Zobrazeno 1 - 10
of 159
pro vyhledávání: '"Stephan, Scheurer"'
Autor:
Hannah Rainer, Alexandra Goretzki, Yen-Ju Lin, Hannah Ruth Schiller, Maren Krause, Sascha Döring, Daniel Strecker, Ann-Christine Junker, Sonja Wolfheimer, Masako Toda, Stephan Scheurer, Stefan Schülke
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 18, p 9914 (2024)
In allergen-specific immunotherapy, adjuvants are explored for modulating allergen-specific Th2 immune responses to re-establish clinical tolerance. One promising class of adjuvants are β-glucans, which are naturally derived sugar structures and com
Externí odkaz:
https://doaj.org/article/5d085b29799d42bb902822428bb7922b
Autor:
Yen-Ju Lin, Annette Jamin, Sonja Wolfheimer, Anna Fiedler, Ann-Christine Junker, Alexandra Goretzki, Stephan Scheurer, Stefan Schülke
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundA recombinant fusion protein combining the adjuvant and TLR5-ligand flagellin with the major birch pollen allergen Bet v 1 (rFlaA:Betv1) has been suggested to prevent the manifestation of birch allergy. Noteworthy, rFlaA:Betv1 induced both
Externí odkaz:
https://doaj.org/article/7e50bdd9809d4914aa1fc0154a4ea7f2
Autor:
Jennifer Zimmermann, Alexandra Goretzki, Clara Meier, Sonja Wolfheimer, Yen-Ju Lin, Hannah Rainer, Maren Krause, Saskia Wedel, Gerd Spies, Frank Führer, Stefan Vieths, Stephan Scheurer, Stefan Schülke
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundRecently, bacterial components were shown to enhance immune responses by shifting immune cell metabolism towards glycolysis and lactic acid production, also known as the Warburg Effect. Currently, the effect of allergen products for immunot
Externí odkaz:
https://doaj.org/article/587e4ac925034b488b25d9fe6bff272a
Autor:
Maren Krause, Peter Crauwels, Frank Blanco-Pérez, Martin Globisch, Andrea Wangorsch, Thomas Henle, Jonas Lidholm, Ger van Zandbergen, Stefan Vieths, Stephan Scheurer, Masako Toda
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Evidence has suggested that major peanut allergen Ara h 1 activates dendritic cells (DCs) via interaction with DC-SIGN (dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin), a C-type lectin receptor, and contribut
Externí odkaz:
https://doaj.org/article/20c6e2aeda004d45aa57242365d95d6c
Autor:
Andrea Wangorsch, Stephan Scheurer, Miguel Blanca, Natalia Blanca-Lopez, María Luisa Somoza, Laura Martín-Pedraza
Publikováno v:
Frontiers in Allergy, Vol 3 (2022)
Only a small fraction of proteins in plants and animals are classified as allergens. The allergenic properties are frequently attributed to certain functional characteristics of the proteins, such as a role in the plant defense against biotic and abi
Externí odkaz:
https://doaj.org/article/9d3ee169b17c4d1baafe0a20b99040a1
Autor:
Alexandra Goretzki, Yen-Ju Lin, Jennifer Zimmermann, Hannah Rainer, Ann-Christine Junker, Sonja Wolfheimer, Stefan Vieths, Stephan Scheurer, Stefan Schülke
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 20, p 12695 (2022)
Trained immune responses, based on metabolic and epigenetic changes in innate immune cells, are de facto innate immune memory and, therefore, are of great interest in vaccine development. In previous studies, the recombinant fusion protein rFlaA:Betv
Externí odkaz:
https://doaj.org/article/b744997052e34e14a99f2149675407ae
Autor:
Andrea Wangorsch, Annette Jamin, Stephanie Eichhorn, Isabel Pablos, Swati Sharma, Bettina Schweidler, Bianca Kastner, Sabrina Wildner, Joachim Saloga, Frank Führer, Reinaldo Rafael Reyna Orozco, Roya Sherkat, Somayeh Sadeghi, Fardis Teifoori, Jung-Won Park, Peter Briza, Stefan Vieths, Fatima Ferreira, Naveen Arora, Jonas Lidholm, Gabriele Gadermaier, Stephan Scheurer
Publikováno v:
Frontiers in Allergy, Vol 2 (2021)
Background: Manifestation of respiratory allergy to American cockroach (Periplaneta americana) is prominent in the subtropical and tropical areas. However, co-existing perennial indoor inhalant allergies frequently compromise clinical diagnosis of co
Externí odkaz:
https://doaj.org/article/f607cf4b7067471ba120fea7e497b538
Autor:
Yen-Ju Lin, Adam Flaczyk, Sonja Wolfheimer, Alexandra Goretzki, Annette Jamin, Andrea Wangorsch, Stefan Vieths, Stephan Scheurer, Stefan Schülke
Publikováno v:
Cells, Vol 10, Iss 12, p 3415 (2021)
Developing new adjuvants/vaccines and better understanding their mode-of-action is an important task. To specifically improve birch pollen allergy treatment, we designed a fusion protein consisting of major birch pollen allergen Betv1 conjugated to t
Externí odkaz:
https://doaj.org/article/ada92b2bd4b242b78ca3ffc836ea0bb8
Autor:
Hanna Steigerwald, Frank Blanco-Perez, Melanie Albrecht, Caroline Bender, Andrea Wangorsch, Hans-Ulrich Endreß, Mirko Bunzel, Cristobalina Mayorga, Maria José Torres, Stephan Scheurer, Stefan Vieths
Publikováno v:
Foods, Vol 11, Iss 1, p 13 (2021)
Pectin, a dietary fiber, is a polysaccharide that is widely used in food industry as a gelling agent. In addition, prebiotic and beneficial immunomodulatory effects of pectin have been demonstrated, leading to increased importance as food supplement.
Externí odkaz:
https://doaj.org/article/95bbde4de09c4908a90b8a151201054a
Autor:
Alexandra Goretzki, Yen‐Ju Lin, Clara Meier, Britta Dorn, Sonja Wolfheimer, Annette Jamin, Maike Schott, Andrea Wangorsch, Stefan Vieths, Thilo Jakob, Stephan Scheurer, Stefan Schülke
Publikováno v:
Allergy. 78:663-681
The experimental fusion protein rFlaA:Betv1 was shown to efficiently suppress allergen-specific sensitization in mice. However, the detailed mechanism of rFlaA:Betv1-mediated immune modulation is not fully understood. In this study, we investigated t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ff79d3b6d76ab837a769de90d6c6da1
https://doi.org/10.1111/all.15542
https://doi.org/10.1111/all.15542