Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Stephan, Dickgiesser"'
Autor:
Nadine Barron, Stephan Dickgiesser, Markus Fleischer, Angelika-Nicole Bachmann, Daniel Klewinghaus, Jens Hannewald, Elke Ciesielski, Ilja Kusters, Til Hammann, Volker Krause, Sebastian Winfried Fuchs, Vanessa Siegmund, Alec W. Gross, Dirk Mueller-Pompalla, Simon Krah, Stefan Zielonka, Achim Doerner
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 4, p 2097 (2024)
The toolbox of modern antibody engineering allows the design of versatile novel functionalities exceeding nature’s repertoire. Many bispecific antibodies comprise heterodimeric Fc portions recently validated through the approval of several bispecif
Externí odkaz:
https://doaj.org/article/2a8c4343cce54ff487ec91bc8cbadac0
Autor:
Nora Tir, Lina Heistinger, Clemens Grünwald-Gruber, Leo A. Jakob, Stephan Dickgiesser, Nicolas Rasche, Diethard Mattanovich
Publikováno v:
Microbial Cell Factories, Vol 21, Iss 1, Pp 1-16 (2022)
Abstract Background Expansion of the genetic code is a frequently employed approach for the modification of recombinant protein properties. It involves reassignment of a codon to another, e.g., unnatural, amino acid and requires the action of a pair
Externí odkaz:
https://doaj.org/article/5a05cf744b974540bff7da90dfbf2737
Autor:
Sebastian Jäger, Harald Kolmar, Stephan Dickgiesser, Stefan Hecht, Jason Tonillo, Christian Schröter
Publikováno v:
Biological Chemistry. 403:525-534
The exposition of cancer cells to cytotoxic doses of payload is fundamental for the therapeutic efficacy of antibody drug conjugates (ADCs) in solid cancers. To maximize payload exposure, tissue penetration can be increased by utilizing smaller-sized
Autor:
Ulrich A. K. Betz, Tim Knehans, Jason Tonillo, Stefan Hecht, Dirk Mueller-Pompalla, Jan Anderl, Christian Schröter, Doreen Könning, Sabine Raab-Westphal, Nicolas Rasche, Shira Warszawski, Stefanie Kühn, Julia Dotterweich, Stephan Dickgiesser, Marcel Rieker
Publikováno v:
Bioconjugate Chemistry. 31:1070-1076
Site-specific bioconjugation technologies are frequently employed to generate homogeneous antibody-drug conjugates (ADCs) and are generally considered superior to stochastic approaches like lysine coupling. However, most of the technologies developed
Autor:
Gerhard Stadlmayr, Florian Stracke, Katharina Stadlbauer, Jakub Rybka, Stephan Dickgiesser, Nicolas Rasche, Stefan Becker, Lars Toleikis, Florian Rüker, Gordana Wozniak Knopp
Publikováno v:
Biochimica et biophysica acta. General subjects. 1866(7)
Site-specific coupling of toxin entities to antibodies has become a popular method of synthesis of antibody-drug conjugates (ADCs), as it leads to a homogenous product and allows a free choice of a convenient site for conjugation.We introduced a shor
Autor:
Anna Kaempffe, Elisa Bertotti, Federico Riccardi Sirtori, Doreen Könning, Nicolas Rasche, Roland Kellner, Stefan Hecht, Stephan Dickgiesser, Jan Anderl, Ilse De Salve, Harald Kolmar, Andrea Paoletti, Christian Schröter
Publikováno v:
Journal of pharmaceutical sciences. 110(12)
Appropriate selection of conjugation sites and conjugation technologies is now widely accepted as crucial for the success of antibody-drug conjugates (ADCs). Herein, we present ADCs conjugated by different conjugation methods to different conjugation
Publikováno v:
Learning Materials in Biosciences ISBN: 9783030546298
Antibody–drug conjugates (ADCs) are complex molecules that consist of a monoclonal antibody (mAb) equipped with a small molecule drug. The antibody specifically guides a cytotoxic agent to diseased cells while sparing healthy tissue, ultimately res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::671b3d0fa6584818e93f2f39ac005180
https://doi.org/10.1007/978-3-030-54630-4_8
https://doi.org/10.1007/978-3-030-54630-4_8
Autor:
Sebastian Jäger, Stephan Dickgiesser, Doreen Könning, Christian Schröter, Janis Rosskopf, Harald Kolmar, Simon Krah, Nicolas Rasche, Stefan Hecht
Publikováno v:
Methods in Molecular Biology ISBN: 9781493998524
Anti-hapten antibodies are widely used as specific immunochemical detection tools in a variety of clinical and environmental analyses. The sensitivity, however, is limited due to the resulting antibody affinities to the haptens which, in turn, leads
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a49fa378fa2ed84d3153cc2f888cdee
https://doi.org/10.1007/978-1-4939-9853-1_15
https://doi.org/10.1007/978-1-4939-9853-1_15
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2033
Antibody-drug conjugates (ADCs) have been proven to be a successful therapeutic concept, allowing targeted delivery of highly potent active pharmaceutical ingredients (HPAPIs) selectively to tumor tissue. So far, HPAPIs have been mainly attached to t
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2012
Antibody-drug conjugates (ADCs) are a relatively young class of cancer therapeutics that combine the superior selectivity of monoclonal antibodies (mAbs) with the high potency of cytotoxic agents. In the first generation of ADCs, the toxic payload is