Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Stepan Nersisyan"'
Autor:
Arun Everest‐Dass, Stepan Nersisyan, Hanna Maar, Victor Novosad, Jennifer Schröder‐Schwarz, Vera Freytag, Johanna L. Stuke, Mia C. Beine, Alina Schiecke, Marie‐Therese Haider, Malte Kriegs, Omar Elakad, Hanibal Bohnenberger, Lena‐Christin Conradi, Maria Raygorodskaya, Linda Krause, Mark vonItzstein, Alexander Tonevitsky, Udo Schumacher, Diana Maltseva, Daniel Wicklein, Tobias Lange
Publikováno v:
Molecular Oncology, Vol 18, Iss 1, Pp 62-90 (2024)
Hematogenous metastasis limits the survival of colorectal cancer (CRC) patients. Here, we illuminated the roles of CD44 isoforms in this process. Isoforms 3 and 4 were predominantly expressed in CRC patients. CD44 isoform 4 indicated poor outcome and
Externí odkaz:
https://doaj.org/article/c19589a2bdca416b84704f2b8e082ac3
Autor:
Vladimir Staroverov, Stepan Nersisyan, Alexei Galatenko, Dmitriy Alekseev, Sofya Lukashevich, Fedor Polyakov, Nikita Anisimov, Alexander Tonevitsky
Publikováno v:
PeerJ, Vol 11, p e14828 (2023)
Mathematical modeling is widely used to study within-host viral dynamics. However, to the best of our knowledge, for the case of SARS-CoV-2 such analyses were mainly conducted with the use of viral load data and for the wild type (WT) variant of the
Externí odkaz:
https://doaj.org/article/07cac33da9d1411a8a20aa87e41e48ed
Autor:
Maxim Shkurnikov, Stepan Nersisyan, Darya Averinskaya, Milena Chekova, Fedor Polyakov, Aleksei Titov, Dmitriy Doroshenko, Valery Vechorko, Alexander Tonevitsky
Publikováno v:
PeerJ, Vol 11, p e14707 (2023)
In mid-2021, the SARS-CoV-2 Delta variant caused the third wave of the COVID-19 pandemic in several countries worldwide. The pivotal studies were aimed at studying changes in the efficiency of neutralizing antibodies to the spike protein. However, mu
Externí odkaz:
https://doaj.org/article/88e9b0482c404d02ab62ea3d6f50d781
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
A widely used procedure for selecting significant miRNA-mRNA or isomiR-mRNA pairs out of predicted interactions involves calculating the correlation between expression levels of miRNAs/isomiRs and mRNAs in a series of samples. In this manuscript, we
Externí odkaz:
https://doaj.org/article/7b6f0b2c56b743d984e5a599f4f74ba1
Autor:
Stepan Nersisyan, Aleksandra Gorbonos, Alexey Makhonin, Anton Zhiyanov, Maxim Shkurnikov, Alexander Tonevitsky
Publikováno v:
PeerJ, Vol 10, p e14205 (2022)
Inaccurate cleavage of pri- and pre-miRNA hairpins by Drosha and Dicer results in the generation of miRNA isoforms known as isomiRs. isomiRs with 5′-end variations (5′-isomiRs) create a new dimension in miRNA research since they have different se
Externí odkaz:
https://doaj.org/article/fb3c4875b5394ae4b7abf84b500502f2
Immunogenic epitope panel for accurate detection of non-cross-reactive T cell response to SARS-CoV-2
Autor:
Aleksei Titov, Regina Shaykhutdinova, Olga V. Shcherbakova, Yana V. Serdyuk, Savely A. Sheetikov, Ksenia V. Zornikova, Alexandra V. Maleeva, Alexandra Khmelevskaya, Dmitry V. Dianov, Naina T. Shakirova, Dmitry B. Malko, Maxim Shkurnikov, Stepan Nersisyan, Alexander Tonevitsky, Ekaterina Khamaganova, Anton V. Ershov, Elena Y. Osipova, Ruslan V. Nikolaev, Dmitry E. Pershin, Viktoria A. Vedmedskia, Michael Maschan, Victoria R. Ginanova, Grigory A. Efimov
Publikováno v:
JCI Insight, Vol 7, Iss 9 (2022)
The ongoing COVID-19 pandemic calls for more effective diagnostic tools. T cell response assessment serves as an independent indicator of prior COVID-19 exposure while also contributing to a more comprehensive characterization of SARS-CoV-2 immunity.
Externí odkaz:
https://doaj.org/article/f3a2a8cc553a465b87e4da680fdb63db
Autor:
Stepan Nersisyan, Anton Zhiyanov, Maria Zakharova, Irina Ishina, Inna Kurbatskaia, Azad Mamedov, Alexei Galatenko, Maxim Shkurnikov, Alexander Gabibov, Alexander Tonevitsky
Publikováno v:
PeerJ, Vol 10, p e13354 (2022)
The T-cell immune response is a major determinant of effective SARS-CoV-2 clearance. Here, using the recently developed T-CoV bioinformatics pipeline (https://t-cov.hse.ru) we analyzed the peculiarities of the viral peptide presentation for the Omicr
Externí odkaz:
https://doaj.org/article/ed7b7c80f18e408391dab46e287e6996
Autor:
Stepan Nersisyan, Victor Novosad, Alexei Galatenko, Andrey Sokolov, Grigoriy Bokov, Alexander Konovalov, Dmitry Alekseev, Alexander Tonevitsky
Publikováno v:
PeerJ, Vol 10, p e13200 (2022)
Feature selection is one of the main techniques used to prevent overfitting in machine learning applications. The most straightforward approach for feature selection is an exhaustive search: one can go over all possible feature combinations and pick
Externí odkaz:
https://doaj.org/article/c522171986b048359fd92c4888e2f2b2
Autor:
Stepan Nersisyan, Victor Novosad, Narek Engibaryan, Yuri Ushkaryov, Sergey Nikulin, Alexander Tonevitsky
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Interactions of the extracellular matrix (ECM) and cellular receptors constitute one of the crucial pathways involved in colorectal cancer progression and metastasis. With the use of bioinformatics analysis, we comprehensively evaluated the prognosti
Externí odkaz:
https://doaj.org/article/770ee80cf3184dc49eedef32031dbfa1
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Since 2003, the world has been confronted with three new betacoronaviruses that cause human respiratory infections: SARS-CoV, which causes severe acute respiratory syndrome (SARS), MERS-CoV, which causes Middle East respiratory syndrome (MERS), and S
Externí odkaz:
https://doaj.org/article/550b4c1e28484d1184ee4f35c5ca36b5