Exercise Rescues Obesogenic-Related Genes in the Female Hypothalamic Arcuate Nucleus: A Potential Role of miR-211 Modulation.

Autor: Rapps K; Faculty of Life Sciences, Bar Ilan University, Ramat Gan 5290002, Israel.; Institute of Animal Science, Agricultural Research Organization, The Volcani Center, Rishon LeZion 7528809, Israel.; Gonda Multidisciplinary Brain Research Center, Bar Ilan University, Ramat Gan 5290002, Israel., Marco A; Neuro-Epigenetics Laboratory, Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 7610001, Israel., Pe'er-Nissan H; Faculty of Life Sciences, Bar Ilan University, Ramat Gan 5290002, Israel.; Gonda Multidisciplinary Brain Research Center, Bar Ilan University, Ramat Gan 5290002, Israel., Kisliouk T; Institute of Animal Science, Agricultural Research Organization, The Volcani Center, Rishon LeZion 7528809, Israel., Stemp G; Gonda Multidisciplinary Brain Research Center, Bar Ilan University, Ramat Gan 5290002, Israel., Yadid G; Faculty of Life Sciences, Bar Ilan University, Ramat Gan 5290002, Israel.; Gonda Multidisciplinary Brain Research Center, Bar Ilan University, Ramat Gan 5290002, Israel., Weller A; Gonda Multidisciplinary Brain Research Center, Bar Ilan University, Ramat Gan 5290002, Israel.; Department of Psychology, Bar Ilan University, Ramat Gan 5290002, Israel., Meiri N; Institute of Animal Science, Agricultural Research Organization, The Volcani Center, Rishon LeZion 7528809, Israel.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2024 Jun 29; Vol. 25 (13). Date of Electronic Publication: 2024 Jun 29.

Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[ d ]thiazol-5-ylamino)-6-( tert -butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases.

Autor: Haile PA; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States., Casillas LN; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States., Votta BJ; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States., Wang GZ; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States., Charnley AK; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States., Dong X; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States., Bury MJ; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States., Romano JJ; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States., Mehlmann JF; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States., King BW; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States., Erhard KF; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States., Hanning CR; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States., Lipshutz DB; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States., Desai BM; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States., Capriotti CA; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States., Schaeffer MC; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States., Berger SB; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States., Mahajan MK; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States., Reilly MA; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States., Nagilla R; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States., Rivera EJ; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States., Sun HH; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States., Kenna JK; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States., Beal AM; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States., Ouellette MT; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States., Kelly M; GlaxoSmithKline , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Stemp G; GlaxoSmithKline , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Convery MA; GlaxoSmithKline , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Vossenkämper A; Centre for Immunobiology, Blizard Institute, Barts and The London School of Medicine and Dentistry , Queen Mary University of London , London E1 2AD , U.K., MacDonald TT; Centre for Immunobiology, Blizard Institute, Barts and The London School of Medicine and Dentistry , Queen Mary University of London , London E1 2AD , U.K., Gough PJ; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States., Bertin J; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States., Marquis RW; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2019 Jul 25; Vol. 62 (14), pp. 6482-6494. Date of Electronic Publication: 2019 Jul 02.

Pharmacological characterization of extracellular acidification rate responses in human D2(long), D3 and D4.4 receptors expressed in Chinese hamster ovary cells

Autor: Coldwell, M C, Boyfield, I, Brown, A M, Stemp, G, Middlemiss, D N

This study characterized pharmacologically the functional responses to agonists at human dopamine D2(long) (hD2), D3 (hD3) and D4.4 (hD4) receptors separately expressed in cloned cells using the cytosensor microphysiometer. Dopaminergic receptor agon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::40632e9cb168d537b290d01db25ff5b3
https://europepmc.org/articles/PMC1566129/

Three-Dimensional Quantitative Structure–Activity Relationship Study of Transient Receptor Potential Vanilloid 1 Channel Antagonists Reveals Potential for Drug Design Purposes.

Autor: Gianibbi, Beatrice¹ (AUTHOR) beatrice.gianibbi@student.unisi.it, Visibelli, Anna¹ (AUTHOR) anna.visibelli2@unisi.it, Spinsanti, Giacomo^1,2 (AUTHOR) giacomo.spinsanti@unisi.it, Spiga, Ottavia^1,2,3 (AUTHOR) ottavia.spiga@unisi.it

Publikováno v: International Journal of Molecular Sciences. Jul2024, Vol. 25 Issue 14, p7951. 12p.

In vitro and in vivo cytogenetic studies of three β-lactam antibiotics (penicillin VK, ampicillin and carbenicillin).

Autor: Stemp, G., Pascoe, S., Gatehouse, D.

Publikováno v: Mutagenesis; Nov1989, Vol. 4 Issue 6, p439-445, 7p