Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Stem-cell biotechnology"'
Autor:
Tatsuki Ueda, Sara Shiina, Shoichi Iriguchi, Seitaro Terakura, Yohei Kawai, Ryotaro Kabai, Satoko Sakamoto, Akira Watanabe, Kohei Ohara, Bo Wang, Huaigeng Xu, Atsutaka Minagawa, Akitsu Hotta, Knut Woltjen, Yasushi Uemura, Yuzo Kodama, Hiroshi Seno, Tetsuya Nakatsura, Koji Tamada, Shin Kaneko
Publikováno v:
Nature Biomedical Engineering. 7:24-37
The effectiveness of chimaeric antigen receptor (CAR) T-cell immunotherapies against solid tumours relies on the accumulation, proliferation and persistency of T cells at the tumour site. Here we show that the proliferation of CD8αβ cytotoxic CAR T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feaf1d32b76eed8c9562ff35df767fb6
https://doi.org/10.1038/s41551-022-00969-0
https://doi.org/10.1038/s41551-022-00969-0
Autor:
Ramin Banan Sadeghian, Ryohei Ueno, Yuji Takata, Akihiko Kawakami, Cheng Ma, Toshikazu Araoka, Minoru Takasato, Ryuji Yokokawa
Publikováno v:
Communications Biology. 6
Of late, numerous microphysiological systems have been employed to model the renal proximal tubule. Yet there is lack of research on refining the functions of the proximal tubule epithelial layer—selective filtration and reabsorption. In this repor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7885a54eb256dd7e03d3a10ec445a7f1
http://hdl.handle.net/2433/282144
http://hdl.handle.net/2433/282144
Autor:
Fuad Gandhi Torizal, Yoshikazu Kawai, Masataka Minami, Ikki Horiguchi, Tatsuo Michiue, Yasuyuki Sakai, Qiao You Lau, Masato Ibuki, Masato Horikawa, Masaki Nishikawa
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Communications Biology
Communications Biology
Three-dimensional aggregate-suspension culture is a potential biomanufacturing method to produce a large number of human induced pluripotent stem cells (hiPSCs); however, the use of expensive growth factors and method-induced mechanical stress potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4f770fbf8fba8f7a806c22a6b551ff6
https://doaj.org/article/a9aeb1e539894f8bb934595d323399c7
https://doaj.org/article/a9aeb1e539894f8bb934595d323399c7
Autor:
Kumitaa Theva Das, Wai Hoe Ng, V. Kalidasan, Oluwaseun Ayodeji Ishola, Jun Jie Tan, Nithya Ravichantar
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Sci. Rep. 11:19265 (2021)
Scientific Reports
Sci. Rep. 11:19265 (2021)
Scientific Reports
Gene therapy revolves around modifying genetic makeup by inserting foreign nucleic acids into targeted cells via gene delivery methods to treat a particular disease. While the genes targeted play a key role in gene therapy, the gene delivery system u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb282a847a6b4536603a5e64aca6f225
https://doaj.org/article/2f0a52a5611d43b2989a84073a2f6158
https://doaj.org/article/2f0a52a5611d43b2989a84073a2f6158
Autor:
Daniel Urrutia-Cabrera, Iris Bartels, Ralf Dressel, Anna Maierhofer, Yuliia Tereshchenko, Iga Grządzielewska, Ignacio Rodriguez-Polo, Felix Mattern, Thomas Haaf, Stoyan Petkov, Sophie Mißbach, Rüdiger Behr
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Scientific Reports
Scientific Reports
Non-human primates (NHPs) are, due to their close phylogenetic relationship to humans, excellent animal models to study clinically relevant mutations. However, the toolbox for the genetic modification of NHPs is less developed than those for other sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2db60fbd6c6afade3a2d78b00eeaaf4c
https://doaj.org/article/a91a5aa2c75a42bd99754c8131f457a6
https://doaj.org/article/a91a5aa2c75a42bd99754c8131f457a6
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports
Scientific Reports
Mesenchymal stromal/stem cells (MSCs) are currently being used in clinical trials as proposed treatments for a large range of genetic, immunological, orthopaedic, cardiovascular, endocrine and neurological disorders. MSCs are potent anti-inflammatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dc310e409518b5699dd351d6e579871
https://doaj.org/article/e5a54ba5e62144d4baeb75b79d590f27
https://doaj.org/article/e5a54ba5e62144d4baeb75b79d590f27
Publikováno v:
npj Regenerative Medicine, Vol 6, Iss 1, Pp 1-17 (2021)
NPJ Regen Med
NPJ Regenerative Medicine
NPJ Regen Med
NPJ Regenerative Medicine
The adult heart is a vital and highly specialized organ of the human body, with limited capability of self-repair and regeneration in case of injury or disease. Engineering biomimetic cardiac tissue to regenerate the heart has been an ambition in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ae0955fac9ef8cd398545c58d78c80e
https://doaj.org/article/82e44137bf2a4c13a2a796924cd5f438
https://doaj.org/article/82e44137bf2a4c13a2a796924cd5f438
Autor:
Samatha Bhat, S. Jyothi Prasanna, Raviraja N. Seetharam, Pachaiyappan Viswanathan, Shashank Chandanala
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Scientific Reports
Scientific Reports
Bone marrow-derived mesenchymal stromal cells (BM-MSCs) are gaining increasing importance in the field of regenerative medicine. Although therapeutic value of MSCs is now being established through many clinical trials, issues have been raised regardi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16b86ce37988150dc4b443b025aed242
https://doaj.org/article/507e5f051ff34c1ba30abd9f3c42903b
https://doaj.org/article/507e5f051ff34c1ba30abd9f3c42903b
Autor:
Kevin P. White, Savaş Tay, Isabel Romero-Calvo, Brooke Schuster, Jonathan Matthews, Sara Saheb Kashaf, Kori Kirby, Michael Junkin, Christopher R. Weber, Andrey Rzhetsky
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications
Three-dimensional (3D) cell culture technologies, such as organoids, are physiologically relevant models for basic and clinical applications. Automated microfluidics offers advantages in high-throughput and precision analysis of cells but is not yet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a504de37ee98c8121b89398cf26f393e
http://link.springer.com/article/10.1038/s41467-020-19058-4
http://link.springer.com/article/10.1038/s41467-020-19058-4
Autor:
Satomi Noguchi, Kei Yamamoto, Yumi Soejima, Shinichi Suzuki, Seiichi Takenoshita, Izumi Nakamura, Mizuki Goto, Ken Ishioka, Noriko Ohtsuki, Takumi Era, Yokouchi Yuji, Satoru Suzuki
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Many human diseases ranging from cancer to hereditary disorders are caused by single-nucleotide mutations in critical genes. Repairing these mutations would significantly improve the quality of life for patients with hereditary diseases. However, cur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b99bc747ba9d50fda260d44d44be2c6f
http://link.springer.com/article/10.1038/s41598-020-70401-7
http://link.springer.com/article/10.1038/s41598-020-70401-7