Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Stenne Brice M"'
Autor:
Alexandra S Needham, Akinola Soyode-Johnson, Kevin J. Coe, Bartosz Balana, Freddy Schoetens, Xiaohui Jiang, Daniel J. Pippel, Kia Sepassi, Chungfang Xia, Stenne Brice M, Brian Scott, Leslie Nguyen, Tatiana Koudriakova, Christa C. Chrovian, Brian Lord, Michael A. Letavic, Jeffrey Schoellerman
Publikováno v:
Journal of Medicinal Chemistry. 63:9181-9196
Selective inhibitors of the GluN2B subunit of N-methyl-d-aspartate receptors in the ionotropic glutamate receptor superfamily have been targeted for the treatment of mood disorders. We sought to identify structurally novel, brain penetrant, GluN2B-se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19f1743cefc51ebca30728bea44390f7
https://doi.org/10.1021/acs.jmedchem.9b02113
https://doi.org/10.1021/acs.jmedchem.9b02113
Autor:
Brock T. Shireman, Brian Lord, Nicholas I. Carruthers, Michael A. Letavic, Pascal Bonaventure, Anindya Bhattacharya, Tatiana Koudriakova, Dale A. Rudolph, Timothy W. Lovenberg, Ziff Jeannie M, Stenne Brice M
Publikováno v:
ACS chemical neuroscience. 7(4)
We describe the synthesis of a novel class of brain penetrating P2X7 antagonists with high potency at both the rat and human P2X7 receptors. Disclosed herein are druglike molecules with demonstrated target engagement of the rat P2X7 receptors after a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4cc6c9d05808f1e06852fbd7b5e1629
https://pubmed.ncbi.nlm.nih.gov/26754558
https://pubmed.ncbi.nlm.nih.gov/26754558