-1374

PET imaging of rodents is increasingly used in preclinical research, but its utility is limited by spatial resolution and signal-to-noise ratio of the images. A recently developed preclinical PET system uses a clustered-pinhole collimator, enabling h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2470b707c2b58472f523c9d95d00553e
https://doi.org/10.2967/jnumed.113.136663

Frame-to-frame image realignment assessment tool for dynamic brain positron emission tomography

Autor: Geoff Topping, Katherine Dinelle, Henry Ngo, Stephan Blinder, Nasim Vafai, Vesna Sossi

Publikováno v: Medical Physics. 38:773-781

Purpose: Subject motion during positron emission tomography(PET)brain scans can reduce image quality and may lead to incorrect biological outcome measures, especially for data acquired with high resolution tomographs. A semiautomatic method for asses

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0d925532d71c3a7b3125b32eb860f662
https://doi.org/10.1118/1.3537289