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pro vyhledávání: '"Stengel, Peter"'
Akademický článek
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Akademický článek
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Autor:
Stengel, Peter W., Zeckner, Douglas J., Guo, Wen-Kai Kevin, Wolos, Jeffrey A., Snyder, David W.
Publikováno v:
In European Journal of Pharmacology 2008 578(1):65-75
Publikováno v:
Journal of the Brazilian Chemical Society, Vol 9, Iss 4, Pp 345-356 (1998)
As an extension to our work on intramolecular annulations via silyloxycyclopropane derived anions, we have investigated the chemistry of cyclopentyl cyclopropane systems, 6-9, in an effort to prepare stereospecifically functionalized hydrindenones. T
Externí odkaz:
https://doaj.org/article/d4874e4265d04b25bf3dda57c158d354
Autor:
Yiamouyiannis, Carmen A., Schramm, Craig M., Puddington, Lynn, Stengel, Peter, Baradaran-Hosseini, Ebrahim, Wolyniec, Walter W., Whiteley, Herbert E., Thrall, Roger S.
Publikováno v:
In The American Journal of Pathology 1999 154(6):1911-1921
Autor:
Leonid Beigelman, Hailong Zhang, Benjamin T. Woodard, Christine Lemieux, Guy Vigers, Vlad Serebryany, Brad O. Buckman, Bin Wang, Scott D. Seiwert, Barbra J. Brandhuber, Steve Wenglowsky, Stengel Peter J, Andrews Steven W, Lawrence M. Blatt, Kennedy April L, Doherty George Andrew, John A. Josey, Joshua Ballard, Mary Geck Do, Madduru Machender R, Jiang Yutong, Kevin Ronald Condroski, Michael Lyon
Publikováno v:
Journal of Medicinal Chemistry. 57:1753-1769
HCV serine protease NS3 represents an attractive drug target because it is not only essential for viral replication but also implicated in the viral evasion of the host immune response pathway through direct cleavage of key proteins in the human inna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a178a8c726b6e9a5d39e501d2db8861d
https://doi.org/10.1021/jm400164c
https://doi.org/10.1021/jm400164c
Autor:
Vincent Leveque, Gloria Ao-Ieong, Sophie Le Pogam, Bamberg Joe Timothy, Javier de Vicente, Stengel Peter J, Stacey Renee Spencer, John P. Fischer, Todd R. Elworthy, Andrew J. Briggs, Jim Li, Peter Mohr, Michael Brandl, Sunil Sukhtankar, Ramona Hilgenkamp, Calvin Yee, Ludmila Alexandrova, Robinson John E, Fell Jay Bradford, Beihan Wang, April Wong, Robert Than Hendricks, Farrell Robert P, Isabel Najera, David Bernard Smith, Seth F. Harris, Sonal Rajyaguru, Susan Larrabee, James F. Blake, George Adjabeng
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5652-5656
A series of benzo[d]isothiazole-1,1-dioxides were designed and evaluated as inhibitors of HCV polymerase NS5B. Structure-based design led to the incorporation of a high affinity methyl sulfonamide group. Structure-activity relationship (SAR) studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::270693e52369b485d5d38536330a0ea0
https://doi.org/10.1016/j.bmcl.2009.08.022
https://doi.org/10.1016/j.bmcl.2009.08.022
Autor:
Elbert Chin, Manjiri Ghate, Vincent Leveque, Sonal Rajyaguru, Bill Fitch, Jahari Laurant Tracy, Michael Brandl, Steve A. de Keczer, Ramona Hilgenkamp, Fell Jay Bradford, Tatyana Voronin, Isabel Najera, Gloria Ao-Ieong, Javier de Vicente, Shao-Yong Wu, Beihan Wang, Stacey Renee Spencer, Stengel Peter J, Peter Mohr, Mohammad R. Masjedizadeh, James F. Blake, Robert Than Hendricks, Todd R. Elworthy, David Bernard Smith, Junping Zhao, Ludmila Alexandrova, Robinson John E, Al Lui, John P. Fischer, Seth F. Harris, Jim Li, Connie Oshiro, Calvin Yee, Sophie Le Pogam
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5648-5651
Benzothiazine-substituted tetramic acids were discovered as highly potent non-nucleoside inhibitors of HCV NS5B polymerase. X-ray crystallography studies confirmed the binding mode of these inhibitors with HCV NS5B polymerase. Rational optimization o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7482cb6bce12ac0c2b982d6fc4cff88a
https://doi.org/10.1016/j.bmcl.2009.08.023
https://doi.org/10.1016/j.bmcl.2009.08.023
Autor:
Stacey Renee Spencer, Vincent Leveque, Fell Jay Bradford, John A. Josey, Stengel Peter J, John P. Fischer, Robert Than Hendricks, April L. Bernacki, James F. Blake, Sophie Le Pogam, Sonal Rajyaguru, Steven Swallow, Robinson John E, Isabel Najera, Harris Jason R
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:3637-3641
The importance of internal hydrogen bonding in a series of benzothiadiazine and 1,4-benzothiazine NS5b inhibitors has been explored. Computational analysis has been used to compare the protonated vs. anionic forms of each series and we demonstrate th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::275a5fed7b4e0f2c32fc43549f46ac01
https://doi.org/10.1016/j.bmcl.2009.04.119
https://doi.org/10.1016/j.bmcl.2009.04.119
Autor:
Ludmila Alexandrova, Connie Oshiro, Ramona Hilgenkamp, Stengel Peter J, Isabel Najera, Peter Mohr, Jahari Laurant Tracy, Susan Larrabee, James F. Blake, David Bernard Smith, Bamberg Joe Timothy, George Adjabeng, Vincent Leveque, Andrew J. Briggs, Brian Xu, Seth F. Harris, Rebecca A. Stephenson, Sonal Rajyaguru, Manjiri Ghate, Beihan Wang, John P. Fischer, Stacey Renee Spencer, Calvin Yee, Sophie Le Pogam, Elbert Chin, Michael Brandl, Fell Jay Bradford, Gloria Ao-Ieong, Sunil Sukhtankar, Robert Than Hendricks, Jim Li, Robinson John E, Todd R. Elworthy, Farrell Robert P, Javier de Vicente
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:3642-3646
A new series of benzothiazine-substituted quinolinediones were evaluated as inhibitors of HCV polymerase NS5B. SAR studies on this series revealed a methyl sulfonamide group as a high affinity feature. Analogues with this group showed submicromolar p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af0673cb666121215e5519a1cfe7e1c9
https://doi.org/10.1016/j.bmcl.2009.05.004
https://doi.org/10.1016/j.bmcl.2009.05.004