Zobrazeno 1 - 10
of 180
pro vyhledávání: '"Stephan, Grzesiek"'
Autor:
Johannes Paladini, Annalena Maier, Judith Maria Habazettl, Ines Hertel, Rajesh Sonti, Stephan Grzesiek
Publikováno v:
eLife, Vol 12 (2024)
Abelson tyrosine kinase (Abl) is regulated by the arrangement of its regulatory core, consisting sequentially of the SH3, SH2, and kinase (KD) domains, where an assembled or disassembled core corresponds to low or high kinase activity, respectively.
Externí odkaz:
https://doaj.org/article/ef746d7d048644ea99ceb28b7e3f3eec
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Signal transmission and regulation of G-protein-coupled receptors (GPCRs) by ligands occurs via modulation of complex conformational equilibria. Here authors quantify these equilibria and their dynamics in the β1-adrenergic receptor in its apo form
Externí odkaz:
https://doaj.org/article/8bb35a77f6744d2dbe67f65cb91afeaf
Autor:
Philip Rößler, Stephan Grzesiek, Layara Abiko, Feng-Jie Wu, Daniel Häussinger, Pascal Rieder, Alvar Gossert
Publikováno v:
Journal of the American Chemical Society, 144 (47)
NMR chemical shift changes can report on the functional dynamics of biomacromolecules in solution with sizes >1 MDa. However, their interpretation requires chemical shift assignments to individual nuclei, which for large molecules often can only be o
Autor:
Jutta Nesper, Isabelle Hug, Setsu Kato, Chee-Seng Hee, Judith Maria Habazettl, Pablo Manfredi, Stephan Grzesiek, Tilman Schirmer, Thierry Emonet, Urs Jenal
Publikováno v:
eLife, Vol 6 (2017)
The flagellar motor is a sophisticated rotary machine facilitating locomotion and signal transduction. Owing to its important role in bacterial behavior, its assembly and activity are tightly regulated. For example, chemotaxis relies on a sensory pat
Externí odkaz:
https://doaj.org/article/e93454e00cad4837a3a25d5067358008
Autor:
Wolfgang Jahnke, Johannes Paladini, Judith M. Habazettl, Andrea Wiget, Alice Loo, Sandra W. Cowan Jacob, Stephan Grzesiek, Paul W. Manley
Publikováno v:
Angewandte Chemie. 134
Soellner published on the interplay between allosteric and adenosine triphosphate (ATP)-competitive inhibitors of ABL kinase, showing that the latter preferably binds to different conformational states of ABL compared to allosteric agents that specif
Autor:
Polina Isaikina, Ivana Petrovic, Roman P. Jakob, Parishmita Sarma, Ashutosh Ranjan, Minakshi Baruah, Vineet Panwalkar, Timm Maier, Arun K. Shukla, Stephan Grzesiek
SummaryThe two non-visual arrestin isoforms, arrestin2 and arrestin3 recognize and bind hundreds of G protein-coupled receptors (GPCRs) with different phosphorylation patterns leading to distinct functional outcomes. The impact of phosphorylation on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32ef341d37d8c1b89ec1eb120b3e89bd
https://doi.org/10.1101/2022.10.10.511578
https://doi.org/10.1101/2022.10.10.511578
Autor:
Polina, Isaikina, Ching-Ju, Tsai, Ivana, Petrovic, Marco, Rogowski, Alexandra Meng, Dürr, Stephan, Grzesiek
Publikováno v:
Methods in cell biology. 169
The numerous chemokines and their cognate G protein-coupled chemokine receptors on the surface of leukocytes form a complex signaling network, which regulates the immune response and also other key physiological processes. Currently only a very limit
Autor:
Layara Akemi Abiko, Marco Rogowski, Antoine Gautier, Gebhard F. X. Schertler, Stephan Grzesiek
Publikováno v:
Journal of Biomolecular Nmr
G protein-coupled receptors (GPCRs) are transmembrane signal transducers which regulate many key physiological process. Since their discovery, their analysis has been limited by difficulties in obtaining sufficient amounts of the receptors in high-qu
It was recently reported (Xie et al. Journal of Molecular Biology 2022, 434 (2), 167349) that the Abelson tyrosine kinase (Abl) ATP-site inhibitor imatinib also binds to Abl’s myristoyl binding pocket, which is the target of allosteric Abl inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e914700f9d46fdbe0638a99ebfccbf68
https://mr.copernicus.org/preprints/mr-2022-6/
https://mr.copernicus.org/preprints/mr-2022-6/