Výsledky vyhledávání - "Stepan G. Pilyo"

Akademický článek

Inhibition of Xanthine Oxidase by Pyrazolone Derivatives Bearing a 4-(Furan-2-yl)benzoic Acid Moiety

Autor: Alona V. Beiko, Oleksandr L. Kobzar, Maryna V. Kachaeva, Stepan G. Pilyo, Vsevolod Yu. Tanchuk, Andriy I. Vovk

Publikováno v: Журнал органічної та фармацевтичної хімії, Vol 21, Iss 4, Pp 27-35 (2023)

The pyrazolone-based 4-(furan-2-yl)benzoic acids have been synthesized and studied as xanthine oxidase inhibitors. This enzyme is one of the therapeutic targets for the treatment of hyperuricemia and related diseases. The compounds studied have found

Externí odkaz: https://doaj.org/article/c837628d2ff64610be2c10ef61c2a44b

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In silico study the interaction of heterocyclic bases with peptide moieties of proteins in the 'fragment-to-fragment' approach

Autor: Nataliya Obernikhina, Yevheniia Velihina, Maryna V. Kachaeva, Stepan G. Pilyo, Oleksiy Kachkovsky

Publikováno v: Ukr. Bioorg. Acta 2021, Vol. 16, N1. 16:34-43

The binding affinity of model peptide moieties (Pept) and heterocyclic bases involving 1,3-oxazoles that are condensed with pyridine and pyrimidine as pharmacophores (Pharm) was investigated in silico and analyzed within the «fragment-to-fragment»

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cb5d1e3e7adaec1fe790068dd3a96c14
https://doi.org/10.15407/10.15407/bioorganica2021.01.034

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Synthesis and evaluation of new thiazole-containing rhodanine-3-alkanoic acids as inhibitors of protein tyrosine phosphatases and glutathione S-transferases

Autor: Vlasyslav Buldenko, Oleksandr L. Kobzar, Yuriy Shulha, Andriy I. Vovk, Diana Hodyna, Stepan G. Pilyo, Volodymyr Brovarets, V. O. Sinenko

Publikováno v: Ukr. Bioorg. Acta 2020, Vol. 15, N2. 15:33-40

Thiazole-containing derivatives of rhodanine-3-alkanoic acids with propanoic or undecanoic acid groups were synthesized and evaluated as inhibitors of some protein tyrosine phosphatases and glutathione S-transferases. The rhodanines bearing longer ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::01b0062b1908ac79a68dd308d151ce92
https://doi.org/10.15407/bioorganica2020.02.033

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In silico study of binding affinity of nitrogenous bicyclic heterocycles: fragment-to-fragment approach

Autor: Nataliya Obernikhina, Stepan G. Pilyo, Volodymyr Brovarets, Oleksiy Kachkovsky, Yevheniia Velihina, Maryna V. Kachaeva

Publikováno v: Ukr. Bioorg. Acta 2020, Vol. 15, N2. 15:49-59

The binding affinity of model aromatic amino acids and heterocycles and their derivatives condensed with pyridine were investigated in silico and are presented in the framework of fragment-to-fragment approach. The presented model describes interacti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::62bdb16742ee3843b93385da0bcb2a07
https://doi.org/10.15407/bioorganica2020.02.049

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Synthesis and in vitro anticytomegalovirus activity of 5-hydroxyalkylamino-1,3-oxazoles derivatives

Autor: Stepan G. Pilyo, Victor V. Zhirnov, V. S. Brovarets, Emma A. Harden, Mark N. Prichard, Nataliya V. Velychko, Mykhailo Y. Brusnakov, Scott H. James, Oleksandr V. Golovchenko, E. R. Abdurakhmanova

Publikováno v: Medicinal Chemistry Research. 29:1669-1675

A series of derivatives of 5-hydroxyalkylamino-1,3-oxazoles were synthesized. Among these derivatives, 5 compounds have been evaluated for their activities against a normal laboratory human cytomegalovirus (HCMV) strain, AD169, in human foreskin fibr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f19c1a6b5430475f98d965c7a9a6f0b6
https://doi.org/10.1007/s00044-020-02593-6

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Three-component cyclization as an approach to a combinatorial library of 2H-spiro-[chromeno[2,3-c]pyrrole-1,3'-indoline]-2',3,9-triones

Autor: Andriy V. Kozytskiy, Maryna V. Kachaeva, O. V. Shablykina, R. N. Vydzhak, Volodymyr Brovarets, Stepan G. Pilyo, V. S. Moskvina

Publikováno v: Ukr. Bioorg. Acta 2020, Vol. 15, N1. 15:26-33

A versatile and efficient three-component cyclization of methyl 4-(o-hydroxyphenyl)-2,4-dioxobutanoates 1, N-substituted isatins 2, and primary amines 3 was explored to synthesize of 2H-spiro[chromeno[2,3-c]pyrrole-1,3'-indoline]-2',3,9-triones. We o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0596d4174b473d5a523da89a955e9233
https://doi.org/10.15407/bioorganica2020.01.026

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In vitro activity of novel derivatives of 1,3-oxazole-4-carboxylate and 1,3-oxazole-4-carbonitrile against human cytomegalovirus

Autor: Emma A. Harden, Volodymyr Brovarets, Caroll B. Hartline, Victor V. Zhirnov, Maryna V. Kachaeva, Stepan G. Pilyo, Mark N. Prichard

Publikováno v: Medicinal Chemistry Research. 28:1205-1211

Ten 5-functionalized derivatives of 1,3-oxazole-4-carboxylate and 1,3-oxazole-4-carbonitrile were synthesized and their antiviral activities against the human cytomegalovirus (HCMV) were evaluated in vitro. Bioassays showed that seven compounds exhib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ed324439dd31eba917e40de3eecb45d3
https://doi.org/10.1007/s00044-019-02365-x

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Rapid synthetic approaches to libraries of diversified 1,2-dihydrochromeno[2,3-c]pyrrole-3,9-diones and 3-(2-hydroxyphenyl)-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones

Autor: Volodymyr Brovarets, Andriy V. Kozytskiy, Stepan G. Pilyo, R. N. Vydzhak, O. V. Shablykina, V. S. Moskvina, Svitlana Ya. Panchishin, Maryna V. Kachaeva

Publikováno v: Molecular Diversity

Graphic abstract An efficient and practical synthetic procedure for libraries of diversified 1,2-dihydrochromeno[2,3-c]pyrrole-3,9-diones using a multicomponent process is presented. A convenient synthetic procedure for obtaining functionalized 3-(2-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b3eaa5442d5d8584af8eea9b292efbd
https://pubmed.ncbi.nlm.nih.gov/34086156

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