Zobrazeno 1 - 10 of 55 pro vyhledávání: '"Stem Cells/drug effects"'
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Attenuation of the pro-inflammatory signature of lung cancer-derived mesenchymal stromal cells by statins
Autor: Ivan Stamenkovic, Giulia Fregni, Sabine Galland, Patricia Martin, Igor Letovanec
Publikováno v: Cancer letters, vol. 484, pp. 50-64
Solid tumor growth triggers a dynamic host response, which recapitulates wound healing and defines the tumor microenvironment (TME). In addition to the action of the tumor cells themselves, the TME is maintained by a myriad of immune and stromal cell
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46d4c526f18540dbdc86599d3242ed3f
https://doi.org/10.1016/j.canlet.2020.05.005
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3
The application of omics-based human liver platforms for investigating the mechanism of drug-induced hepatotoxicity in vitro
Autor: Theo M. de Kok, Gökhan Ertaylan, Charlie D Pieterman, Jian Jiang, Ralf Peeters
Publikováno v: Archives of Toxicology. 93:3067-3098
Drug-induced liver injury (DILI) complicates safety assessment for new drugs and poses major threats to both patient health and drug development in the pharmaceutical industry. A number of human liver cell-based in vitro models combined with toxicoge
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4f2bbf8ee49c1491affb3577c1e40f5
https://doi.org/10.1007/s00204-019-02585-5
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4
5-FU promotes stemness of colorectal cancer via p53-mediated WNT/β-catenin pathway activation
Autor: Kang Yell Choi, Jong Chan Park, Jeong Su Yoon, Yong Hee Cho, Dong Woo Kang, Eun Ji Ro, Hans Clevers, Tae Il Kim, Tomohiro Mizutani
Publikováno v: Nature Communications, 11(1). Nature Publishing Group
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
5-Fluorouracil (5-FU) remains the first-line treatment for colorectal cancer (CRC). Although 5-FU initially de-bulks the tumor mass, recurrence after chemotherapy is the barrier to effective clinical outcomes for CRC patients. Here, we demonstrate th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5c3cd05c8716e3e7fd22f0717726d0f
https://hdl.handle.net/20.500.11755/de483e27-9a68-49de-bf37-80bb92ac9c00
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5
Clonal heterogeneity of acute myeloid leukemia treated with the IDH2 inhibitor enasidenib
Autor: George S. Vassiliou, Eytan M. Stein, Cyril Quivoron, Ross L. Levine, Lynn Quek, Stéphane de Botton, Paresh Vyas, Bilyana Stoilova, Michael Amatangelo, Alison Kennedy, M. S. Vijayabaskar, Alan Shih, O. Bernard, Virginie Penard-Lacronique, Katharine E. Yen, Véronique Saada, Maël Heiblig, Samar Alsafadi, Marlen Metzner, Kyle J. MacBeth, Muriel D. David, Andy Peniket, Anjan Thakurta, Sam Agresta, Christophe Willekens
Publikováno v: Quek, L, David, M D, Kennedy, A, Metzner, M, Amatangelo, M, Shih, A, Stoilova, B, Quivoron, C, Heiblig, M, Willekens, C, Saada, V, Alsafadi, S, Vijayabaskar, M S, Peniket, A, Bernard, O A, Agresta, S, Yen, K, MacBeth, K, Stein, E, Vassiliou, G S, Levine, R, De Botton, S, Thakurta, A, Penard-Lacronique, V & Vyas, P 2018, ' Clonal heterogeneity of acute myeloid leukemia treated with the IDH2 inhibitor enasidenib ', Nature Medicine, vol. 24, no. 8, pp. 1167-1177 . https://doi.org/10.1038/s41591-018-0115-6
Mutations in the gene encoding isocitrate dehydrogenase 2 (IDH2) occur in several types of cancer, including acute myeloid leukemia (AML). In model systems, mutant IDH2 causes hematopoietic differentiation arrest. Enasidenib, a selective small-molecu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d30ad4500bdf6ee72adaf9de1577627
https://doi.org/10.1038/s41591-018-0115-6
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6
Squaramide-based supramolecular materials for three-dimensional cell culture of human induced pluripotent stem cells and their derivatives
Autor: Thomas H. Sharp, Tingxian Liu, Marco M. R. M. Hendrix, Willem E. M. Noteborn, Ciqing Tong, Roxanne E. Kieltyka, Victorio Saez Talens, Ilja K. Voets, Christine L. Mummery, Valeria V. Orlova
Publikováno v: Biomacromolecules, 19(4), 1091-1099. American Chemical Society
Biomacromolecules
Synthetic hydrogel materials can recapitulate the natural cell microenvironment; however, it is equally necessary that the gels maintain cell viability and phenotype while permitting reisolation without stress, especially for use in the stem cell fie
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a64d6c6fbb79e74fb8d49cbdeb2358dc
https://doi.org/10.1021/acs.biomac.7b01614
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7
Modified mRNA for BMP-2 in Combination with Biomaterials Serves as a Transcript-Activated Matrix for Effectively Inducing Osteogenic Pathways in Stem Cells
Autor: Christian Koch, Christian Plank, Carsten Rudolph, Elizabeth R. Balmayor, Martijn van Griensven, Johannes Geiger, Manish K. Aneja
Publikováno v: Stem Cells and Development, 26(1), 25-34. Mary Ann Liebert Inc.
Bone regeneration using stem cells and growth factors has disadvantages while needing to use supraphysiological growth factors concentrations. Gene therapy has been proposed as alternative, but also has limitation. Messenger RNA (mRNA)-based transcri
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b99fee874a31717442ee1a3d0d1cb9
https://doi.org/10.1089/scd.2016.0171
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9
The biological response of mesenchymal stromal cells to thymol and carvacrol in comparison to their essential oil: An innovative new study
Autor: Khalid Sadki, Mustapha Najimi, Philippe Lewalle, Mehdi Najar, Makram Merimi, Fatima Bouhtit, Laurence Lagneaux, Douâa Moussa Agha, Rahma Melki, Abdellah Hamal
Publikováno v: Food and chemical toxicology, 134
Food and chemical toxicology, Vol. 134, p. 110844 [1-8] (2019)
Mesenchymal stromal cells (MSCs) represent a progenitor cell population with several biological properties. MSCs are thus of therapeutic interest for cell-based therapy but great efforts are needed to enhance their efficiency and safety. Herbal remed
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37da97b067f1e652e40573cb74f782fa
https://pubmed.ncbi.nlm.nih.gov/31562950
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10
Mechanisms of cisplatin resistance and targeting of cancer stem cells: Adding glycosylation to the equation
Autor: Manuel Neves, Lúcio Lara Santos, Cristiana Gaiteiro, Yehuda G. Assaraf, Andreia F. Peixoto, Celso A. Reis, José Alexandre Ferreira
Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Cisplatin-based chemotherapeutic regimens are the most frequently used (neo)adjuvant treatments for the majority of solid tumors. While platinum-based chemotherapeutic regimens have proven effective against highly proliferative malignant tumors, sign
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3600de9f18dcc7056953d171d9bc55da
https://doi.org/10.1016/j.drup.2015.11.003
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