The helicase DinG responds to stress due to DNA double strand breaks.

Autor: Stephan A Frye, Getachew Tesfaye Beyene, Amine Namouchi, Marta Gómez-Muñoz, Håvard Homberset, Shewit Kalayou, Tahira Riaz, Tone Tønjum, Seetha V Balasingham

Publikováno v: PLoS ONE, Vol 12, Iss 11, p e0187900 (2017)

Neisseria meningitidis (Nm) is a Gram-negative nasopharyngeal commensal that can cause septicaemia and meningitis. The neisserial DNA damage-inducible protein DinG is a helicase related to the mammalian helicases XPD and FANCJ. These helicases belong

Externí odkaz: https://doaj.org/article/c1d52ee2e74647d8b87466474089556e

The Inner Membrane Protein PilG Interacts with DNA and the Secretin PilQ in Transformation.

Autor: Stephan A Frye, Emma Lång, Getachew Tesfaye Beyene, Seetha V Balasingham, Håvard Homberset, Alexander D Rowe, Ole Herman Ambur, Tone Tønjum

Publikováno v: PLoS ONE, Vol 10, Iss 8, p e0134954 (2015)

Expression of type IV pili (Tfp), filamentous appendages emanating from the bacterial surface, is indispensable for efficient neisserial transformation. Tfp pass through the secretin pore consisting of the membrane protein PilQ. PilG is a polytopic m

Externí odkaz: https://doaj.org/article/92f43c8ecd1c4098829952528c28f5f2

Restriction and sequence alterations affect DNA uptake sequence-dependent transformation in Neisseria meningitidis.

Autor: Ole Herman Ambur, Stephan A Frye, Mariann Nilsen, Eirik Hovland, Tone Tønjum

Publikováno v: PLoS ONE, Vol 7, Iss 7, p e39742 (2012)

Transformation is a complex process that involves several interactions from the binding and uptake of naked DNA to homologous recombination. Some actions affect transformation favourably whereas others act to limit it. Here, meticulous manipulation o

Externí odkaz: https://doaj.org/article/a91df29f1c4c4e1dbd7a029b443332b2

AMR-Diag: Neural network based genotype-to-phenotype prediction of resistance towards β-lactams in Escherichia coli and Klebsiella pneumoniae

Autor: Priyanka Sharma, Arne Michael Taxt, Punit Kaur, Kolin Paul, Harpreet Singh, Arti Kapil, Rafi Ahmad, Stephan A. Frye, Ekaterina Avershina, Umaer Naseer

Publikováno v: Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 1896-1906 (2021)

Graphical abstract
Antibiotic resistance poses a major threat to public health. More effective ways of the antibiotic prescription are needed to delay the spread of antibiotic resistance. Employment of sequencing technologies coupled with the us

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0936ea3dccf17b53ce39e28557702e14
https://hdl.handle.net/10037/21609

DprA from Neisseria meningitidis: properties and role in natural competence for transformation

Autor: Ole Herman Ambur, Håvard Homberset, Eirik Hovland, Tone Tønjum, Marta Gómez-Muñoz, Jeremy P. Derrick, Getachew Tesfaye Beyene, Stephan A. Frye, Seetha V. Balasingham

Publikováno v: Microbiology
Hovland, E, Beyene, G T, Frye, S A, Homberset, H, Balasingham, S V, Gómez-Muñoz, M, Derrick, J P, Tønjum, T & Ambur, O H 2017, ' DprA from Neisseria meningitidis : Properties and role in natural competence for transformation ', Microbiology, vol. 163, no. 7, pp. 1016-1029 . https://doi.org/10.1099/mic.0.000489

DNA processing chain A (DprA) is a DNA-binding protein that is ubiquitous in bacteria and expressed in some archaea. DprA is active in many bacterial species that are competent for transformation of DNA, but its role in Neisseriameningitidis (Nm) is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7de033522650227b831d44048ab3de45
https://pubmed.ncbi.nlm.nih.gov/28696187