Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Stepan Vyskocil"'
Autor:
Alexandra E. Gould, Courtney Cullis, Lee Hong Myung, David Lok, Rachel E. Gershman, Scott R. Rowland, Miho Mizutani, Dave Janowick, Gipson Krista E, Vihren Kolev, Robert J. Griffin, Joe Conlon, Steve Stroud, Akito Hata, Jeffrey Ciavarri, Dylan Bradley England, Cardin David P, Sandeep Pusalkar, Paul D. Greenspan, Adnan O Abu-Yousif, Jenna Malley, Doanh Mai, Michael Shaw, Ji Zhang, Robert J. Skene, Hu Zhigen, Matthew A. Jones, Atsushi Matsuda, Shih-Chung Huang, Nina Molchanova, Xu Tianlin, Jian Huang, He Xu, Stepan Vyskocil, Nanda Gulavita, Francois Soucy, Gang Li, Yongbo Hu, Liting Ma, Steven P. Langston, Zhan Shi, Christelle C. Renou, Luhua Shen, Sean Harrison, Elise Nunes, Kenneth M. Gigstad, Yosuke Sato, Hirotake Mizutani
Publikováno v:
Journal of Medicinal Chemistry. 64:6902-6923
Stimulator of Interferon Genes (STING) plays an important role in innate immunity by inducing type I interferon production upon infection with intracellular pathogens. STING activation can promote increased T-cell activation and inflammation in the t
Autor:
Ahmed F. Abdel-Magid, Jaan A. Pesti, Rajappa Vaidyanathan, Hirotaki Mizutani, Steven Langston, Stepan Vyskocil, Ian Armitage, Ashley McCarron, Lei Zhu, Ian M. Bell, Paul G. Bulger, Mark McLaughlin, Jason S. Tedrow, Wenge Zhong, Christian Harcken, Hossein Razavi, Jonathan T. Reeves, Daniel R. Fandrick, Jinhua J. Song, Zhulin Tan, Soojin Kim, Bing-Shiou Yang, Nathan K. Yee, Chris H. Senanayake, Remy Angelaud, Daniel P. Sutherlin, Mark Reynolds, Scott Savage, Andreas Stumpf, Srinivasan Babu, Francis Gosselin, Theresa Humphries, Alan Olivero, Daniel Sutherlin, Qingping Tian, Erick W. Co, Julian P. Henschke
Autor:
Emily F. Calderwood, Kathleen Aertgeerts, Michael D. Smith, Dylan Bradley England, Roushan Afroze, Ryan Chau, Stepan Vyskocil, Nancy E. Forsyth, Dong Mei Zhang, Ruth Adams, Stephen G. Stroud, O. P. Veiby, Christelle C. Renou, R. Scott Rowland, Erin Paske, Jane X. Liu, Ming Tregay, Michael D. Sintchak, Juliet A Williams, Shih-Chung Huang, Xu Tianlin, Bheemashankar Kulkarni, Sharmila Adhikari, Yuan Tian, Jason Yano, Christopher Blackburn, Paul D. Greenspan, Cheryl A. Farrer, Matthew O. Duffey, Liting Ma, Mi-Sook Kim, Qin Zhang, Sean Harrison, Hirotake Mizutani, Katherine M. Galvin, Alexandra E. Gould, Johnny J. Yang, Steven P. Langston, Dave Janowick, Natalia Iartchouk, Mansoureh Rezaei, Jeffery Gaulin, Khristofer Garcia, Hongbo Zeng, Ribo Guo, Tricia J. Vos, Jouhara Chouitar, Saurabh Menon
Publikováno v:
Journal of Medicinal Chemistry. 54:1836-1846
Inhibition of mutant B-Raf signaling, through either direct inhibition of the enzyme or inhibition of MEK, the direct substrate of Raf, has been demonstrated preclinically to inhibit tumor growth. Very recently, treatment of B-Raf mutant melanoma pat
Autor:
Ivo Stary, Sylvain Juge, Adrian Kollárovič, Stepan Vyskocil, Patrick J. Guiry, Guy C. Lloyd-Jones, Angelina Andronova, Irena G. Stará
Publikováno v:
Collection of Czechoslovak Chemical Communications. 76:2005-2022
The enantioselective [2+2+2] cycloisomerisation of the aromatic triynes under nickel(0) catalysis to afford nonracemic [6]- and [7]helicene derivatives has been systematically studied. A collection of mono- and bidentate phosphines, phosphites, phosp
Autor:
Teresa A. Soucy, Peter G. Smith, Michael A. Milhollen, Allison J. Berger, James M. Gavin, Sharmila Adhikari, James E. Brownell, Kristine E. Burke, David P. Cardin, Stephen Critchley, Courtney A. Cullis, Amanda Doucette, James J. Garnsey, Jeffrey L. Gaulin, Rachel E. Gershman, Anna R. Lublinsky, Alice McDonald, Hirotake Mizutani, Usha Narayanan, Edward J. Olhava, Stephane Peluso, Mansoureh Rezaei, Michael D. Sintchak, Tina Talreja, Michael P. Thomas, Tary Traore, Stepan Vyskocil, Gabriel S. Weatherhead, Jie Yu, Julie Zhang, Lawrence R. Dick, Christopher F. Claiborne, Mark Rolfe, Joseph B. Bolen, Steven P. Langston
Publikováno v:
Nature. 458:732-736
The clinical development of an inhibitor of cellular proteasome function suggests that compounds targeting other components of the ubiquitin-proteasome system might prove useful for the treatment of human malignancies. NEDD8-activating enzyme (NAE) i
Autor:
Taotao Ling, Michael O. Frederick, Wenjun Tang, Yoichi M. A. Yamada, Theocharis V. Koftis, Goran Petrovic, David Y.-K. Chen, Kyriacos C. Nicolaou, Yiwei Li, Stepan Vyskocil, Masayuki Satake
Publikováno v:
Angewandte Chemie. 116:4412-4418
Autor:
Michael O. Frederick, Stepan Vyskocil, Theocharis V. Koftis, Kyriacos C. Nicolaou, Taotao Ling, Goran Petrovic, Wenjun Tang, Yoichi M. A. Yamada
Publikováno v:
Angewandte Chemie. 116:4418-4424
Publikováno v:
Chemical Reviews. 103:3213-3246
Autor:
K. A. Kochetkov, A. S. Sagiyan, N. A. Kuz'mina, Syuzanna R. Harutyunyan, Victor I. Maleev, T. F. Savel'eva, Stepan Vyskocil, Alexander S. Peregudov
Publikováno v:
Russian Chemical Bulletin. 50:1620-1624
Alkali metal salts of substituted (S)-prolines, alkali metal alkoxides of (S)-prolinol, and Na salts of chiral substituted 2-amino-2"-hydroxy-1,1"-binaphthyls can catalyze the asymmetric Michael reaction of diethyl malonate with crotonaldehyde to giv
Autor:
N. S. Ikonnikov, Konstantin A. Kochetkov, Tatiana D. Churkina, Henri B. Kagan, Yuri N. Belokon, Stepan Vyskocil
Publikováno v:
Tetrahedron: Asymmetry. 10:1723-1728
Enantiopure 2-hydroxy-2′-amino-1,1′-binaphthyl (NOBIN) is shown to catalyse C-alkylation of aldimine Schiff's bases of alanine ester under phase-transfer catalysis conditions (solid NaOH or NaH, toluene, ambient temperature, 10% NOBIN). Using (R)