Zobrazeno 1 - 10 of 13 pro vyhledávání: '"Stephan, Pritz"'
1
Evidence for Extensive Non-Endocytotic Translocation of Peptide Nucleic Acids Across Mammalian Plasma Membranes
Autor: Michael Bienert, Yvonne Turner, Stephan Pritz, Johannes Oehlke
Publikováno v: Current Drug Delivery. 8:526-533
The ability of peptide nucleic acids (PNA) to enter and to cross filter-grown MDCK, HEK and CHO cells was studied by means of a protocol based on capillary electrophoresis combined with laser-induced fluorescence detection. The used approach avoided
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2098f363e3fe3b52bc9864beaf3408fd
https://doi.org/10.2174/156720111796642291
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2
Growth Factor- and Adhesion Protein-Like Components of Fetal Calf Serum Can Significantly Enhance the Intracellular Delivery of Peptide Nucleic Acids
Autor: Burkhard Wiesner, Angelika Ehrlich, Stephan Pritz, Eberhard Krause, Michael Beyermann, Johannes Oehlke
Publikováno v: Nucleic Acid Therapeutics. 21:285-291
Evidence is presented that components of fetal calf serum (FCS) can significantly enhance the splicing correction activity of peptide nucleic acids (PNA) in HeLa pLuc 705 cells. The effect proved more pronounced for PNAs bearing fluorescence tags and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3115c051d7e09ab00eb866cc1d9284f1
https://doi.org/10.1089/nat.2011.0297
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3
A Fluorescence Lifetime-Based Assay for Abelson Kinase
Autor: Gabriele Meder, Klaus Doering, Julian Woelcke, Peter Drueckes, Ulrich Hassiepen, Stephan Pritz, Lorenz M. Mayr
Publikováno v: SLAS Discovery. 16:65-72
We present a novel homogeneous in vitro assay format and apply it to the quantitative determination of the enzymatic activity of a tyrosine kinase. The assay employs a short peptidic substrate containing a single tyrosine and a single probe attached
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::071d6bfc9d34da676c005819a73fc7b5
https://doi.org/10.1177/1087057110385817
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4
Cellular uptake and biological activity of peptide nucleic acids conjugated with peptides with and without cell-penetrating ability
Autor: Burkhard Wiesner, Johannes Oehlke, Yvonne Turner, Stephan Pritz, Gerd Wallukat, Pille Säälik
Publikováno v: Journal of Peptide Science. 16:71-80
A 12-mer peptide nucleic acid (PNA) directed against the nociceptin/orphanin FQ receptor mRNA was disulfide bridged with various peptides without and with cell-penetrating features. The cellular uptake and the antisense activity of these conjugates w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2e7d4aa5bdef19155ff5a3a692c07c82
https://doi.org/10.1002/psc.1198
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6
Synthesis of Biologically Active Peptide Nucleic Acid−Peptide Conjugates by Sortase-Mediated Ligation
Autor: Jana Klose, Oliver Kraetke, Yvonne Wolf, Stephan Pritz, Michael Beyermann, Michael Bienert
Publikováno v: The Journal of Organic Chemistry. 72:3909-3912
Sortase A is a transpeptidase that cleaves at a pentapeptide-motif and subsequently transfers the acyl component to a nucleophile containing N-terminal oligoglycines. We investigate the reaction conditions of the sortase-mediated ligation and demonst
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb52e12130dc8a52b1ebd8a84eb6b1f7
https://doi.org/10.1021/jo062331l
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7
Modification of guanine residues in PNA-synthesis by PyBOP
Autor: Stephan Pritz, Michael Bienert, Clementine Klemm, Yvonne Wolf
Publikováno v: Tetrahedron Letters. 47:5893-5896
The phosphonium-type coupling reagent PyBOP, when applied to the synthesis of peptide nucleic acid (PNA) oligomers, was found to form O 4 -phosphonium compounds of the nucleobase guanine which can be converted into C 4 -modified guanine-derived PNAs
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ca76bf8a0949f0b2f728478bb498b5a
https://doi.org/10.1016/j.tetlet.2006.06.069
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8
Fluorescence lifetime assays: current advances and applications in drug discovery
Autor: Ulrich Hassiepen, Julian Woelcke, Klaus Doering, Stephan Pritz
Publikováno v: Expert opinion on drug discovery. 6(6)
Fluorescence lifetime assays complement the portfolio of established assay formats available in drug discovery, particularly with the recent advances in microplate readers and the commercial availability of novel fluorescent labels. Fluorescence life
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f19ed7b8907e06547eb2a6e4a440824
https://pubmed.ncbi.nlm.nih.gov/22646154
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9
Cellular uptake and biological activity of peptide nucleic acids conjugated with peptides with and without cell-penetrating ability
Autor: Yvonne, Turner, Gerd, Wallukat, Pille, Säälik, Burkhard, Wiesner, Stephan, Pritz, Johannes, Oehlke
Publikováno v: Journal of peptide science : an official publication of the European Peptide Society. 16(1)
A 12-mer peptide nucleic acid (PNA) directed against the nociceptin/orphanin FQ receptor mRNA was disulfide bridged with various peptides without and with cell-penetrating features. The cellular uptake and the antisense activity of these conjugates w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4261a3fb12be4fc7d4abc89512c4f2b4
https://pubmed.ncbi.nlm.nih.gov/19943337
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