Lu AA21004, a novel multimodal antidepressantwith activity exerted through serotonergic targets

Autor: Mork, A., Pehrson, A., Montezinho, L. C. P., Karlsson, J. J., Murphy, C. T., Miller, S., Sanchez, C., Fischer, C. W., Liebenberg, N., Gregers Wegener, Bang-Andersen, B., Stensbol, T. B.

Publikováno v: Mork, A, Pehrson, A, Montezinho, L C P, Karlsson, J J, Murphy, C T, Miller, S, Sanchez, C, Fischer, C W, Liebenberg, N, Wegener, G, Bang-Andersen, B & Stensbol, T B 2012, ' Lu AA21004, a novel multimodal antidepressantwith activity exerted through serotonergic targets ', Biological Psychiatry, vol. 71, no. 8, pp. 299S-300S .
Aarhus University

Background: Lu AA21004 is a multimodal antidepressant that functions as a 5-HT3 and 5-HT7 receptor antagonist, 5-HT1B receptor partial agonist, 5-HT1A receptor agonist and inhibitor of the 5-HT transporter in vitro. Here we investigated preclinical e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::94a7535d5e7d1ad90a9f581e781919cb
https://pure.au.dk/portal/da/publications/lu-aa21004-a-novel-multimodal-antidepressantwith-activity-exerted-through-serotonergic-targets(0f6cd90e-c9bd-4df3-a86d-d96bca6e7985).html

Potent 4-Aryl- or 4-Arylalkyl-Substituted 3-Isoxazolol GABAA Antagonists:  Synthesis, Pharmacology, and Molecular Modeling

Autor: Frolund, B., Jensen, L. S., Guandalini, L., Canillo, C., Vestergaard, H. T., Kristiansen, U., Nielsen, B., Stensbol, T. B., Madsen, C., Krogsgaard-Larsen, P., Liljefors, T.

Publikováno v: Journal of Medicinal Chemistry; January 2005, Vol. 48 Issue: 2 p427-439, 13p

Synthesis and Anticonvulsant Activity of Novel Bicyclic Acidic Amino Acids

Autor: Conti, P., Amici, M. De, Ventimiglia, Joppolo di, S., Stensbol, T. B., Madsen, U., Brauner-Osborne, H., Russo, E., Sarro, G. De, Bruno, G., Micheli, C. D.

Publikováno v: Journal of Medicinal Chemistry; July 2003, Vol. 46 Issue: 14 p3102-3108, 7p

Three-Dimensional Structure of the Ligand-Binding Core of GluR2 in Complex with the Agonist (S)-ATPA:  Implications for Receptor Subunit Selectivity

Autor: Lunn, M.-L., Hogner, A., Stensbol, T. B., Gouaux, E., Egebjerg, J., Kastrup, J. S.

Publikováno v: Journal of Medicinal Chemistry; February 2003, Vol. 46 Issue: 5 p872-875, 4p

Novel Class of Potent 4-Arylalkyl Substituted 3-Isoxazolol GABAA Antagonists:  Synthesis, Pharmacology, and Molecular Modeling

Autor: Frolund, B., Jorgensen, A. T., Tagmose, L., Stensbol, T. B., Vestergaard, H. T., Engblom, C., Kristiansen, U., Sanchez, C., Krogsgaard-Larsen, P., Liljefors, T.

Publikováno v: Journal of Medicinal Chemistry; June 2002, Vol. 45 Issue: 12 p2454-2468, 15p