Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Sten Kjellstrom"'
Autor:
Sten Kjellstrom, Paul A. Sieving, Lisa L. Wei, Camasamudram Vijayasarathy, Yong Zeng, H. Nida Sen, Zhijian Wu, Henry E. Wiley, Brett G. Jeffrey, Peter Colosi, J. Fraser Wright, Suja Hiriyanna, Ronald A. Bush, Catherine A Cukras, Amy Turriff, Tae Kwon Park, Dario Marangoni, Lucia Ziccardi
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy, vol 26, iss 9
This study evaluated the safety and tolerability of ocular RS1 adeno-associated virus (AAV8-RS1) gene augmentation therapy to the retina of participants with X-linked retinoschisis (XLRS). XLRS is a monogenic trait affecting only males, caused by mut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69a34bfd5a5f87ac28292b0bda77fd24
https://hdl.handle.net/11368/3002667
https://hdl.handle.net/11368/3002667
Autor:
Johanna Sundgren, Rafi Sheikh, Rannveig Linda Thorisdottir, Björn Hammar, Malin Malmsjö, Jonas Blohmé, Sten Kjellstrom
Publikováno v:
Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus. 22(4)
PURPOSE: To evaluate the digital KM screen computerized ocular motility test and to compare it with conventional nondigital techniques using the Hess and Lees screens.METHODS: Patients with known ocular deviations and a visual acuity of at least 20/1
Autor:
Ronald A. Bush, Anitha Yerrabelli, Tomohiro Masuda, Xiaodong Zhang, Jun Wan, Snorri S. Thorgeirsson, Sten Kjellstrom, Elizabeth A. Conner, Shiming Chen, Cindy Berlinicke, Anand Swaroop, Donald J. Zack
Publikováno v:
The Journal of Neuroscience. 34:15356-15368
The mechanisms that specify photoreceptor cell-fate determination, especially as regards to short-wave-sensitive (S) versus medium-wave-sensitive (M) cone identity, and maintain their nature and function, are not fully understood. Here we report the
Autor:
Dario Marangoni, Sten Kjellstrom, Camasamudram Vijayasarathy, Zeng Yong, Ronald A. Bush, Paul A. Sieving
Publikováno v:
Investigative Ophthalmology & Visual Science
Investigative ophthalmology & visual science, vol 58, iss 3
Investigative ophthalmology & visual science, vol 58, iss 3
Author(s): Marangoni, Dario; Yong, Zeng; Kjellstrom, Sten; Vijayasarathy, Camasamudram; A Sieving, Paul; Bush, Ronald A | Abstract: PurposeTo test the effects of rearing light intensity on retinal function and morphology in the retinoschisis knockout
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53998969074c4c9b2b2d038ddd4540a1
http://hdl.handle.net/11368/3002591
http://hdl.handle.net/11368/3002591
Autor:
Maria José Santos, Sten Kjellstrom, Peter Colosi, Zhijian Wu, Yong Zeng, Ronald A. Bush, Paul A. Sieving, Camasamudram Vijayasarathy, Jinbo Li, Suja Hiriyanna
Publikováno v:
Human gene therapy, vol 27, iss 5
Gene therapy for inherited retinal diseases has been shown to ameliorate functional and structural defects in both animal models and in human clinical trials. X-linked retinoschisis (XLRS) is an early-age onset macular dystrophy resulting from loss o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60db04c2fc94392dae286635d8504d8b
https://europepmc.org/articles/PMC4840830/
https://europepmc.org/articles/PMC4840830/
Autor:
Camasamudram Vijayasarathy, Vesna Ponjavic, Sten Andréasson, Paul A. Sieving, Sten Kjellstrom
Publikováno v:
Ophthalmic Genetics. 31:114-125
To investigate the retinal structure and function during the progression of X-linked retinoschisis (XLRS) from childhood to adulthood.Ten patients clinically diagnosed with XLRS were investigated at 6-15 years of age (mean age 9 years) with a follow-
Autor:
Yong Zeng, Sten Kjellstrom, T. K. Park, Paul A. Sieving, Zhijian Wu, Peter Colosi, Ronald A. Bush
Publikováno v:
Gene Therapy. 16:916-926
X-linked juvenile retinoschisis (XLRS) is a neurodevelopmental abnormality caused by retinoschisin gene mutations. XLRS is characterized by splitting through the retinal layers and impaired synaptic transmission of visual signals resulting in impaire
Autor:
A. Tanikawa, Rong Wen, Ying Song, Sten Kjellstrom, Alan M. Laties, Paul A. Sieving, Lian Zhao, Ronald A. Bush, Yun Liu, Yiwen Li
Publikováno v:
The Journal of Neuroscience. 26:13523-13530
Ciliary neurotrophic factor (CNTF) promotes photoreceptor survival but also suppresses electroretinogram (ERG) responses. This has caused concerns about whether CNTF is detrimental to the function of photoreceptors because it is considered to be a po
Publikováno v:
Documenta Ophthalmologica; 113(3), pp 179-186 (2006)
Purpose To evaluate retinal function and histopathology in rabbits treated orally with the antiepileptic drug topiramate. Methods Six rabbits were treated with a daily oral dose of topiramate during a period of eight months. Six rabbits receiving wat
Publikováno v:
Documenta Ophthalmologica. 108:125-133
PURPOSE: To determine whether long-term treatment with the anti-epileptic drug vigabatrin causes damage to rabbit retina.METHODS: Five rabbits were treated continuously with a daily dose of vigabatrin solution per orally during a period of 1-8 months