Zobrazeno 1 - 10
of 252
pro vyhledávání: '"Stephan A Sieber"'
Autor:
Timo Risch, Dominik Kolling, Dietrich Mostert, Tim Seedorf, Dominik Heimann, Daniel Kohnhäuser, Felix Deschner, Franziska Fries, Danny Solga, Jil-Sophie Hilgers, Jan Dastbaz, Stefano Mancini, Anna K. H. Hirsch, Mark Brönstrup, Andreas Kirschning, Stephan A. Sieber, Jennifer Herrmann, Rolf Müller
Publikováno v:
npj Antimicrobials and Resistance, Vol 2, Iss 1, Pp 1-12 (2024)
Abstract Antimicrobial resistance is one of the major health threats of the modern world. Thus, new structural classes of antimicrobial compounds are needed in order to overcome existing resistance. Cystobactamids represent one such new compound clas
Externí odkaz:
https://doaj.org/article/d82bddf7ab0144049f713a0e4128ea79
Autor:
Eleonora Diamanti, Annina M. Steinbach, Lais P. de Carvalho, Henni-Karoliina Ropponen, Antoine Lacour, Rawia Hamid, Sidra Eisa, Patricia Bravo, Spyridon Bousis, Boris Illarionov, Markus Fischer, Mostafa M. Hamed, Nina C. Bach, Matthias Rottmann, Jana Held, Matthias Witschel, Stephan A. Sieber, Anna K. H. Hirsch
Publikováno v:
ACS Omega, Vol 9, Iss 44, Pp 44465-44473 (2024)
Externí odkaz:
https://doaj.org/article/1c5fd5c8fb1c4417b109e48562a58aee
Autor:
Dominik Schum, Franziska A. V. Elsen, Stuart Ruddell, Kenji Schorpp, Howard Junca, Mathias Müsken, Shu-Yu Chen, Michaela K. Fiedler, Thomas Pickl, Dietmar H. Pieper, Kamyar Hadian, Martin Zacharias, Stephan A. Sieber
Publikováno v:
JACS Au, Vol 4, Iss 8, Pp 3125-3134 (2024)
Externí odkaz:
https://doaj.org/article/65bd87ac39654709b229c1331699629c
Autor:
Shu-Yu Chen, Michaela K. Fiedler, Thomas F. Gronauer, Olesia Omelko, Marie-Kristin von Wrisberg, Tao Wang, Sabine Schneider, Stephan A. Sieber, Martin Zacharias
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract Staphylococcus aureus signal peptidase IB (SpsB) is an essential enzyme for protein secretion. While inhibition of its activity by small molecules is a well-precedented mechanism to kill bacteria, the mode of activation is however less under
Externí odkaz:
https://doaj.org/article/29fa57a779a04f2d86a49e6cf38e078d
Autor:
Thomas Kirmeier, Ranganath Gopalakrishnan, Vanessa Gormanns, Anna M Werner, Serena Cuboni, Georg C Rudolf, Georg Höfner, Klaus T Wanner, Stephan A Sieber, Ulrike Schmidt, Florian Holsboer, Theo Rein, Felix Hausch
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0148608 (2016)
The aim of this study was to design, synthesize and validate a multifunctional antidepressant probe that is modified at two distinct positions. The purpose of these modifications was to allow covalent linkage of the probe to interaction partners, and
Externí odkaz:
https://doaj.org/article/c7800bb20b1a4b45897b23cc0a2bd9b8
Autor:
Maximilian Hohmann, Valentina Brunner, Widya Johannes, Dominik Schum, Laura M. Carroll, Tianzhe Liu, Daisuke Sasaki, Johanna Bosch, Thomas Clavel, Stephan A. Sieber, Georg Zeller, Markus Tschurtschenthaler, Klaus-Peter Janßen, Tobias A. M. Gulder
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract The gut microbiota influences human health and the development of chronic diseases. However, our understanding of potentially protective or harmful microbe-host interactions at the molecular level is still in its infancy. To gain further ins
Externí odkaz:
https://doaj.org/article/9dfc486a3c544c3f8858b03305338c9f
Autor:
Josef Braun, Yudong Hu, Adrian T. Jauch, Thomas F. Gronauer, Julia Mergner, Nina C. Bach, Franziska R. Traube, Stefan Zahler, Stephan A. Sieber
Publikováno v:
JACS Au, Vol 4, Iss 5, Pp 1833-1840 (2024)
Externí odkaz:
https://doaj.org/article/668d895d9ae64ad2bc0bb39ee04103f1
Publikováno v:
ACS Central Science, Vol 10, Iss 4, Pp 823-832 (2024)
Externí odkaz:
https://doaj.org/article/365a5f1623884cc5b1e73d15d5c14d9c
Autor:
Davide Boldini, Davide Ballabio, Viviana Consonni, Roberto Todeschini, Francesca Grisoni, Stephan A. Sieber
Publikováno v:
Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-16 (2024)
Abstract Natural products are a diverse class of compounds with promising biological properties, such as high potency and excellent selectivity. However, they have different structural motifs than typical drug-like compounds, e.g., a wider range of m
Externí odkaz:
https://doaj.org/article/46f966aabfba49c5aca910c8dd8a61cc
The DNA-binding induced (de)AMPylation activity of a Coxiella burnetii Fic enzyme targets Histone H3
Autor:
Dorothea Höpfner, Adam Cichy, Vivian Pogenberg, Christoph Krisp, Soraya Mezouar, Nina C. Bach, Jan Grotheer, Sandra Madariaga Zarza, Eric Martinez, Matteo Bonazzi, Matthias J. Feige, Stephan A. Sieber, Hartmut Schlüter, Aymelt Itzen
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-25 (2023)
Abstract The intracellular bacterial pathogen Coxiella burnetii evades the host response by secreting effector proteins that aid in establishing a replication-friendly niche. Bacterial filamentation induced by cyclic AMP (Fic) enzymes can act as effe
Externí odkaz:
https://doaj.org/article/14d98f47b7b6442fbdefaf8c5d58cfd3