Monoclonal antibody therapy efficacy can be boosted by combinations with other treatments: Predictions using an integrated Alzheimer’s Disease Platform

Autor: Oleg O Demin, Alexandr Stepanov, Tatiana Karelina, Stepan Lerner, Mark Meerson

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 6, Pp 543-550 (2021)
CPT: Pharmacometrics & Systems Pharmacology

For many years, clinical research in Alzheimer’s disease (AD) has focused on attempts to identify the most explicit biomarker, namely amyloid beta. Unfortunately, the numerous therapies that have been developed have failed in clinical practice. AD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b858e9e37185273e0eadfe4f8276379c
https://doaj.org/article/1469ef7fa5664addaa330de58cbeb12d

Description of amyloid beta influence on synaptic plasticity and tau hyperphosphorylation by mechanistic quantitative systems pharmacology model

Autor: Tatiana Karelina, Stepan Lerner

Publikováno v: Alzheimer's & Dementia. 16

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4d7b5afccdaa002653c2be2f23df0515
https://doi.org/10.1002/alz.042926