Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Stepan Chuprakov"'
Autor:
Penelope M. Drake, David Rabuka, Mark D. Pegram, Colin Hickle, Dominick Yeo, Ayodele O. Ogunkoya, Maxine Bauzon, Fangjiu Zhang, Stepan Chuprakov, Yun Cheol Kim, Robyn M. Barfield
Contains 3 tables and 8 figures with legends.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09b90b891f0338273763849f4ed50af1
https://doi.org/10.1158/1535-7163.22521129
https://doi.org/10.1158/1535-7163.22521129
Autor:
Fangjiu Zhang, Ayodele O. Ogunkoya, David Rabuka, Penelope M. Drake, Colin Hickle, Maxine Bauzon, Yun Cheol Kim, Dominick Yeo, Robyn M. Barfield, Stepan Chuprakov
Publikováno v:
Bioconjugate Chemistry. 32:746-754
Although peptide motifs represent the majority of cleavable linkers used in clinical-stage antibody-drug conjugates (ADCs), the sequences are often sensitive to cleavage by extracellular enzymes, such as elastase, leading to systemic release of the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40dc867df1e6c62ea7d5dd6162086eff
https://doi.org/10.1021/acs.bioconjchem.1c00029
https://doi.org/10.1021/acs.bioconjchem.1c00029
Autor:
Stepan Chuprakov, Fangjiu Zhang, Yun Cheol Kim, David Rabuka, Dominick Yeo, Robyn M. Barfield, Penelope M. Drake, Ayodele O. Ogunkoya, Mark D. Pegram, Maxine Bauzon, Colin Hickle
Publikováno v:
Molecular Cancer Therapeutics. 19:1866-1874
Trastuzumab and the related antibody-drug conjugate (ADC), ado-trastuzumab emtansine (T-DM1), both target HER2-overexpressing cells. Together, these drugs have treatment indications in both early-stage and metastatic settings for HER2+ breast cancer.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb6c34d486576f054d4a1ee8a2e10261
https://doi.org/10.1158/1535-7163.mct-20-0190
https://doi.org/10.1158/1535-7163.mct-20-0190
Publikováno v:
Journal of the American Chemical Society. 136:195-202
Rhodium(II) azavinyl carbenes, conveniently generated from 1-sulfonyl-1,2,3-triazoles, undergo a facile, mild, and convergent formal 1,3-insertion into N-H and O-H bonds of primary and secondary amides, various alcohols, and carboxylic acids to affor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::812ac52a5614a1198132f9bf651ee089
https://doi.org/10.1021/ja408185c
https://doi.org/10.1021/ja408185c
Publikováno v:
Journal of the American Chemical Society. 134:14670-14673
A highly efficient and stereoselective arylation of in situ-generated azavinyl carbenes affording 2,2-diaryl enamines at ambient temperatures has been developed. These transition-metal carbenes are directly produced from readily available and stable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c41991a9c8437ec1b384a58bed3ae4b9
https://doi.org/10.1021/ja3062453
https://doi.org/10.1021/ja3062453
Publikováno v:
Journal of the American Chemical Society. 133:10352-10355
A highly efficient enantioselective C–H insertion of azavinyl carbenes into unactivated alkanes has been developed. These transition metal carbenes are directly generated from readily available and stable 1-sulfonyl-1,2,3-triazoles in the presence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91cb7d0c4bde0068ab4fd4f3f30a2b0f
https://doi.org/10.1021/ja202969z
https://doi.org/10.1021/ja202969z
Publikováno v:
Organic Letters. 9:2333-2336
A highly efficient method for the synthesis of multisubstituted 1,2,3-triazoles via a direct Pd-catalyzed C-5 arylation has been developed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ce0524f4d74b436d3ba6721175bfdb6
https://doi.org/10.1021/ol070697u
https://doi.org/10.1021/ol070697u
Publikováno v:
Russian Journal of Organic Chemistry. 39:1016-1020
Reactions of 2-(β-ethoxyvinyl)-4,4,5,5-tetramethyl-4,5-dihydro-1,3-dioxol-1-ium salts with cyanomethylene compounds gave the corresponding 2-(2-propenylidene)-1,3-dioxolane derivatives which reacted with hydrazine and primary amines to afford, respe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca118ba22d9c7c176b0446e413e33ee6
https://doi.org/10.1023/b:rujo.0000003195.45227.03
https://doi.org/10.1023/b:rujo.0000003195.45227.03
Publikováno v:
ChemInform. 45
Rhodium(II) azavinyl carbenes generated from sulfonyltriazoles, undergo a facile, mild, and convergent formal 1,3-insertion into N—H and O—H bonds of primary and secondary amides, various alcohols, and carboxylic acids to afford a wide range of v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c239329c06802f4ba53be5882c27c744
https://doi.org/10.1002/chin.201430069
https://doi.org/10.1002/chin.201430069
Publikováno v:
Journal of the American Chemical Society. 130:14972-14974
Stable and readily available 1-sulfonyl triazoles are converted to the corresponding imidazoles in good to excellent yields via a rhodium(II)-catalyzed reaction with nitriles. Rhodium iminocarbenoids are proposed intermediates.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81f364024adb8572745ad91bee2c2de7
https://doi.org/10.1021/ja805079v
https://doi.org/10.1021/ja805079v