Zobrazeno 1 - 10
of 250
pro vyhledávání: '"Stephan A, Sieber"'
Autor:
Dominik Schum, Franziska A. V. Elsen, Stuart Ruddell, Kenji Schorpp, Howard Junca, Mathias Müsken, Shu-Yu Chen, Michaela K. Fiedler, Thomas Pickl, Dietmar H. Pieper, Kamyar Hadian, Martin Zacharias, Stephan A. Sieber
Publikováno v:
JACS Au, Vol 4, Iss 8, Pp 3125-3134 (2024)
Externí odkaz:
https://doaj.org/article/65bd87ac39654709b229c1331699629c
Autor:
Shu-Yu Chen, Michaela K. Fiedler, Thomas F. Gronauer, Olesia Omelko, Marie-Kristin von Wrisberg, Tao Wang, Sabine Schneider, Stephan A. Sieber, Martin Zacharias
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract Staphylococcus aureus signal peptidase IB (SpsB) is an essential enzyme for protein secretion. While inhibition of its activity by small molecules is a well-precedented mechanism to kill bacteria, the mode of activation is however less under
Externí odkaz:
https://doaj.org/article/29fa57a779a04f2d86a49e6cf38e078d
Autor:
Maximilian Hohmann, Valentina Brunner, Widya Johannes, Dominik Schum, Laura M. Carroll, Tianzhe Liu, Daisuke Sasaki, Johanna Bosch, Thomas Clavel, Stephan A. Sieber, Georg Zeller, Markus Tschurtschenthaler, Klaus-Peter Janßen, Tobias A. M. Gulder
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract The gut microbiota influences human health and the development of chronic diseases. However, our understanding of potentially protective or harmful microbe-host interactions at the molecular level is still in its infancy. To gain further ins
Externí odkaz:
https://doaj.org/article/9dfc486a3c544c3f8858b03305338c9f
Autor:
Josef Braun, Yudong Hu, Adrian T. Jauch, Thomas F. Gronauer, Julia Mergner, Nina C. Bach, Franziska R. Traube, Stefan Zahler, Stephan A. Sieber
Publikováno v:
JACS Au, Vol 4, Iss 5, Pp 1833-1840 (2024)
Externí odkaz:
https://doaj.org/article/668d895d9ae64ad2bc0bb39ee04103f1
Publikováno v:
ACS Central Science, Vol 10, Iss 4, Pp 823-832 (2024)
Externí odkaz:
https://doaj.org/article/365a5f1623884cc5b1e73d15d5c14d9c
Autor:
Davide Boldini, Davide Ballabio, Viviana Consonni, Roberto Todeschini, Francesca Grisoni, Stephan A. Sieber
Publikováno v:
Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-16 (2024)
Abstract Natural products are a diverse class of compounds with promising biological properties, such as high potency and excellent selectivity. However, they have different structural motifs than typical drug-like compounds, e.g., a wider range of m
Externí odkaz:
https://doaj.org/article/46f966aabfba49c5aca910c8dd8a61cc
The DNA-binding induced (de)AMPylation activity of a Coxiella burnetii Fic enzyme targets Histone H3
Autor:
Dorothea Höpfner, Adam Cichy, Vivian Pogenberg, Christoph Krisp, Soraya Mezouar, Nina C. Bach, Jan Grotheer, Sandra Madariaga Zarza, Eric Martinez, Matteo Bonazzi, Matthias J. Feige, Stephan A. Sieber, Hartmut Schlüter, Aymelt Itzen
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-25 (2023)
Abstract The intracellular bacterial pathogen Coxiella burnetii evades the host response by secreting effector proteins that aid in establishing a replication-friendly niche. Bacterial filamentation induced by cyclic AMP (Fic) enzymes can act as effe
Externí odkaz:
https://doaj.org/article/14d98f47b7b6442fbdefaf8c5d58cfd3
Publikováno v:
Journal of Cheminformatics, Vol 15, Iss 1, Pp 1-13 (2023)
Abstract Decision tree ensembles are among the most robust, high-performing and computationally efficient machine learning approaches for quantitative structure–activity relationship (QSAR) modeling. Among them, gradient boosting has recently garne
Externí odkaz:
https://doaj.org/article/ef3fe130feb445e3a9edaf794e2c3fb1
Publikováno v:
Journal of Cheminformatics, Vol 14, Iss 1, Pp 1-13 (2022)
Abstract While in the last years there has been a dramatic increase in the number of available bioassay datasets, many of them suffer from extremely imbalanced distribution between active and inactive compounds. Thus, there is an urgent need for nove
Externí odkaz:
https://doaj.org/article/149f4f03e4e94059a0f93760bd8cb8a5
Extracellular LGALS3BP regulates neural progenitor position and relates to human cortical complexity
Autor:
Christina Kyrousi, Adam C. O’Neill, Agnieska Brazovskaja, Zhisong He, Pavel Kielkowski, Laure Coquand, Rossella Di Giaimo, Pierpaolo D’ Andrea, Alexander Belka, Andrea Forero Echeverry, Davide Mei, Matteo Lenge, Cristiana Cruceanu, Isabel Y. Buchsbaum, Shahryar Khattak, Guimiot Fabien, Elisabeth Binder, Frances Elmslie, Renzo Guerrini, Alexandre D. Baffet, Stephan A. Sieber, Barbara Treutlein, Stephen P. Robertson, Silvia Cappello
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Basal progenitors are enriched in gyrencephalic species like humans contributing to neuronal expansion. Here the authors show that LGALS3BP de novo variants are related to reduced cortical complexity and area in humans and that LGALS3BP regulates neu
Externí odkaz:
https://doaj.org/article/8ef84fb2a10e47ca9c3467c7a2d8e981