GWAS for autoimmune Addison's disease identifies multiple risk loci and highlights AIRE in disease susceptibility

Autor: Eriksson, D., Royrvik, E. C., Aranda-Guillen, M., Berger, A. H., Landegren, N., Artaza, H., Hallgren, A., Grytaas, M. A., Strom, S., Bratland, E., Botusan, I. R., Oftedal, B. E., Breivik, L., Vaudel, M., Helgeland, O., Falorni, A., Jorgensen, A. P., Hulting, A. -L., Svartberg, J., Ekwall, O., Fougner, K. J., Wahlberg, J., Nedrebo, B. G., Dahlqvist, P., Raeder, H., Jovanovic, N., Reisegg, S. C., Holleland, G., Carlsen, S., Berg, T. J., Eggesbo, J. B., Svendsen, T., Lima, K., Nermoen, I., Whitfield, R., Sollid, S., Aarskog, D., Korsgaard, E., Saeta, S., Finnes, T., Valland, S. F., Fossum, C., Brevik, E., Moe, R. B., Svendsen, M., Debowska, A., Milova, P., Holte, S., Tomkowicz, A. E., Sormo, D. E., Svare, A., Rensvik, M. L., Revheim, R., Haug, T., Blix, I., Jensen, L. P., Akerman, A. -K., Lindberg, B., Kristrom, B., Waldenstrom, E., Johannsson, G., Skov, J., Duchen, K., Isaksson, M., Elfving, M., Stenlid, M. H., Nilsson, O., Kampe, O., Bergthorsdottir, R., Nergardh, R., Bjornsdottir, S., Bensing, S., Olsson, T., Knappskog, P. M., Wolff, A. S. B., Johansson, S., Husebye, E. S.

Publikováno v: 959-?
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

Autoimmune Addison’s disease (AAD) is characterized by the autoimmune destruction of the adrenal cortex. Low prevalence and complex inheritance have long hindered successful genetic studies. We here report the first genome-wide association study on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80dfc40d7d7cb666067e7a95fd17121e
https://hdl.handle.net/11250/3036838