Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Stem cell fate determination"'
Autor:
Rongzhi Lin, Hui Han, Shuibin Lin, Jieyi Ma, Xiaochen Wang, Maosheng Cheng, Fengyin Liang, Yi-Zhou Jiang, Qiuchan Xiong, Lu Wang, Quan Yuan, Yu Liang, Zhong Pei, Peng Yu, Ganping Wang, Demeng Chen
Publikováno v:
Genes and Diseases, Vol 9, Iss 1, Pp 268-274 (2022)
Genes & Diseases
Genes & Diseases
Ribosome RNA (rRNA) accounts for more than 80% of the cell's total RNA, while the physiological functions of rRNA modifications are poorly understood. Mutations of 18S rRNA m6A methyltransferase METTL5 cause intellectual disability, microcephaly, and
Publikováno v:
ACS Chemical Neuroscience. 12:441-446
Members of the lysine-specific histone demethylase 5 (KDM5/JARID1) family are known to play important roles in stem cell fate determination. Here, using the KDM5 inhibitor C70 (KDM5-C70), we demonstrated that the histone demethylase activity of the K
Publikováno v:
Current Stem Cell Reports. 7:30-38
This review summarizes the current insights into stem cell fate determination by biomechanics. We also highlight recent findings that illustrate how mechanotransduction conveys changes in the extrinsic environment to program stem cell fate and how th
Autor:
Alif Meem Nurani, Yuki Kondo, Tomoyuki Furuya, Takashi Ueda, Sachihiro Matsunaga, Yuki Sakamoto, Kazuo Ebine, Hiroo Fukuda, Yasuko Ozawa
Publikováno v:
Plant and Cell Physiology. 61:255-264
Stem cells undergo cell division and differentiation to ensure organized tissue development. Because plant cells are immobile, plant stem cells ought to decide their cell fate prior to differentiation, to locate specialized cells in the correct posit
Autor:
Thomas Bock, Niklas Iffländer, Chiara Rolando, Elli-Anna Balta, Tanzila Mukhtar, Verdon Taylor, Pascal Forcella
SummaryDuring brain homeostasis, stem cell fate determination is crucial to guarantee function, adaptation and regeneration while preventing neurodegeneration and cognitive impairment. How neural stem cells (NSCs) are instructed to generate neurons o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bcfb5e64c173249201cfd806b73de821
https://doi.org/10.1101/2021.10.22.465432
https://doi.org/10.1101/2021.10.22.465432
Autor:
Paul H. Krebsbach, Cheri X. Deng, Byoung Choul Kim, Tuğba Topal, Shuichi Takayama, Luis G. Villa-Diaz
Publikováno v:
Integrative biology : quantitative biosciences from nano to macro, vol 11, iss 2
Human embryonic stem cells subjected to a one-time uniaxial stretch for as short as 30-min on a flexible substrate coated with Matrigel experienced rapid and irreversible nuclear-to-cytoplasmic translocation of NANOG and OCT4, but not Sox2. Transloca
Autor:
Misato Iwashita, Yoichi Kosodo, Min-Young Cho, Takahiro Fujisawa, Makoto Ikeya, Satoru Kidoaki, Hatsumi Ohta
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-17 (2019)
Scientific Reports
Scientific Reports
The mechanical properties of the extracellular microenvironment, including its stiffness, play a crucial role in stem cell fate determination. Although previous studies have demonstrated that the developing brain exhibits spatiotemporal diversity in
Publikováno v:
Cell Biology and Toxicology
Similar to epigenetic DNA and histone modifications, epitranscriptomic modifications (RNA modifications) have emerged as crucial regulators in temporal and spatial gene expression during eukaryotic development. To date, over 170 diverse types of chem
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-13 (2021)
Background Dental pulp stem cells (DPSCs) are a promising cell source in endodontic regeneration and tissue engineering with limited self-renewal and pluripotency capacity. N6-methyladenosine (m6A) is the most prevalent, reversible internal modificat
Autor:
Gabriela Krivdova, Florin Schneiter, Jocelyn Chen, Sabrina A. Smith, Jessica McLeod, John E. Dick, Andy G.X. Zeng, Veronique Voisin, M. C. Shoong, Stephanie Z. Xie, Michelle Chan-Seng-Yue, Kerstin B. Kaufmann, D. Parris, S.-I. Takayanagi, Laura García-Prat, Timm Schroeder, K. Pan, Olga I. Gan, Alex Murison, Mathieu Lupien, Elvin Wagenblast, W. Wang, K. Gupta
SummaryIt is critical to understand how quiescent long-term hematopoietic stem cells (LT-HSC) sense demand from daily and stress-mediated cues and transition into bioenergetically active progeny to differentiate and meet these cellular needs. Here, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::759f2155621265901831dd9d12777bff
https://doi.org/10.1101/2021.02.24.432720
https://doi.org/10.1101/2021.02.24.432720