Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Stephan Bachmann"'
Autor:
Daniele Cartagenova, Stephan Bachmann, Jereon A. van Bokhoven, Kurt Püntener, Marco Ranocchiari
Publikováno v:
CHIMIA, Vol 75, Iss 11, Pp 972-978 (2021)
The synthesis of drug substances (DS) requires the continuous effort of the pharma industry to ensure high sustainability standards. The Suzuki-Miyaura cross coupling is a fundamental C–C bond-forming reaction to produce complex DS intermediates. T
Externí odkaz:
https://doaj.org/article/9ed6e13f80734bb0a04a34bb85b70eab
Autor:
Stephan Bachmann, Hans Iding, Christian Lautz, Isabelle Thomé-Pfeiffer, Caroline Maierhofer, Régis Mondière, Christoph Strasser, Thomas Bär, André Aebi, Andre Schuster, Philipp Schmidt
Publikováno v:
CHIMIA, Vol 75, Iss 7/8, Pp 605-613 (2021)
Ipatasertib is a potent small molecule Akt kinase inhibitor currently being tested in Phase III clinical trials for the treatment of metastatic castration-resistant prostate cancer and triple negative metastatic breast cancer. In this paper an overvi
Externí odkaz:
https://doaj.org/article/670ffc3b70804677822b0735a25d1d8b
Autor:
Jie Xu, Ngiap-Kie Lim, Jacob C. Timmerman, Jeff Shen, Kyle Clagg, Ugo Orcel, Raphael Bigler, Etienne Trachsel, Roland Meier, Nicholas A. White, Johannes A. Burkhard, Lauren E. Sirois, Qingping Tian, Remy Angelaud, Stephan Bachmann, Haiming Zhang, Francis Gosselin
Publikováno v:
Organic Letters. 25:3417-3422
Autor:
Daniele Cartagenova, Stephan Bachmann, Kurt Püntener, Michelangelo Scalone, Mark A. Newton, Fabio A. Peixoto Esteves, Thomas Rohrbach, Patrik P. Zimmermann, Jeroen A. van Bokhoven, Marco Ranocchiari
Publikováno v:
Catalysis Science & Technology. 12:954-961
A phosphine-functionalized MOF was used to prepare molecularly-defined palladium catalysts, active for Suzuki coupling in mild conditions. Their selectivity was correlated with the nature of the catalytic active site via XAS and NMR.
Autor:
Daniel Zell, Andreas Stumpf, Michael E. Dalziel, Eduardo V. Mercado-Marin, Stephan Bachmann, Haiming Zhang, Stefan G. Koenig, Diane E. Carrera, Francis Gosselin
Publikováno v:
Organic Process Research & Development. 25:2338-2350
Autor:
Frédéric St-Jean, Rémy Angelaud, Stephan Bachmann, Diane E. Carrera, Travis Remarchuk, Katarzyna A. Piechowicz, Katrin Niedermann, Hans Iding, Roland Meier, Haiyun Hou, Lauren E. Sirois, Jie Xu, Martin Olbrich, Pankaj Rege, Maud Guillemot-Plass, Francis Gosselin
Publikováno v:
The Journal of organic chemistry. 87(7)
A highly efficient asymmetric synthesis of the IDO inhibitor navoximod, featuring the stereoselective installation of two relative and two absolute stereocenters from an advanced racemic intermediate, is described. The stereocenters were set via a cr
Autor:
Muhammad Anwar, Hanan Atia, Matthias Beller, Dario Formenti, Kathrin Junge, Sarim Dastgir, Rita Mocci, Michelangelo Scalone, Stephan Bachmann
Publikováno v:
Chemistry – A European Journal. 26:15589-15595
Cobalt-doped hybrid materials consisting of metal oxides and carbon derived from chitin were prepared, characterized and tested for industrially relevant nitrile hydrogenations. The optimal catalyst supported onto MgO showed, after pyrolysis at 700
Autor:
Stefan Hildbrand, Andreas Pfaltz, Francis Gosselin, Stephan Bachmann, Scott E. Denmark, Kyle A. Mack, Jeff Shen, Paolo Tosatti, Haiming Zhang, Michelangelo Scalone, Raphael Bigler, Chong Han
Publikováno v:
Angewandte Chemie International Edition. 59:2844-2849
Asymmetric hydrogenation has evolved as one of the most powerful tools to construct stereocenters. However, the asymmetric hydrogenation of unfunctionalized tetrasubstituted acyclic olefins remains the pinnacle of asymmetric synthesis and an unsolved
Autor:
Stephan Bachmann, Anke Spannenberg, Michelangelo Scalone, Helen Hornke, Kathrin Junge, Svenja Budweg, Zhihong Wei, Haijun Jiao, Matthias Beller, Garbe Marcel, Veronica Papa
Publikováno v:
Catalysis Science & Technology. 10:3994-4001
A general manganese catalyzed chemoselective semihydrogenation of alkynes to olefins in the presence of molecular hydrogen is described. The best results are obtained by applying the aliphatic Mn PNP pincer complex Mn-3c which allows the transformati
Autor:
Paolo Tosatti, Stephan Bachmann, C. Oliver Kappe, Kurt Püntener, Joerg Sedelmeier, Jason D. Williams, René Lebl
Catalytic static mixer (CSM) technology is presented as an industrially-viable solution for an aromatic nitro group reduction in the synthesis of fenebrutinib. Factors effecting catalyst inhibition could be rapidly understood and mitigated by the use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34b53de3a4a0f599ccd9574d8ed45a1b
https://doi.org/10.26434/chemrxiv-2021-xcxcr
https://doi.org/10.26434/chemrxiv-2021-xcxcr